Our Science – Palayoor Website

Sanjeewani T. Palayoor, Ph.D.

Radiation Oncology Branch Experimental Therapeutics Section Staff Scientist Bldg 10/ Rm 3B49 9000 Rockville Pike Bethesda, MD 20892 Phone:   301 496 1401 Fax:   301 480 1434 E-Mail:   palayoor@mail.nih.gov

Biography

Dr. Palayoor received her education in India and worked at the Tata Memorial Hospital, Bombay before coming to the US. She did her postdoctoral research at the Yale Medical School, New Haven, CT and Dana Farber Cancer Institute, Boston, MA. She joined NIH in 1999.

Research

Primary research objective is to identify and develop novel approaches to enhance the radiosensitivity of tumors.

- Nonsteroidal anti-inflammatory drugs (NSAIDs) as radiosensitizers.

- Cellular targets of NSAIDs pertinent in radiosensitization. COX-2 dependent and COX-2 independent targets.

- Gene expression analysis of tumor and normal cells treated with traditional NSAID ibuprofen, COX-2-specific inhibitors NS398 and celecoxib and COX-2 RNAi.

- Hypoxia, Hypoxia-inducible factor (HIF) and radiosensitivity.

- HIF inhibitors as radiosensitizers.

- Gene expression analysis of prostate carcinoma cells treated with single and fractionated dose irradiation. Identify radiation-induced targets and to evaluate their potential for using radiation to prime cells for molecular targeted drug therapy.

This page was last updated on 7/15/2008.