Summaries & Associations of Study Results
TR-500 Naphthalene
Target Organs and Levels of Evidence
NTP Technical Report Number 500
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| NAPHTHALENE 91-20-3 |
05/18/00 | CHEMICAL INTERMEDIATE, INSECTICIDES, REPELLANTS, ANTISEPTIC, VERMICIDE, SYNTHETIC RESINS; IN VARIOUS COMMERCICAL MOTH REPELLANTS AND TOILET BOWL CLEANERS; TOPICALLY IN VETERINARY MEDICINE. PREPARED FROM COAL TAR. | Inhalation R: 0, 10, 30, OR 60 PPM; 58/SEX/GROUP | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | NASAL CAVITY: (RESPIRATORY EPITHELIUM) ADENOMA 0/49 6/49 8/48 15/48 (OLFACTORY EPITHELIUM) NEUROBLASTOMA 0/49 0/49 4/48 3/48 | |||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: (OLFACTORY EPITHELIUM) ATYPICAL HYPERPLASIA; ATROPHY; CHRONIC INFLAMMATION; HYALINE DEGENERATION; (RESPIRATORY EPITHELIUM) HYPERPLASIA; SQUAMOUS METAPLASIA; HYALINE DEGENERATION; GOBLET CELL HYPERPLASIA; (GLANDS) HYPERPLASIA; SQUAMOUS METAPLASIA | |||
| FR: CLEAR EVIDENCE | NASAL CAVITY: (RESPIRATORY EPITHELIUM) ADENOMA 0/49 0/49 4/49 2/49 (OLFACTORY EPITHELIUM) NEUROBLASTOMA 0/49 2/49 3/49 12/49 | |||
| NON-NEOPLASTIC LESIONS: | NASAL CAVITY: (OLFACTORY EPITHELIUM) ATYPICAL HYPERPLASIA; ATROPHY; CHRONIC INFLAMMATION; HYALINE DEGENERATION; (RESPIRATORY EPITHELIUM) HYPERPLASIA; SQUAMOUS METAPLASIA; HYALINE DEGENERATION; GOBLET CELL HYPERPLASIA; (GLANDS) HYPERPLASIA; SQUAMOUS METAPLASIA | |||
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