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Kristine Witt, M.Sc.

Toxicology Branch

Kristine Witt, M.Sc.
Kristine Witt, M.Sc.

Tel (919) 541-2761
Fax (919) 316-4511
P.O. Box 12233
Mail Drop EC-34
Research Triangle Park, North Carolina 27709
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Kristine Witt, M.Sc., is a toxicologist in the Toxicology Branch of the National Toxicology Program. Witt manages the genetic toxicology testing contracts of the National Toxicology Program (NTP) and provides genetic toxicology test data review and evaluation for inclusion in the NTP Technical Reports. She is also involved in assay selection and study design for the NTP’s High Throughput Screening initiative, and she assists the NTP’s Center for the Evaluation of Risks for Human Reproduction by providing background information on exposures that carry potential reproductive risks.

In addition to her work for the NTP, Witt is a clinical investigator who manages NIEHS research studies on cytogenetic endpoints in study populations exposed to medications with known or suspected genetic toxicity, with an emphasis on exposure risks to children.  She has an extensive background both in clinical cytogenetics and genetic toxicology, and has presented numerous presentations at national meetings and workshops. Witt received a B.Sc. in zoology from Ohio State University and an M.Sc. in genetics from Ohio State University.

Selected Publications

  1. Livingston GL, Lockey J, Witt KL, Rogers S.   (1985)  An unstable giant satellite associated with chromosomes 21 and 22 in the same individual.  American J. Human Genetics 37: 553-560.
  2. Rutledge JC, Cain KT, Kyle J, Cornett CV, Cacheiro NLA, Witt K, Shelby MD, Generoso WM.  (1990)   Increased incidence of developmental anomalies among descendants of carriers of methylene(bis)acrylamide-induced balanced reciprocal translocations.  Mutation Res. 229: 161-172.
  3. Bishop JB, Witt KL, Gulati D, MacGregor J.  (1990) The mutagenicity of the anti-inflammatory drug salicylazosulfapyridine (SASP).  Mutagenesis 5: 549-554.
  4. Livingston GK, Witt KL, Gandhi OP, Chatterjee I, Roti Roti JL. (1991) The reproductive integrity of mammalian cells exposed to power frequency electromagnetic fields.  Environ. Mol. Mutagen. 17: 49-59.
  5. Witt KL, Gudi R, Bishop JB.  (1992) Induction of kinetochore positive and negative micronuclei in mouse bone marrow cells by salicylazosulfapyridine and sulfapyridine.  Mutation Res. Letters 283:  53-57.
  6. Witt KL,  Gulati DK, Kaur P, Shelby MD. (1995) Phenolphthalein:  induction of micronucleated erythrocytes in mice.   Mutation Res. 341:  151-160.   
  7. Generoso WM, Witt KL, Cain KT, Hughes L, Lockhart A-M C, Shelby MD.  (1995)  Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice.  Mutation Res. 345: 167-180.
  8. Witt KL, Bishop JB.  (1996) Mutagenicity of anticancer drugs in mammalian germ cells.   Mutation Res. 355 : 209-234.
  9. Bishop JB, Witt KL, Sloane RA.  (1997)  Genetic toxicities of human teratogens.  Mutation Res. 396: 9-43.
  10. Witt KL, Knapton A, Wehr CM, Hook GJ, Mirsalis J, Shelby MD, MacGregor JT. (2000) Micronucleated erythrocyte frequency in peripheral blood of B6C3F1 mice from short-term, prechronic and chronic studies of the NTP carcinogenesis bioassay program. Environ. Mol. Mutagen. 36 (3): 163-194.
  11. Robbins WA, Witt KL, Haseman J, Dunson D, Troiani L, Cohen M, Hamilton CD, Darney SP, Beyler S, Raburn D, Tedder S, Shelby MD, Bishop JB.  (2001)  Effects of antiretroviral therapy on genetic and morphological endpoints in lymphocytes and sperm of people with HIV infection. J Infect Dis., Jul 15;184(2):127-35.
  12. Ress NB, Witt KL, Xu J, Haseman JK, Bucher JR. (2002)  Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline:  implications for diazoaminobenzene carcinogenicity. Mutation Res. 521: 201 - 208.
  13. Witt KL, Hughes L, Burka LT, McFee A, Bishop JB.  (2003)  Mouse bone marrow micronucleus test results do not predict the germ cell mutagenicity of N-hydroxy-methylacrylamide in the mouse dominant lethal assay. Environ. Mol. Mutagen.41:  111-120.
  14. Bishop JB, Witt KL, Tice RR, Wolfe G. (2004) Genetic damage detected in CD-1 mouse pups exposed perinatally to 3’-azido-3’-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage.  Environ Molec Mutagen. 43:3-9.
  15. Bishop JB, Tani Y, Witt KL, Johnson JA, Peddada S, Dunnick JK, Nyska A.  (2004) Mitochondrial damage revealed by morphometric and semiquantitative analysis of mouse pup cardiomyocytes following in utero and postnatal exposure to zidovudine and lamivudine. Toxicological Sciences: 512-517.
  16. Witt KL, Tice RR, Wolfe G, Bishop JB.  (2004) Genetic damage detected in CD-1 mouse pups exposed perinatally to 3’-azido-3’-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage. II:  Effects of the individual agents compared to combination treatment. Environ Mol Mutagen 44:  321-328.
  17. Ghanayem BI, Witt KL, El-Hadri L, Hoffler U, Kissling G, Shelby MD, Bishop JB. (2005) Comparison of germ cell mutagenicity in male CYP 2E1-null and wild-type mice treated with acrylamide:  evidence supporting a glycidamide-mediated effect.  Biol Reproduction 72: 157-163.
  18. Ghanayem BI, Witt KL, Kissling GE, Tice RR, Recio L.  (2005) Absence of acrylamide-induced genotoxicity in CYP2E1-null mice:  evidence consistent with a glycidamide-mediated effect.  Mutat Res 578: 284-297. 
  19. Wyrobek AJ, Mulvihill JJ, Wassom JS, Malling HV, Shelby MD, Lewis SE, Witt KL, Preston RJ, Perreault SD, Allen JW, DeMarini DM, Woychik RP, Bishop JB, Workshop Presenters. (2007) Assessing human germ-cell mutagenesis in the Postgenome Era: A celebration of the legacy of William Lawson (Bill) Russell.  Environ Mol Mutagen 48: 71-95.
  20. Chan SSL, Santos JH, Meyer JN, Mandavilli BS, Cook DL Jr., McCash CL, Kissling GE, Nyska A, Foley JF, van Houten B, Copeland WC, Walker VE, Witt KL, Bishop JB. (2007) Mitochondrial toxicity in cardiomyocytes of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.  Invited paper, special issue of Environ Mol Mutagen 48: 190-200.
  21. Witt KL,Cunningham CK, Patterson KB, Kissling GE, Dertinger SD, Livingston E, Bishop JB. (2007) Elevated frequencies of micronucleated erythrocytes in
    infants exposed to zidovudine In utero and postpartum to prevent mother-to-child transmission of HIV. Environ Molec Mutagen 48: 322-329.
  22. Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutation research 2008 649(1-2):101-113. [Abstract] ( Exit NIEHS

Book chapter

  1. Bishop JB, Witt KL. (1995)  In vivo germ cell mutagenesis assays, in:  Environmental Mutagenesis (eds. , Phillips, D.H., and Venitt, S.), Bios Scientific Publishers, Ltd., Oxford, UK., pp. 155-179.

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