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Your search term(s) "Diagnostic Tests" returned 58 results.
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Clinical Malignant Hematology. Columbus, OH: McGraw Hill. 2007. 1201 p.
This comprehensive reference book covers the full spectrum of cancers in the blood, bone marrow, and lymphatic system, including leukemia, lymphoma, and myeloma. The textbook includes 109 chapters in 15 sections: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, chronic lymphocytic leukemia, hairy cell leukemia, special topics in leukemia, myelodysplastic syndromes, chronic myeloproliferative diseases, non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, special topics in lymphoma, multiple myeloma, special topics in multiple myeloma, stem cell transplantation, and special topics in neoplastic hematology. Each chapter details the workup, staging, epidemiology, risk factors, pathology, symptoms, diagnosis, differential diagnosis, and treatment of hematologic malignancies. The chapters include full coverage of all treatment options such as chemotherapy, monoclonal antibodies, and hematopoietic stem cell transplantation. The text includes background chapters that offer guidance on how to address treatment complications and other supportive care issues. The textbook is illustrated with black-and-white clinical pictures and photomicrographs displaying examples of peripheral blood smears and bone marrow aspirates; one section of full-color plates is included. A detailed subject index concludes the volume.
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Diagnosis. Montreal, QC: Canadian Hemophilia Society. 2007. pp 23-28.
This chapter on diagnosis is from a patient education monograph from the Canadian Hemophilia Society that provides comprehensive information about von Willebrand disease (VWD). This disease is characterized by problems in the von Willebrand factor (VWF), a protein in the blood that is necessary for proper blood coagulation. When there is not enough VWF in the blood, or when it does not work the way it should, the blood takes longer to clot. Written in a question-and-answer format, this chapter considers the difficulty of diagnosing VWD, noting that VWD is often misdiagnosed. Readers are encouraged to visit a hematologist for any concerns about a potential bleeding disorder. The author emphasizes that routine blood tests will often show normal results even in people with VWD, so specialized blood tests are needed. Tests mentioned include bleeding time, factor VIII:C, VWF antigen, ristocetin cofactor activity, VWF multimers, and platelet function tests. The final section of the chapter considers the emotions and adjustment that people may experience after being diagnosed with VWF. 1 table.
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Genetic Basis of Myeloproliferative Disorders. IN Hematology 2007. Washington, DC: American Society of Hematology. 2007. pp 1-10.
This chapter, from Hematology 2007, reviews the genetic basis of myeloproliferative disorders (MPD). The author provides a brief history of the understanding of MPD, beginning with the conceptual work of William Dameshek in 1951 that provided the basis for understanding MPD as a continuum of related syndromes, possibly with a common pathogenetic cause. Recognition of the clonal origin of peripheral blood cells in MPD in 1976 and the ability to grow erythroid colonies in vitro in the absence of added growth factors in 1974 initiated the search for genetic alterations that might be responsible for myeloproliferation. The discovery of activating mutations in the Janus kinase 2 (JAK2) in most patients with MPD has fully transformed and energized the MPD field. The author reports on diagnostic tests for MPD, including sensitive assays for detecting the JAK2-V617F mutation. In fact, JAK2 now constitutes a prime target for developing specific inhibitors for the treatment of patients with MPD. The author concludes with a discussion of some of the unsolved questions in this area, including how a single JAK2 mutation causes three different MPD phenotypes, what other genes might be involved in the pathogenesis, and what are the factors determining the progression of MPD to acute leukemia in some patients. 2 tables. 134 references.
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Haemophilia A and Haemophilia B. IN: Roberts H.R., ed. Haemophilia and Haemostasis: A Case-Based Approach to Management. Williston, VT: Blackwell Publishing Inc. 2007. pp 3-92 .
This chapter about hemophilia A and hemophilia B is from a book that compiles a breadth of questions relating to perplexing or complicated management questions in the fields of hemophilia and hemostasis. The contributing authors have provided practical, hands-on answers to the questions sent in by practitioners in the field. This section discusses hemophilia and immune tolerance therapy, the hemophilic ankle and knee, combined hemophilia A and B carriers, hemophilia with HIV and hepatitis C, a premature infant with hemophilia, pregnancy in women with hemophilia, mild hemophilia in women, anticoagulation and hemophilia, hemophilia and scuba diving, and treatment of hemophilia and specific conditions, including hepatitis C, physical therapy, renal bleeds, ventricular septal defect repair, hepatitis C and recurrent bleeding, isotretinoin use, laser eye surgery, pseudotumors, and continuous infusion. A final section considers complications of treatment for hemophilia A and hemophilia B. Much of the information is presented through case studies. 11 figures. 55 references.
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Haemophilia and Haemostasis: A Case-Based Approach to Management. Williston, VT: Blackwell Publishing Inc. 2007. 229 p.
This book compiles a breadth of questions relating to perplexing or complicated management questions in the fields of hemophilia and hemostasis. The contributing authors have provided practical, hands-on answers to the questions sent in by practitioners in the field. The book is organized into seven sections: hemophilia A and hemophilia B, Von Willebrand disease, factor deficiencies, rare platelet and coagulation disorders, acquired bleeding diatheses, miscellaneous questions, and thrombotic disorders. Specific topics covered include the hemophilic ankle and knee, hemophilia with HIV, pregnancy in women with hemophilia, hemophilia and scuba diving, hemodialysis, hepatitis in people with hemophilia, VWD and pregnancy, Factor VIII deficiency, Factor X deficiency, Gardner-Diamond syndrome, cocaine and DDAVP, selective serotonin reuptake inhibitors (SSRIs) and clotting disturbances, the work-up for children with intracranial bleeding, treatment of antithrombin deficiency, recurrent thrombosis, and thromboembolic disease. Most sections include references, and a detailed subject index concludes the volume.
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Hairy Cell Leukemia. IN: Sekeres, M.; Kalaycio, M.; Bolwell, B., eds. Clinical Malignant Hematology. Columbus, OH: McGraw Hill. 2007. pp 265-310.
This section on hairy cell leukemia (HCL) is from a comprehensive reference book that covers the full spectrum of cancers in the blood, bone marrow, and lymphatic system, including leukemia, lymphoma, and myeloma. The authors note that HCL is a rare chronic lymphoproliferative disorder, characterized by circulating beta lymphocytes displaying prominent cytoplasmic projections and infiltrating the bone marrow and the spleen. This section offers six chapters: epidemiology, risk factors, and classification; molecular biology, pathology, and cytogenetics in HCL; clinical features and making the diagnosis; the indications for treatment and the recommended initial treatment approach for HCL; definition of remission, prognosis, and follow-up in patients with HCL; and treatment of relapsed or refractory hairy cell leukemia and new frontiers in HCL therapy. The chapters include full coverage of all treatment options such as chemotherapy, monoclonal antibodies, and hematopoietic stem cell transplantation. The chapters are illustrated with black-and-white clinical pictures and photomicrographs. Each chapter concludes with an extensive list of references.
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ITP and Pregnancy: Frequently Asked Questions. Potomac, MD: Platelet Disorder Support Association. 2007. 8 p.
Thrombocytopenia is defined as a low platelet count in the blood, with levels below 150,000 platelets per microliter (ppm) of blood, compared with a normal platelet count between 150,000 and 400,000 ppm. This booklet provides information about thrombocytopenia and pregnancy. The booklet focuses on immune thrombocytopenic purpura (ITP), an autoimmune disease, and its impact on pregnancy. Written in a question-and-answer format, the booklet reviews the condition, the differences between acute and chronic forms of ITP, the physiology and role of platelets, normal platelet counts, issues for women diagnosed with ITP before they conceived, issues for women whose thrombocytopenia was discovered during pregnancy, the recommended patient care team, symptoms, underlying disease, diagnostic tests that may be used to confirm ITP, treatment options known to be safe during pregnancy, treatment options to be avoided during pregnancy, recommended platelet counts to maintain during pregnancy, the side effects of treatments, childbirth, neonatal thrombocytopenia, breastfeeding, and where to meet other mothers with ITP and get more information. The treatments discussed include prednisone, intravenous gamma globulin (IVIG), and anti-Rho(D) immune globulin. The booklet concludes with a brief description of the Platelet Disorder Support Association; readers are encouraged to join the organization and to consult its website at www.pdsa.org. 8 references.
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ITP in Adults: Frequently Asked Questions. Potomac, MD: Platelet Disorder Support Association. 2007. 6 p.
Immune thrombocytopenic purpura (ITP) is a bleeding disorder caused when the body’s immune system destroys healthy blood platelets, misunderstanding them for disease-causing agents. This booklet provides information for adults newly diagnosed with ITP. Written in a question-and-answer format, the booklet reviews the condition; the differences between acute and chronic forms of ITP; the physiology and role of platelets; normal platelet counts; the causes of ITP, symptoms; underlying disease; diagnostic tests that may be used to confirm ITP; treatment options; the side effects of treatments; alternative treatment strategies; the incidence of depression, fatigue, and mood problems in people with ITP; pregnancy and childbirth in women with ITP; coping with curious friends and family; and where to meet other people with ITP and get more information. The treatments discussed include prednisone, intravenous gamma globulin (IVIG), and anti-Rho(D) immune globulin. The booklet explains the possible side effects of each and concludes with a brief description of the Platelet Disorder Support Association. Readers are encouraged to join the organization and to consult its website at www.pdsa.org.
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ITP in Children: Frequently Asked Questions. Potomac, MD: Platelet Disorder Support Association. 2007. 6 p.
Immune thrombocytopenic purpura (ITP) is a bleeding disorder caused when the body’s immune system destroys healthy blood platelets, mistaking them for disease-causing agents. This booklet provides information for parents of children newly diagnosed with ITP. Written in a question-and-answer format, the booklet reviews the condition; the differences between acute and chronic forms of ITP; the physiology and role of platelets; normal platelet counts; the causes of ITP; symptoms; underlying disease; diagnostic tests that may be used to confirm ITP; treatment options; the side effects of treatments; the incidence of depression, fatigue, and mood problems in people on medications for ITP; the likelihood of ITP in other members of the family; participating in sports and other activities; menstruation in young women with ITP; coping with curious friends and teachers; and where to meet other families coping with ITP and get more information. The treatments discussed include prednisone, intravenous gamma globulin (IVIG), and anti-Rho(D) immune globulin. For each treatment, the booklet explains the possible side effects. The booklet concludes with a brief description of the Platelet Disorder Support Association; parents are encouraged to join the organization and to consult its website at www.pdsa.org.
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Macrocytic Anaemias. IN: Provan, D., ed. ABC of Clinical Haematology. Williston, VT: Blackwell Publishing Inc. 2007. pp. 6-10.
Macrocytosis is a rise in the mean cell volume (MCV) of red blood cells above the normal range and may be associated with a megaloblastic or normoblastic bone marrow. This chapter about macrocytic anemias is from a book on clinical hematology, written by specialists for nonspecialists. The book is designed to be easy to use and covers the symptoms, investigations, treatment, and management of conditions presenting in day-to-day practice. In this chapter, the authors review megaloblastic bone marrow, vitamin B12 or folate deficiency, neural tube defects, other causes of macrocytosis, diagnostic tests used to confirm macrocytic anemia, and treatment. The chapter is illustrated with full-color photographs, drawings, and charts. 6 figures. 1 table. 10 references.
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