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| Topic: |
hematologic diseases (he) |
| Title: |
Bleeding And Thrombosis Risks in Plasma Cell Dyscrasias. |
| Author: |
Eby, C.S. |
| Source: |
IN: Hematology 2007. Washington, DC: American Society of Hematology. 2007. pp.158-164. |
| Availability: |
Available from American Society of Hematology. 1900 M Street NW, Suite 200, Washington, DC 20036. Email: ASH@hematology.org. Website: www.asheducationbook.org. Price: Available free on website. |
| Abstract: |
This chapter, from the annual Hematology 2007, considers the bleeding and thrombosis, or clotting, risks in patients with plasma cell dyscrasias, including multiple myeloma, Waldenstrom macroglobulinemia, and other B cell malignancies. The author notes that overt bleeding is relatively uncommon in these patients, despite frequent abnormal screening hemostasis tests. However, acquired von Willebrand deficiency and light-chain (AL) amyloidosis, and amyloidosis complicating multiple myeloma can present with serious hemorrhagic complications that are challenging to manage. The author notes that present understanding is incomplete regarding the complex interactions among malignant plasma cells, inflammatory and hemostasis pathways, and treatment modalities that combine to produce thrombotic complications. The author concludes by calling for additional research to assist clinicians in providing venous thromboembolism (VTE) prophylaxis to patients with plasma cell dyscrasias. 1 figure. 4 tables. 67 references. |
| Format: |
Book Chapter |
| Language: |
English. |
| Major Keywords: |
Hematologic Diseases. Thrombosis. Hemorrhage. Coagulation. Cancer. Patient Care Management. Risk Factors. |
| Minor Keywords: |
Multiple Myeloma. Amyloidosis. Chemotherapy. Drug Effects. Patient Selection. Complications. Hemostasis. Von Willebrand Disease. Prevention. |
| Publication Number: |
HEBK10218 |
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