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| Topic: |
hematologic diseases (he) |
| Title: |
Aspirin and Clopidogrel Resistance. |
| Author: |
Fitzgerald, D.J.; Maree, A. |
| Source: |
IN: Hematology 2007. Washington, DC: American Society of Hematology. 2007. pp. 114-120. |
| Availability: |
Available from American Society of Hematology. 1900 M Street NW, Suite 200, Washington, DC 20036. Email: ASH@hematology.org. Website: www.asheducationbook.org. Price: Available free on website. |
| Abstract: |
This chapter, from the annual Hematology 2007, reviews the use of aspirin and clopidogrel in patients with cardiovascular disease, focusing on patients who experience aspirin and clopidogrel “resistance.” The authors caution that this term infers a lack of therapeutic response and a single underlying mechanism, which is misleading. The incidence of “resistance” detected in clinical studies varies with the definition applied and assay used to measure response. Rather than true resistance, however, there is a variable patient response that reflects the unique pharmacology and pharmacokinetics of each drug, the clinical significance of which remains to be established. The authors discuss true “aspirin resistance” in which, despite 95 percent inhibition of serum thromboxane B2 by aspirin, residual platelet aggregation is detected in some cases. They consider whether heritable factors directly and indirectly related to platelet cyclooxygenase may influence aspirin response. The authors conclude that, in contrast to aspirin, the response to clopidogrel is highly variable and reflects the bioavailability of the active metabolite and not “resistance” of the receptor to inhibition. 2 tables. 46 references. |
| Format: |
Monograph/Book |
| Language: |
English. |
| Major Keywords: |
Hematologic Diseases. Aspirin. Cardiovascular Diseases. Thrombosis. Drug Effects. Patient Care Management. |
| Minor Keywords: |
Clinical Trials. Administration and Dosage. Complications. Platelets. |
| Publication Number: |
HEBK10212 |
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