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Topic: diabetes (dm)
Title: Latent Autoimmune Diabetes in Adults and Pregnancy: Foretelling the Future.
Author: Dunn, J.P.; Perkins, J.M.; Jagasia, S.M.
Source: Clinical Diabetes. 26(1): 44-46. Winter 2008.
Abstract: This case report presents the case of a 25-year-old woman referred for newly diagnosed gestational diabetes mellitus (GDM). Before the pregnancy, her baseline weight was 205 pounds, and her BMI was 33. Overall, she was feeling well and tolerating her pregnancy well. A previous pregnancy, uncomplicated by GDM, had resulted in a healthy, full-term girl who was subsequently diagnosed with type 1 diabetes at age 4. The authors describe the woman’s care, which included the use of bedtime human insulin NPH and close monitoring of blood glucose levels. Insulin lispro was added for mealtime coverage, and her blood glucose control improved on intensive insulin therapy. At term, she delivered a healthy boy by uncomplicated, spontaneous vaginal delivery. Follow-up therapy noted ongoing impaired glucose tolerance, and 4 weeks later the patient experienced symptoms of polyuria, polydipsia, and blurry vision. Her blood glucose values had been between 200 and 350 mg/dl for 3 days. Because of the family history of type 1 diabetes in her daughter and the acute exacerbation of hyperglycemia, an autoantibody test was ordered and she was diagnosed with latent autoimmune diabetes in adults (LADA). Intensive insulin therapy was started with insulin lispro for prandial coverage and insulin glargine for basal coverage. She used an insulin pump and had excellent glycemic control, including through her third pregnancy. The authors use this case to review LADA, how it is diagnosed, and how treatment for LADA varies from that for type 1 or type 2 diabetes. 2 figures. 8 references.

Format: Journal Article
Language: English.
Major Keywords: Diabetes Mellitus. Case Reports. Autoimmune Diseases. Monogenic Diabetes. Symptoms. Diagnosis. Gestational Diabetes. Patient Care Management.
Minor Keywords: Insulin. Administration and Dosage. Risk Factors. Hyperglycemia. Diagnostic Tests. Type 1 Diabetes. Type 2 Diabetes.
Publication Number: DMJA13298
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