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Topic: Diabetes (DM)
Title: Decreased Lung Function in Female but not Male Subjects With Established Cystic Fibrosis-Related Diabetes.
Author: Sims, E.J.; Green, M.W.; Mehta, A.
Source: Diabetes Care. 28(7): 1581-1587. July 2005.
Abstract: Although cystic-fibrosis-related diabetes (CFRD) is associated with decreased lung function, sex is not known to influence CFRD. This article reports on a study that examined the association between female subjects with CFRD and poor lung function relative to male subjects using the percent predicted forced expiratory volume in 1 second (FEV1) as a surrogate measure of morbidity. The authors compared 323 patients with established CFRD with 489 cystic fibrosis control subjects with normal glucose tolerance (NGT) from the United Kingdom Cystic Fibrosis Database. CFRD in female subjects (but not male subjects) without chronic Pseudomonas aeruginosa infection had a 20 percent lower percent predicted FEV1 compared with control subjects with NGT. Genotype, age, treatment center, age at diagnosis of cystic fibrosis, pregnancy, liver function, or dose of pancreatic enzyme replacement therapy did not confound this female disadvantage. Comparison of female subjects with newly diagnosed CFRD free of chronic P. aeruginosa infection with matched control subjects with NGT showed no FEV1 disadvantage in the first year after CFRD diagnosis. The authors conclude that only female subjects with CFRD have significantly decreased lung function compared with sex-matched NGT control subjects. The absence of poor lung function in the first 12 months after diagnosis of diabetes suggests that an opportunity may exist to intervene and possibly prevent a decline in lung function (which can be as much as 20 percent in female subjects with CFRD). 2 figures. 2 tables. 32 references.

Format: Journal Article
Language: English.
Major Keywords: Diabetes Mellitus. Cystic Fibrosis. Respiratory Diseases. Sex Factors. Female. Risk Factors.
Minor Keywords: Epidemiology. Incidence. Etiology. Bacterial Infections. Complications. Lung.
Publication Number: DMJA12335.
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