| Topic: | digestive diseases (dd) |
| Title: | Hyperplastic and Serrated Polyps of the Colorectum. |
| Author: | O'Brien, M.J. |
| Source: | Gastroenterology Clinics of North America. 36(4): 947-968. December 2007. |
| Availability: | Available from The Clinics of North America, W.B. Saunders. 6277 Sea Harbor Drive, Orlando, FL 32887. Phone: 1-800-654-2452. Email: hhspcs@harcourt.com. Website: www.theclinics.com. |
| Abstract: | This article on hyperplastic and serrated polyps of the colorectum is from a special issue of Gastroenterology Clinics of North America that focuses on the pathology and clinical relevance of neoplastic precursor lesions of the gastrointestinal tract, liver, and pancreaticobiliary system. The author notes that the serrated polyp pathway is different from the traditional adenoma-carcinoma sequence. The serrated polyp pathway begins with a hyperplastic polyp, or precursor serrated aberrant crypt focus, and has the potential to end as a colonic adenocarcinoma. The author describes the markers for this pathway, the molecular process, and other serrated pathways. The author concludes by calling for clinical studies to determine the natural history of serrated neoplasia and provide evidence-based guidance for risk assessment and surveillance of patients with various serrated polyp precursors. 5 figures. 100 references. |
| Format: | Journal Article |
| Language: | English. |
| Major Keywords: | Digestive System Diseases. Pathology. Risk Factors. Cancer. Dysplasia. Diagnosis. Lesions. Polyposis. Polyps. Diagnostic Tests. |
| Minor Keywords: | Classification. Diagnostic Tests. Pathogenesis. Tumors. Biopsy. Etiology. Incidence. Genetics. Colon. |
| Publication Number: | DDJA13161 |
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