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| Topic: |
digestive diseases (dd) |
| Title: |
Colonic Polyps in Children and Adolescents. |
| Author: |
Durno, C.A. |
| Source: |
Canadian Journal of Gastroenterology. 21(4): 233-239. April 2007. |
| Abstract: |
This review article considers colonic polyps in children and adolescents, covering isolated juvenile polyps, juvenile polyposis syndrome (JPS), familial adenomatous polyposis (FAP), attenuated familial adenomatous polyposis (AFAP), and mutY homologue (MYH)-associated polyposis (MAP). The author notes that colonic polyps most commonly present with rectal bleeding in children; juvenile refers to the histological type of polyp and not the patient’s age at onset of the polyp. Adolescents and adults with multiple juvenile polyps are at a significant risk of intestinal cancer. Both adult and pediatric gastroenterologists must try to determine the risk of colorectal cancer in people with juvenile polyposis syndrome. AFAP can occur either by a mutation at the extreme ends of the adenomatous polyposis coli gene or by biallelic mutations in the MYH gene. The identification of MYH-associated polyposis as an autosomal recessive condition has important implications for screening and management strategies. The authors conclude with a brief discussion about compliance with surveillance recommendations and future directions. 5 figures. 2 tables. 47 references. |
| Format: |
Journal Article |
| Language: |
English. |
| Major Keywords: |
Digestive System Diseases. Polyps. Colon. Children. Adolescents. Symptoms. Complications. Patient Care Management. |
| Minor Keywords: |
Diagnosis. Screening. Familial Polyposis. Intestinal Polyps. Diagnostic Tests. Rectal Examinations. Colon Cancer. Risk Factors. Genetics. Patient Compliance. |
| Publication Number: |
DDJA12936. |
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