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| Topic: |
digestive diseases (dd) |
| Title: |
Celiac Disease and Autoimmunity in the Gut and Elsewhere. |
| Author: |
Barton, S.H.; Murray, J.A. |
| Source: |
Gastroenterology Clinics of North America. 37(2): 411-428. June 2008. |
| Availability: |
Available from Clinics of North America, W.B. Saunders. 1600 JFK Blvd., Ste 1800, Philadelphia, PA 19103. Phone: 1-800- 654-2452. Email: elspcs@elseview.com. Website: www.gastro.theclinics.com. |
| Abstract: |
This article about celiac disease and autoimmunity in the gut and elsewhere is from an issue of Gastroenterology Clinics of North America that focuses on eosinophilic and autoimmune gastrointestinal disease. Celiac disease is a common immune-mediated enteropathy characterized by sensitivity to the wheat protein, gluten. The authors note that celiac disease is often difficult to diagnose due in large part to the silent form of the disease that affects the majority of patients. Overall mild clinical symptoms with nonspecific complaints such as fatigue, headaches, and arthralgias are common and can delay diagnosis. This article discusses the gut immunogenesis of celiac disease, the role of environmental factors, and the risk of autoimmune disease. The authors focus on the autoimmune connective tissue diseases, endocrine, and dermatologic conditions associated with celiac disease, as well as the related gut inflammatory disorders of refractory celiac disease, autoimmune enteropathy, collagenous enteritis, and collagenous colitis. Specific diseases discussed include Sjogren's syndrome, inflammatory arthritis, Addison's disease, autoimmune insulin-dependent diabetes mellitus (AIDDM), IgA deficiency, pernicious anemia, primary biliary cirrhosis, and autoimmune hepatitis. The authors conclude with a brief discussion of screening recommendations in patient populations with these immune-related illnesses. 1 figure. 2 tables. 79 references. |
| Format: |
Journal Article |
| Language: |
English. |
| Major Keywords: |
Digestive System Diseases. Eosinophilia. Gastrointestinal Diseases. Immune System. Celiac Disease. Pathogenesis. Diagnosis. Patient Care Management. Autoimmune Diseases. |
| Minor Keywords: |
Symptoms. Inflammation. Sjogren's Syndrome. Colitis. Enteritis. Arthritis. Diabetes Mellitus. Anemia. Primary Biliary Cirrhosis. Autoimmune Hepatitis. |
| Publication Number: |
DDJA13250 |
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