| Topic: | digestive diseases (dd) |
| Title: | Complications of Cholestasis. |
| Author: | Patil, A. |
| Source: | IN: Lindor, K.; Talwalkar, J., eds. Cholestatic Liver Disease. Totowa, NJ: Humana Press. 2008. pp 155-170. |
| Availability: | Available from Humana Press. 999 Riverview Dr, Suite 208, Totowa, NJ 07512. Email: humana@humanapr.com. Website: www.humanapress.com. Price: $89.95. |
| Abstract: | This chapter on the complications of cholestasis is from a book that offers health care providers an overview of cholestatic liver disease; cholestasis is defined as a liver disorder characterized by impaired bile flow. The chapter covers osteoporosis, pruritus, dyslipidemia, and vitamin deficiencies. For each condition, the authors discuss prevalence, pathophysiology, and treatment options. Osteoporosis is extremely common in patients with cholestatic liver disease; treatment goals are to prevent further bone loss, thus reducing the risk of fracture. Biphosphonates, hormone replacement therapy, and vitamin K all increase bone mineral density (BMD) and can prevent further bone loss in cholestatic patients. Management of pruritus associated with cholestasis remains challenging because of incomplete understanding of the mechanisms involved and the limited therapies available. Current treatments include reducing bile acid concentration, reducing opioid tonicity, modulating serotonergic activity, and dialysis. The drug treatments commonly used for dyslipidemia remain controversial because of the long-term impact of therapy on vascular events. Because patients with advanced cholestatic liver disease are at risk for vitamin deficiencies, notably of vitamins A and D, screening and treatment are recommended. The authors stress the importance of recognizing the complications of cholestasis because of their prevalence and their pretransplant and posttransplant implications in this patient population. 3 tables. 81 references. |
| Format: | Book Chapter |
| Language: | English. |
| Major Keywords: | Digestive System Diseases. Cholestasis. Liver Diseases. Patient Care Management. Complications. Dyslipidemia. Pruritus. Osteoporosis. Vitamin Deficiencies. |
| Minor Keywords: | Symptoms. Drug Therapy. Diagnostic Tests. Bile. Drug Effects. Cardiovascular System. Vitamins. Bone Diseases. Bone Mineral Density. Quality of Life. Transplantation. |
| Publication Number: | DDBK10907 |
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