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| Topic: |
Digestive Diseases (DD) |
| Title: |
Risk Factors for Inflammatory Bowel Disease in the General Population. |
| Author: |
Wallander, M.A.; Johansson, S.; Gonzalez-Perez, A. |
| Source: |
Alimentary Pharmacology and Therapeutics. 22(4): 309-316. August 15, 2005. |
| Abstract: |
The etiology (cause) of inflammatory bowel disease (IBD, including ulcerative colitis and Crohn’s disease) remains largely unknown. This article reports on a comprehensive assessment of the potential risk factors associated with the occurrence of IBD. The authors identified a cohort of patients 20 to 84 years old between 1995 and 1997 registered in the General Practitioner Research Database in the United Kingdom. A total of 444 new cases of IBD were found and validated with the general practitioner. Analyses showed incidence rates for ulcerative colitis (UC) were 11 cases per 100,000 person-years, for Crohn’s disease were 8 cases per 100,000 person-years, and for indeterminate colitis were 2 cases per 100,000 person-years. Among women, long-term users of oral contraceptives were at increased risk of developing UC. Similarly, long-term users of hormone replacement therapy (HRT) had an increased risk of CD, but not UC. Current smokers experienced a reduced risk of UC along with an increased risk of CD. Prior appendectomy was associated with a decreased risk of UC. Depression and anxiety were associated with a small increased risk of UC. This association was also present among patients with a long-standing (2 years or more) history of these conditions, which supports a hypothetical role of psychological factors in the occurrence of UC. Diabetes and rheumatoid arthritis are independent risk factors of UC and CD, respectively. 1 figure. 3 tables. 14 references. |
| Format: |
Journal Article |
| Language: |
English. |
| Major Keywords: |
Digestive System Diseases. Inflammatory Bowel Disease. Risk Factors. Crohns Disease. Ulcerative Colitis. |
| Minor Keywords: |
Drug Effects. Contraception. Hormones. Drug Therapy. Smoking. Psychological Factors. Diabetes Mellitus. Arthritis. Sex Factors. |
| Publication Number: |
DDJA10524. |
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