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Topic: |
kidney and urologic diseases (ku) |
Title: |
NIDDK Prostate Research Strategic Plan. |
Author: |
Kaplan, S., ed. |
Source: |
Bethesda, MD: National Kidney and Urologic Diseases Information Clearinghouse. 2008. 88 p. |
Availability: |
Available from Available from National Kidney and Urologic Diseases Information Clearinghouse. 3 Information Way, Bethesda, MD 20892. Phone: 1-800-891-5390. Email: nkudic@info .niddk.nih.gov. Website: www.kidney.niddk.nih.gov. Price: Available free of charge on website. |
Abstract: |
Benign diseases of the prostate are among the most common urologic diseases seen by health care professionals. Two of the most significant prostate disorders, based on a variety of troubling symptoms and resulting in diminished quality of life (QOL) of affected males are benign prostate hyperplasia (BPH) and prostatitis. This document presents a blueprint that investigators and the Federal Government can use to identify where the research in this field has been, where the field is now and, most important, where future research efforts should be directed. Not surprisingly, there is overlap in the major sections comprising this document with respect to some topics and recommendations. The document categorizes research efforts into four areas: basic science; epidemiology and population-based studies; translational opportunities; and clinical sciences. BPH, which is often associated with a collection of lower urinary tract symptoms (LUTS), affects men of all races and ethnic groups and can progress in severity over time. If untreated, BPH can lead to significant consequences, such as acute urinary retention, incontinence, and urinary tract infection. Prostatitis affects men of all ages and leads to significant bother and diminished QOL. Prostatitis comprises four categories of acute or chronic disease, including chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Despite its relatively high prevalence—estimates have ranged from 2.7 to 9.7 percent in men 18 years and older—prostatitis remains a poorly understood disorder and is very challenging to treat. Moreover, prostatitis, specifically in its chronic form CP/CPPS, can be physically and psychologically devastating for many patients. Specific research topics considered in this report include: vascular biology, metabolism, inflammation and reactive stroma, stem cells, hormonal effects, animal models, aging, neurobiology, proteomics and new technologies, quality of care, quality of life, costs, serum and tissue biorepositories for prostatic disease, database studies and informatics, histopathology, genetics, measuring disease severity and outcome, drug therapies, phytotherapies, and behavioral and lifestyle interventions. Each section includes figures and tables and numerous references. 14 figures. 6 tables. 151 references. |
Format: |
Monograph/Book |
Language: |
English. |
Major Keywords: |
Urologic Diseases. Prostatic Diseases. Benign Prostatic Hyperplasia. Prostatitis. Research. Guidelines. Clinical Research. |
Minor Keywords: |
Clinical Research. Research Methodology. Government Agencies. Costs. Delivery of Health Care. Quality of Care. Quality of Life. Symptoms. Pathology. Therapy. Patient Care Management. |
Publication Number: |
KUBK11742 |
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