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| Topic: |
kidney and urologic diseases (ku) |
| Title: |
Medical Therapy for Benign Prostatic Hyperplasia. |
| Author: |
Bott, S.R.J.; Foley, C.L.; Kirby, R.S. |
| Source: |
IN: Eardley, I., et al, eds. Drug Treatment in Urology. Williston, VT: Blackwell Publishing Inc. 2006. pp. 21-38. |
| Availability: |
Available from Blackwell Publishing Inc. P.O.Box 20, Williston, VT 05495. Phone: 1-800-216-2522. Email: orders@aidcvt.com. Website: http://www .blackwellpublishing.com. Price: $99.95. |
| Abstract: |
This chapter on medical therapy for benign prostatic hyperplasia (BPH) is from a book that offers a comprehensive summary of the role of pharmacology in urology. The authors note that medical therapy is now widely used as first-line treatment, except in cases of complicated bladder outflow obstruction (BOO) where surgery is more usually performed, or in very mild cases where watchful waiting is the norm. The authors briefly review the epidemiology and natural history of BPH, then discuss alpha-adrenergic antagonists, 5-alpha reductase inhibitors (5ARIs), combination therapy, and phytotherapy-including saw palmetto. The authors conclude that while alpha-blockers have an almost immediate beneficial effect on symptoms and flow, they have no significant impact on the risk of disease progression. By contrast, 5ARIs, when used in men with larger prostates, are capable of both arresting disease progression and reducing the incidence of acute urinary retention (AUR) or the need for BPH-related surgery. The use of both an alpha-blocker and a 5ARI in combination seems appropriate in older men with larger glands and an elevated prostate specific antigen (PSA) score. 4 figures. 3 tables. 46 references. |
| Format: |
Book Chapter |
| Language: |
English. |
| Major Keywords: |
Urologic Diseases. Benign Prostatic Hyperplasia. Drug Therapy. Drug Effects. Pharmacology. Patient Care Management. |
| Minor Keywords: |
Patient Selection. Administration and Dosage. Age Factors. Complications. Alternative Medicine. Symptoms. |
| Publication Number: |
KUBK11564. |
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