Our Science – KewalRamani Website

Vineet N. KewalRamani, Ph.D.

HIV DRP Retroviral Replication Laboratory Head, Model Development Section Investigator Building 535, Room 106 NCI-Frederick Frederick, MD 21702 Phone:   301-846-1249 Fax:   301-846-6777 E-Mail:   vineet@ncifcrf.gov Link: Other Homepage

Biography

Dr. Vineet N. KewalRamani first developed an interest in retroviruses as an undergraduate in the lab of Antonito T. Panganiban at the McArdle Cancer Center, University of Wisconsin at Madison. After choosing to pursue molecular biology as a career, he next went to the University of Washington in Seattle and did his graduate work studying HIV molecular virology in the lab of Michael Emerman at the Fred Hutchinson Cancer Research Center. After completing his Ph.D. in 1996, he moved to New York to join the lab of Dan R. Littman to better understand HIV infection within an immunological context. While working in the Littman lab, Dr. KewalRamani joined in an effort to develop a murine model for HIV replication using transgenic technologies. These studies provided the foundation for his lab's current studies of understanding the blocks to HIV replication in murine cells, identifying human cell cofactors involved in HIV replication, and translating these basic science findings to develop better cell culture and animal models for HIV infection studies.

Research

Examination of Virus-Host Interactions at Molecular, Cellular, and Animal Levels to Better Understand HIV Immunopathogenesis and the Development of Antiviral Resistance

The Model Development Section (MDS) seeks to translate basic research findings to develop model systems that more faithfully mimic human immunodeficiency virus (HIV) infection in vivo. These model systems will be used to investigate questions on viral transmission, viral pathogenesis, and the contribution of the host immune system in these processes. Each research project within the MDS commences with in vitro analyses of viral replication in transformed and primary cell systems. Many of these studies are then complemented by an in vivo component to extend the in vitro findings and explore questions that are only possible within an animal model.

Current projects in the MDS include:

(1) Mechanisms of dendritic cell-mediated HIV transmission with an emphasis on the role of DC-SIGN in this process.

(2) Developing model systems to examine HIV/SIV mucosal transmission and the role of immune system cells in this process.

(3) Identification of the restrictions to HIV replication in mouse and macaque immune cells with a goal to create improved mouse and macaque models to study HIV replication

(4) Macaque models to study the evolution of HIV resistance to antiviral therapy.

Please visit the MDS publications page to see our progress in these various research areas.

Visiting scientists, graduate students, or postdoctoral candidates interested in the possibility of performing research studies in the MDS should contact Dr. Vineet KewalRamani (vineet@ncifcrf.gov). Information for other postdoctoral positions in the HIV DRP can also be found on the Recruitment web page.

This page was last updated on 6/11/2008.