Innate Immune Response
Michael B. Fessler, M.D.
Tel (919) 541-3701
Fax (919) 541-4133
P.O. Box 12233
Mail Drop B2-01
Research Triangle Park, North Carolina 27709
The Host Defense Group investigates the role of cholesterol trafficking and lipid rafts in innate immunity, and uses proteomic and translational approaches to discover and validate novel insights into the innate immune response.
The group uses genetically modified mouse models, lipid raft analysis and signal transduction approaches to define how cholesterol trafficking mechanisms regulate the innate immune response. The research focuses on defining mechanisms of lung inflammation and host defense along with signaling responses of the leukocyte to lipopolysaccharide and related stimuli. A related but independent effort of the laboratory is protein-protein interaction discovery in innate immunity signaling using targeted applications of proteomics. The group will test and validate the results using human specimens obtained in the new Clinical Research Unit.
Major areas of research:
Michael B. Fessler, M.D., head of the Host Defense Group, received an A.B. in philosophy from Princeton University in 1992, a medical degree from Harvard Medical School in 1996 and training in Internal Medicine at Massachusetts General Hospital from 1996-1999 and in Pulmonary/Critical Care Medicine at the University of Colorado from 1999-2002. Fessler developed an expertise in basic and translational approaches to the study of innate immunity, which he expanded during four years of a faculty position at the University of Colorado, before joining the NIEHS in 2006.