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Medicinal Chemistry Group

Basic Research to Therapeutic Applications

Lawrence H. Lazarus, Ph.D.
Lawrence H. Lazarus, Ph.D.
Principal Investigator

Tel (919) 541-3238
Fax (919) 541-5737

Curriculum Vitae (  Download Adobe Reader (155 KB)
P.O. Box 12233
Mail Drop C3-04
Research Triangle Park, North Carolina 27709
Delivery Instructions

Research Summary

The Medicinal Chemistry Group is a leading research program aimed at the development of unique opioid receptor compounds. The long term objective is to translate basic research into clinical and therapeutic applications, such as non-addictive analgesics for relief from chronic and acute pain stemming from trauma, cancer, or surgery, and antagonists to modulate neural reward mechanisms dealing with addiction to opiate drugs, alcohol and food.

The Medicinal Chemistry Group is a constituent member of the Laboratory of Pharmacology whose mission is the combined development of laboratory methods for humans and animals with computational, statistical, and mathematical methods to further the understanding of the mechanisms underlying environmental disease and to provide the linkage between "cutting edge" research in environmental health and the evaluation of health risks from environmental exposures.

Major areas of research

  • Translation of basic research into clinical and therapeutic applications

Current projects

  • Characterization of opioid structure by computational analysis and physicochemical methods
  • Design of opioid ligands by synthetic chemistry and receptor interactions
  • Assessment of receptor interactions and the spectrum of their biological activity in vitro and in vivo

For biographical information on Lawrence H. Lazarus, Ph.D., please see his Curriculum Vitae.

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Last Reviewed: January 09, 2009