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Aspirin overdose

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Alternative Names   

Acetylsalicylic acid overdose

Definition    Return to top

An overdose of aspirin means you have too much aspirin in your body.

This can happen in two ways:

If a person accidentally or intentionally takes a very large dose of aspirin at one time, it's called an acute overdose.

If a normal daily dose of aspirin builds up in the body over time and causes symptoms, it's called a chronic overdose. This may happen if your kidneys do not work correctly or when you are dehydrated. Chronic overdoses are usually seen in older patients during hot weather.

Poisonous Ingredient    Return to top

Acetylsalicylic acid

Where Found    Return to top

Acetylsalicylic acid (aspirin) can be found in many prescription and over-the-counter pain relievers, including:

Note: This list may not be all inclusive.

Symptoms    Return to top

Symptoms of acute overdose may include:

Symptoms of chronic overdose may include:

Large overdoses may also cause:

Before Calling Emergency    Return to top

Determine the following information:

Poison Control    Return to top

The National Poison Control Center (1-800-222-1222) can be called from anywhere in the United States. This national hotline number will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the U.S. use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

Take the container with you to the emergency room.

What to Expect at the Emergency Room    Return to top

The health care provider will check your temperature, pulse, breathing rate, and blood pressure. An intravenous (IV) line will be placed into a vein. Lab tests, including an arterial blood gas test, will be done.

Treatment depends on the amount of aspirin, the time you swallowed it, and your overall condition when you reach the emergency room. You may receive:

Other medicines may be given through a vein, including potassium salt and sodium bicarbonate, which helps the body remove aspirin that has already been digested.

If these treatments do not work or the overdose is extremely severe, hemodialysis may be needed to remove aspirin from your blood.

Very rarely, a breathing machine may be needed. But many poisoning experts think this causes more harm than good, so it is only used as a very last resort.

Outlook (Prognosis)    Return to top

Taking more than 150mg/kg of aspirin can have serious and even deadly results if untreated. For a small adult, that's roughly equal to taking 20 tablets containing 325mg aspirin. Much lower levels can affect children.

If treatment is delayed or the overdose is large enough, symptoms will continue to get worse. Breathing becomes extremely fast or may stop. Seizures, high fevers, or death may occur.

How well you do depends greatly on how much aspirin your body has absorbed -- and how much is flowing through your blood. If you take a large amount of aspirin but come quickly to the emergency room, treatments may help keep your blood levels of aspirin very low. If you do not get to the emergency room fast enough, the level of aspirin in your blood can become dangerously high.

References    Return to top

Ford MD. Clinical Toxicology. 1st ed. Philadelphia, Pa: WB Saunders; 2001.

Marx J. Rosen’s Emergency Medicine: Concepts and Clinical Practice. 6th ed. St. Louis, Mo: Mosby; 2006.

Update Date: 2/28/2007

Updated by: Eric Perez, MD, Department of Emergency Medicine, St. Luke's-Roosevelt Hospital Center, New York, NY. Review provided by VeriMed Healthcare Network.

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