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Cartoon scientist reading about IACUC Your IACUC is an oversight body appointed by an official at your domestic institution, such as the chief executive officer. The Office of Laboratory Animal Welfare relies on the IACUC to enforce PHS policy and your institution's animal policies.

IACUCs do the following:

  • Review and approve animal use protocols, including significant changes to previously approved protocols.
  • Monitor your animal care and use program, including a semi-annual inspection of animal facilities.
  • Hold orientation programs on institutional animal policies and procedures, e.g., what is expected, which protocol forms to use, and where to get animals.
  • Evaluate compliance with institutional policies.
  • Report annually and notify OLAW of suspensions and instances of serious noncompliance with policy. See the February 24, 2005, Guide notice for guidance on what an IACUC should report to OLAW.

Find out your institution's policies before you plan your research. In most institutions, policies for research animals are a combination of institutional and USDA and PHS requirements. Some are more stringent than others, so a procedure you performed at another institution may not be acceptable at your current workplace.

IACUC Requirements Vary for Domestic and Foreign Institutions

Identify your situation below for a summary of IACUC requirements.

  • Domestic grantees with no foreign subawards
    • Follow all the IACUC requirements outlined in this tutorial and by OLAW.
  • Domestic grantees with a foreign subaward
    • The domestic institution's IACUC reviews and approves the animal protocol in the application.
    • Both institutions must have an OLAW assurance.
    • The foreign subawardee should also follow the instructions in the next section.
  • Foreign grantees and subawardees
    • Your institution doesn't need its own IACUC unless required by local law.
    • Your institution must have an OLAW assurance.
    • You must complete a “Statement of Compliance with Standards for Humane Care and Use of Laboratory Animals by Foreign Institutions.”

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