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Research
Laboratory of Structural Biology Research
Senior Investigator
Phone: 301-496-0132
Building: 50, Room: 1517
E-mail: stevena@mail.nih.gov
Alasdair Steven received his M.A. in Mathematics from the University of Edinburgh and then took Part III of the Mathematical Tripos and a Ph.D. in theoretical physics from the University of Cambridge. He then switched to molecular biology, spending five years as a postdoctoral fellow with Prof. Eduard Kellenberger at the University of Basel, during which time he earned a Swiss Certificate in Molecular Biology. In 1978, he was appointed to a tenure-track position at the NIH and started a small group specializing in computer-enhanced electron microscopy, which has since grown considerably and in 1990 was converted into the Laboratory of Structural Biology Research. Dr Steven is past chair of the Gordon Conference on Three-dimensional Electron Microscopy of Biological Macromolecules, the FASEB Conference on Virus Assembly, and the 15th International Conference on Bacteriophage and Virus Assembly. He also serves as Editor-in-Chief of the Journal of Structural Biology.
Other NIAMS Affiliations
Laboratory of Skin Biology
Selected Publications
Tang SX, Murakami T, Cheng NQ, Steven AC, Freed EO, Levin JG. Human immunodeficiency virus type 1 N-terminal capsid mutants containing cores with abnormally high levels of capsid protein and virtually no reverse transcriptase. Journal of Virology 2003; 77(23): 12592-602
Heymann JB, Cheng N, Newcomb WW, Trus BL, Brown JC, Steven AC. Dynamics of herpes simplex virus capsid maturation visualized by time-lapse cryo-electron microscopy. Nat Struct Biol. 2003; 10(5):334-41.
Grunewald K, Desai P, Winkler DC, Heymann JB, Belnap DM, Baumeister W, Steven AC. Three-dimensional structure of herpes simplex virus from cryo-electron tomography. Science. 2003; 302(5649): 1396-8.
Conway JF, Watts NR, Belnap DM, Cheng N, Stahl SJ, Wingfield PT, Steven AC. Characterization of a conformational epitope on hepatitis B virus core antigen and quasiequivalent variations in antibody binding. J Virol. 2003; 77(11): 6466-73.
Belnap DM, Watts NR, Conway JF, Cheng N, Stahl SJ, Wingfield PT, Steven AC. Diversity of core antigen epitopes of hepatitis B virus. Proc Natl Acad Sci U S A. 2003; 100(19):10884-9.
