Laboratory of Human Bacterial Pathogenesis

Frank DeLeo, Ph.D., Acting Chief

The Laboratory of Human Bacterial Pathogenesis (LHBP) studies the molecular basis of human bacterial pathogenesis in its broadest sense. Research projects currently focus on the Staphylococcus-host interactions, with special emphasis on the virulence mechanisms of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA).

LHBP scientists study mechanisms of staphylococcal virulence, innate immune response to pathogenic bacteria, and the role of neutrophils in host defense. In addition, mechanisms of immune evasion, such as the formation of biofilms, are a major area of investigation. Genome-wide strategies are used, such as high-throughput DNA sequencing and expression array analysis.

Goals

• Understand the fundamental molecular mechanisms of bacterial pathogen-host interactions
• Develop new or improved strategies to control bacterial infections
• Identify host genetic factors influencing disease character
• Define the cell biology of pathogen-host interactions

Office of the Chief

Frank DeLeo, Ph.D., Acting Chief

Pathogen-Host Cell Biology Section

Frank R. DeLeo, Ph.D. 

Pathogen Molecular Genetics Section

Michael Otto, Ph.D.

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