Laboratory of Clinical and Translational Studies (LCTS)

Mission Statement

Uses translational strategies, integrating rodent, primate and human studies, to investigate genetic susceptibility and neuroadaptive processes underlying the development of alcohol dependence and related phenotypes;
conducts studies aimed at identifying potential molecular and behavioral targets for novel treatments;
develops and applies, using behavioral, neuroendocrine, molecular and functional imaging methodology, short term models predictive of clinical efficacy in treating various aspects of alcoholism and affective dysregulation;
carries out small scale proof-of-concept clinical treatment trials to evaluate the clinical efficacy of candidate targets identified by the described apporoaches;
trains investigators in research techniques carried out by the laboratory; and
collaborates with organizations outside of the Institute in investigations related to mechanisms of alcohol dependence and treatment development.

Staff

Section
Office of the Chief
Section of Brain Electrophysiology and Imaging
Section of Clinical Assessment and Treatment Evaluation
Section of Molecular Pathophysiology
Unit on Human Physiology and Pharmacokinetics