[LIRR Membership Roster] [LIRR Meeting Rosters]

The Lung Injury, Repair, and Remodeling [LIRR] Study Section reviews applications that focus on lung injury, repair, remodeling, and barrier function in non-vascular pulmonary tissue or cells, and lung development and regeneration. Among the mechanistic processes considered are cellular processes including signal transduction, control of gene expression, cell cycle and cell death mediators, and proteolytic mechanisms. Integrative processes include inflammation, cell trafficking, cell-cell interactions, regulation of extracellular matrix, and effects of blood components such as coagulation factors and complement. Specific areas covered by LIRR:

• Lung injury: Includes, but not limited to lung injury caused by reactive oxygen and nitrogen species, hypoxia, sepsis, mechanical ventilation, alcohol, and environmental and other toxic agents. This would include studies addressing lung epithelium injury, leukocyte contributions to lung injury, normal and abnormal lung permeability, and mechanisms of resolution, repair, and remodeling.
• Pulmonary fibrosis and interstitial lung diseases: Includes granulomatous diseases (such as sarcoidosis), idiopathic pulmonary fibrosis, interstitial pneumonias, autoimmune lung diseases, and lymphangioleiomyomatosis. This would also include involvement of mesenchymal stem cells, epithelium dysfunction, and epithelial-mesenchymal transition.
• Lung fluid balance: Includes epithelial (ion channels, aquaporins, etc.), interstitium, and lymphatic function and pulmonary edema, when not primarily restricted to the pulmonary vasculature.
• Pleural diseases: Includes infections, dysplasias, hyperplasias, and other non-malignant proliferative disorders and inflammatory processes.
• Lung development and maturation: Includes mechanisms of normal and abnormal lung development, differentiation, and neonatal and pediatric lung syndromes and diseases (e.g. meconium aspiration syndrome and bronchopulmonary dysplasia).
• Stem cells: Includes stem cell biology in the context of lung development and repair/regeneration. This includes isolation and characterization of lung progenitor cells, development of in vitro culture systems that allow expansion of lung progenitor cells and differentiation of embryonic stem cells and adult stem cells into lung epithelium, endothelium, and other components of the respiratory system, tissue engineering, and stem cell based therapy.
• Pulmonary surfactant: Includes expression and post-translational processing and trafficking of surfactant proteins A, B, C and D in lung epithelium, surfactant lipids, lung diseases associated with surfactant dysfunction and/or deficiency, and surfactant replacement therapy.
• Environmental and occupational lung diseases and inhalation and respiratory toxicology.

Study sections with most closely related areas of similar science listed in rank order are:

Lung Cellular, Molecular, and Immunology [LCMI] 
Respiratory Integrative Biology and Translational Research [RIBT] 
Systemic Injury by Environmental Exposure [SIEE] 
Surgery, Anesthesiology, and Trauma [SAT] 
Genetics of Health and Disease [GHD]