Scientific Area of Research
Neurological disorders may result when extra-neuronal cells are compromised, as in demyelinating and cerebrovascular diseases;
when extra-neuronal cells themselves become aggressors, as in inflammatory responses within the nervous system, when viruses,
bacteria, or parasites infect the cells of the nervous system, when autoimmune responses damage nerve and muscle; when cells
of the blood-brain barrier are dysfunctional, or when glial dysfunction in the developing nervous system results in developmental
abnormalities. Glial cells, microvascular endothelia, and cells of hematopoetic origin are integrally involved in the normal
development and/or functioning of the nervous system and play a crucial role in disease. Emerging concepts on the interaction
among all of these cells hold great promise for increasing our understanding of how the nervous system works in normal and
diseased states, and will broaden our perspective on how we think about the nervous system.
The Neural Environment cluster promotes translating scientific knowledge into useful diagnostic tools, research on the implementation
of preventive measures, and development and delivery of targeted therapeutic agents for neurological diseases.
Current Funding Announcements
*Note: The
Electronic Submission process for grant applications has begun at NIH. Register with
Grants.gov and
NIH eRA Commons so that you may
start preparing for this transtion
Funding announcement information is updated daily throughout the NINDS website. If individual funding announcements are not
listed below, it means that there are no current solicitations available for this particular Program Area. Please continue
to check this web page for the latest RFA's, PA's, RFP's and Notices related to this Program Area.
Requests for Application (RFA)
(Sorted by Application Receipt Date)
Program Announcements (PA)
(Sorted by Application Receipt Date)
-
Sarcoidosis: Research into the Cause of Multi-organ Disease and Clinical Strategies for Therapy (R01) [Summary]
Application Receipt Date: February 5, 2009
Announcement Number: PA-07-136
Funding Contact:
May Wong, Ph.D.
Program Area:
Neural Environment
-
Research Supplements to Promote Diversity in Health-Related Research [Summary]
Application Receipt Date: February 15, 2009
Announcement Number: PA-08-190
Funding Contact:
Michelle Jones-London, Ph.D.
Program Area:
Neural Environment, Neurodegeneration, Neurogenetics, Repair and Plasticity, Office of Minority Health and Research, Channels, Synapses and Neural Circuits, Systems and Cognitive Neuroscience, Office of Clinical Research
-
Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers [Summary]
Application Receipt Date: February 15, 2009
Announcement Number: PA-08-191
Funding Contact:
Michelle Jones-London, Ph.D.
Program Area:
Neural Environment, Neurodegeneration, Neurogenetics, Repair and Plasticity, Office of Translational Research, Office of Minority Health and Research, Channels, Synapses and Neural Circuits, Systems and Cognitive Neuroscience, Office of Clinical Research
-
Specialized Programs of Research Excellence (SPOREs) in Human Cancer for the Year 2008 and 2009 (P50) [Summary]
Application Receipt Date: May 22, 2009
Letter of Intent Date: April 21, 2009
Announcement Number: PAR-08-020
Funding Contact:
Jane Fountain, Ph.D.
Program Area:
Neural Environment
Notices (NOT)
(Sorted by Release Date)
-
NIH/AHRQ Confirms Plans to Transition the G7, G8, G11, G13, G20, S11, S21 and S22 to Electronic Applications and Announces
Delay in Transition of K, F, T and Complex Grant Programs [Summary]
Release Date: January 19, 2007
Announcement Number: NOT-OD-07-038
Funding Contact: NINDS Funding
Program Area:
Neural Environment, Neurodegeneration, Neurogenetics, Repair and Plasticity, Office of Translational Research, Office of Training and Career Development, Office of Minority Health and Research, Channels, Synapses and Neural Circuits, Systems and Cognitive Neuroscience, Office of Clinical Research
-
Policy Revision of the National Institute of Neurological Disorders and Stroke (NINDS) for Competing Program Project (P01)
and Unsolicited Center Grant (P50) Applications [Summary]
Release Date: May 15, 2007
Announcement Number: NOT-NS-07-010
Funding Contact:
Robert Finkelstein, Ph.D.
Program Area:
Neural Environment, Neurodegeneration, Neurogenetics, Repair and Plasticity, Office of Translational Research, Office of Training and Career Development, Office of Minority Health and Research, Channels, Synapses and Neural Circuits, Systems and Cognitive Neuroscience, Office of Clinical Research
-
Amendment to NOT-NS-07-010: Policy Revision of the National Institute of Neurological Disorders and Stroke (NINDS) for Competing
Program Project (P01/P50) Grant Applications [Summary]
Release Date: February 6, 2008
Announcement Number: NOT-NS-08-010
Funding Contact:
Emmeline Edwards, Ph.D.
Program Area:
Neural Environment, Neurodegeneration, Neurogenetics, Repair and Plasticity, Office of Translational Research, Office of Training and Career Development, Office of Minority Health and Research, Channels, Synapses and Neural Circuits, Systems and Cognitive Neuroscience, Office of Training and Career Development, Office of Clinical Research
Administrative and Research Supplements
(Sorted by Release Date)
View Archived AnnouncementsAdditional Information
Mission:
The mission of the Neural Environment Cluster is to reduce the burden of neurological diseases by facilitating research that
increases knowledge of glial and cerebrovascular cell function in normal and pathological states, as well as immune cell function
and infectious agents in the diseased nervous system.
The NINDS Neural Environment Cluster facilitates research on the neural environment by:
- To encourage studies on the role of diverse cell populations of the nervous system and mechanisms of cell-cell interaction
responsible for the normal function and maintenance of the nervous system as an organ, including the function of glial cells,
brain blood supply, and CSF flow.
- To encourage research on infectious, immune, and inflammatory mechanisms in nervous system disorders such as multiple sclerosis,
prion diseases, stroke, CNS and PNS tumors, and neuroAIDS.
- To encourage studies to identify the molecular mechanisms of cell injury and death in the nervous system.
- To foster studies on vascular mechanisms of neurological disorders, CNS vascular development, and the role of microvascular
endothelia, extracellular matrix, and cells of hematopoietic origin within the CNS.
- To promote the development of diagnostics and of therapies that will prevent, arrest, or reverse autoimmune neurological disorders
such as multiple sclerosis.
- To expand studies on the mechanisms of blood-brain and brain-CSF barrier functions and of cell migration (and/or trafficking)
into the CNS in stroke, immune disorders, brain tumors, and CNS infections.
- To encourage the development of animal models for infectious and immune disorders, CNS and PNS tumors, and stroke (e.g., transgenic
or knockout/in models, viral models).
- To encourage the study of normal glial or progenitor/stem cell populations and their role in the development or treatment
of CNS and PNS tumors.
- To promote the study of biomarkers for vascular, tumorigenic, and immune diseases of the nervous system.
- To strongly encourage bi-directional translational research that transfers insights gained from basic research and clinical
investigations.
Major Program Portfolios include:
Stroke
Multiple Sclerosis
Neuro-AIDS
Prion Diseases
Encephalitis
NIH-Supported Clinical Trials in Neural Environment Areas:
Quick Links
Workshops and Summaries
NeuroAIDS in the Asia-Pacific Region July 19, 2007
Selective Adhesion Molecule Inhibitors and CNS Disease July 26, 2005
Biomarkers in Multiple Sclerosis - Workshop Summary April 14-16, 2004
Genetics and Multiple Sclerosis: Future Prospects September 8-10, 2003
Astrocyte Function in Health and Disease September 23 - 25, 2002
International Workshop on Brain Banking March 11-12, 2002
NIH Myositis Outcomes Workshop November 9 - 10, 2001
Workshop on Research Opportunities on Human Neuroborreliosis September 9 - 12, 2001
NINDS Health Disparities Planning Panel on NeuroAIDS in Minority Populations July 16, 2001
Multiple Sclerosis and Chemokines: Prospects for Therapeutic and Prophylactic Intervention July 9 - 10, 2001
Personnel
Address
Neural Environment
Neuroscience Center
Room NSC 2110
6001 Executive Blvd.
Bethesda, Maryland 20892-9521
For courier service only, use Rockville, Maryland 20852
Call: (301) 496-1431