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#490Structural Biology Laboratory
 
Description:
This session is intended as a laboratory follow-up for attendees of the Structural Biology Lecture Series. The session will be an open laboratory in which attendees bring their own structural biology problems. Drs. Darrell Hurt and Michael Dolan from the NIAID Bioinformatics and Scientific IT Program (BSIP) will be available to assist attendees with information on the use of Structural Biology software and provide suggestions. Software covered in the course included:


Structural Biology Viewers
  • Pymol
  • DeepView
  • Chimera
  • VMD

Structural Biology Databases<
  • PDB
  • ModBase
  • Genomic Threading Database
  • Dali, VAST, SSM

Structural Biology Web Servers
  • SWISS-MODEL, CPHmodels 2.0, 3D-JIGSAW, ESyPred3D, PS2, PHYRE
  • PredictProtein, SAM, PSIPRED, JUFO
  • PROSPECT, GenTHREADER, LOOPP
  • HEX, PatchDock, DOT, ZDOCK
  • MolProbity
  • DomPred, GINZU

Rosetta
  • Structure Prediction
  • Loop Modeling
  • Protein Docking

Molecular Dynamics
  • Servers: HEX, PatchDock/FireDock/SymmDock, RosettaDock
  • Validation: KFC hot-spot finder, iMolTalk, LPC CSU

This is a follow-up to the lecture series on computational structural biology presented by the NIAID Bioinformatics and Scientific IT Program. Please click on the following links to view and/or register for the other lectures.

Protein Structure Analysis: Introduction and Visualization

Introduction to Homology Modeling: Sequence Alignment and Template Selection

Advanced Homology Modeling: Model Optimization, Alignment Improvement (Threading), Protein Complexes

Loop Modeling and Protein Folding: Rosetta, Secondary Structure Predictions, Structure Validation, Database Mining

Protein-Protein Docking: Complexes Revisited, Constraints, Multi-domain Proteins

in silico Drug Screening: Small Molecule Docking

Molecular Dynamics: Macromolecular Simulations

Protein and Interface Design: A Real-world Example - Antibody Design, Publication-Quality Graphics

 
Who should attend:
NIH staff with Structural Biology research problems who have either attended the Structural Biology Lecture Series or have used some of the programs covered and would like advice or consultation.
 
Instructor(s):
Dr. Darrell Hurt, Ph.D., NIAID OCICB Bioinformatics and Computational Biosciences Branch (BCBB)
 
Time Required:
2 hours
 
Sections Available:
-- Concluded -- 490-09F December 10 9:00 - 11:00 Building 12A, Room B51
 
NOTE: Although this course has already taken place, we'll put you on a waiting list for the next available session.

Course Listing

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