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#487Loop Modeling and Protein Folding: Rosetta, Secondary Structure Predictions, Structure Validation, Database Mining
 
Description:
The course will cover:

  • Secondary structure predictions
    • Chou-Fasman, GOR, PHD, PSIPRED, JUFO, SAM

  • Rosetta
    • Theory: Monte Carlo methods and fragment-based assembly
    • Evaluation criteria
    • Protocols: Protein folding and loop modeling
    • Automatic servers

  • Alternative methods: Bhageerath, I-TASSER

This is the forth lecture in a nine-part series on computational structural biology presented by the NIAID Bioinformatics and Scientific IT Program. Please click on the following links to view and/or register for the other lectures.

Protein Structure Analysis: Introduction and Visualization

Introduction to Homology Modeling: Sequence Alignment and Template Selection

Advanced Homology Modeling: Model Optimization, Alignment Improvement (Threading), Protein Complexes

Protein-Protein Docking: Complexes Revisited, Constraints, Multi-domain Proteins

in silico Drug Screening: Small Molecule Docking

Molecular Dynamics: Macromolecular Simulations

Protein and Interface Design: A Real-world Example - Antibody Design, Publication-Quality Graphics

Structural Biology Laboratory


 
Who should attend:
NIH staff who work with protein modeling and would like to know more about the context.
 
Instructor(s):
Dr. Darrell Hurt, Ph.D., NIAID OCICB Bioinformatics and Computational Biosciences Branch (BCBB)
 
Time Required:
2 hours
 
Sections Available:
-- Concluded -- 487-09F October 15 9:00 - 11:00 Building 12A, Room B51
 
NOTE: Although this course has already taken place, we'll put you on a waiting list for the next available session.

Course Listing

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