mRNA Stability & Translation
Traci M. T. Hall, Ph.D.
Tel (919) 541-1017
Fax (919) 316-4617
email@example.com P.O. Box 12233
Mail Drop F3-05
Research Triangle Park, North Carolina 27709
The Macromolecular Structure Group uses structural biology and biochemical approaches to study post-transcriptional and translational gene regulation and RNA: protein interactions.
Specifically, the group is studying Puf family RNA-binding proteins and proteins involved in RNA interference. Puf proteins contain an RNA-binding domain comprising eight sequence repeats and regulate gene expression by modulating mRNA stability or translation. In addition to understanding the mechanism of RNA sequence specificity, the Puf proteins are being used as templates to create designed RNA proteins that can be used to affect gene expression. The group also studies proteins involved in RNA interference through work on viral proteins that inhibit RNA silencing as well as proteins involved in processing small interfering RNA and microRNA.
Major areas of research:
Traci M.T. Hall, Ph.D., is a tenured principal investigator leading the Macromolecular Structure Group within the Laboratory of Structural Biology. She earned her B.S. in biochemistry from the University of California, Los Angeles, and her Ph.D. in pharmacology and molecular sciences from the Johns Hopkins University School of Medicine. She was a AAAS Diplomacy Fellow with the U.S. Agency for International Development and a postdoctoral fellow with Daniel J. Leahy at Johns Hopkins before joining the NIEHS in 1998.