NINDS ADMINISTRATIVE SUPPLEMENTS FOR DNA MICROARRAY ANALYSIS RELEASE DATE: October 30, 2003 NOTICE: NOT-NS-04-002 National Institute of Neurological Disorders and Stroke (NINDS) (http://www.ninds.nih.gov) The National Institute of Neurological Disorders and Stroke (NINDS) announces an administrative supplement program of up to $1.0 million in Fiscal Year 2004 to provide funds to NINDS-funded research projects to conduct gene expression profiling experiments on the nervous system. This program is intended to facilitate access to DNA microarray analysis for peer-reviewed projects that have Specific Aims for which microarray analysis will provide clearly relevant data. The supplemental funds may be used to execute primary experiments and isolate RNA in the grantee labs, and to purchase products and services from the NINDS/NIMH Microarray Consortium. Animals and supplies may be requested for the home lab, with the remainder of the funds reserved for use of the microarray consortium. No requests for salary or equipment will be considered. Opportunities are available for investigators to visit the microarray centers to use the facilities for sample processing, including RNA extraction, amplification of small amounts of RNA, and laser-capture microdissection. In cases where the research plan involves one or more visits to a consortium microarray center, travel funds for the visits may be requested. Principal Investigators (PIs) with Research Project (R01 or U01), Exploratory/Developmental (R21), Phase II SBIR (R44), Program Project (P01), and Specialized Center (P50 or U54) grants are eligible to apply. To be eligible, projects must be actively funded in fiscal year 2004. Evidence should be presented that the results of the supplemental assistance will significantly enhance the pursuit of the Specific Aims of the research project, without constituting an expansion of scope. The NINDS/NIMH Microarray Consortium was established to serve as a national resource to provide DNA microarray products and services to NINDS and NIMH grantees, on a fee-for-service basis. The consortium is composed of three microarray centers, located at Duke University in Durham, NC, the Translational Genomics Research Institute in Phoenix, AZ, and the University of California in Los Angeles, CA. The full spectrum of support for microarray studies is available through the consortium, including advice on experimental design, education and training of investigators, hybridization and scanning of arrays, bioinformatics support, and manuscript preparation assistance. The consortium makes and provides spotted oligonucleotide and cDNA arrays, and supports the Agilent and Affymetrix platforms. Further information on the microarray consortium is available on the consortium website (http://arrayconsortium.tgen.org), or by contacting the Consortium Coordinator, Sarah Brautigam, at 602-343-8732 or SBrautigam@tgen.org. It is recommended that investigators contact the consortium in advance of preparing research plans or formulating budget requests to get preliminary advice on experimental design and to determine the approximate cost of using the consortium for the supplemental study. How to Make a Request: Applicants should submit an original and three complete copies to the NINDS program contact listed at the end of this Notice. The following sections should be included: 1) A cover page citing this Notice and including the PI name, grant number and title, amount of the requested supplement, the name and title of the institutional official, and the phone, email, and address information for both the PI and institutional official. Document the approval from the Institutional Animal Care and Use Committee (IACUC) for any use of vertebrate animals in the supplemental experiments. For P01s, P50s, and U54s, the PI must submit a request for a supplement to a subproject. The cover page must be signed by the PI and the institutional official. 2) A letter (5-page limit) describing the project, including an abstract, a description of the proposed experiments and their relationship to the original project Specific Aims, a discussion of the significance of the results, and a budget. 3) A Biographical Sketch of the PI. 4) The Specific Aims from the grant. 5) Documentation of institutional or other co-funding. Budget Information: Supplements will be made in modular amounts of $25,000. All awards are TOTAL COSTS. Any Facilities & Administrative Costs (indirect costs) should be included in the modular request, and cannot be requested in addition to the modular amounts. For all grant mechanisms the maximum supplement is $50,000. Although the awarded budgets will be modular, applicants should provide a categorized budget justification. Contributions from institutional and other sources may be combined with the requested award; such contributions should be documented. Review Procedure: Applications will be reviewed administratively. Review criteria will be considered in the context of the Specific Aims of the parent grant and will include the scientific merit of the proposed study, the relevance to program priorities of NINDS, and the impact of the results for other areas in neuroscience. It is anticipated that supplements will be awarded within four months of the receipt date. RECEIPT DATE: February 17, 2004 Inquiries should be directed to: Thomas Miller, Ph.D. Technology Development National Institute of Neurological Disorders and Stroke 6001 Executive Boulevard, Room 2139 Bethesda MD 20892 Tel: 301-496-1779 Fax: 301-402-1501 Email: tm208y@nih.gov
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