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Selected Publications

Molecular Developmental Biology Group

  1. Yuhki, M., Yamada, M., Kawano, M., Iwasato, T., Itohara, S., Yoshida, H., Ogawa, M., and Mishina, Y.: BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice. Development. 131: 1825-1833, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15084466) Exit NIEHS
  2. Stottmann, R. W., Choi, M., Mishina, Y., Meyers, E. N., and Klingensmith, J.: BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium.  Development. 131: 2205-2218, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15073157) Exit NIEHS
  3. Andl, T., Ahn, K., Kairo, A., Chu, E. Y., Wine-Lee, L., Reddy, S. T., Croft, N. J., Cebra-Thomas, J. A., Metzger, D., Chambon, P., Lyons, K. M., Mishina, Y., Seykora, J. T., Crenshaw III, E. B., and Millar, S. E.: Epitherial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development. 131: 2257-2268, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15102710) Exit NIEHS
  4. Ye, L., MacDougall, M., Zhang, S., Xie, Y., Li, Z., Zhang, J., Lu, Y., Fisher, L. W., Mishina, Y., and Feng, J. Q.:Deletion of Dentin Matrix Protein-1 Leads to a Partial failure of maturation of predentin into dentin, hypomineralization and expanded cavities of pulp and root canals during postnatal tooth development. J. Biol. Chem. 279: 19141-19418, 2004.[Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14966118) Exit NIEHS
  5. Qi, X., Li, T. G., Hao, J., Hu, J., Wang, J., Simmons, H., Miura, S., Mishina, Y., and Zhao, G. Q.: BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc. Natl. Acad. Sci. USA. 101: 6027-6032, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15075392) Exit NIEHS
  6. Mishina, Y., Starbuck, M.W., Gentile, M. A., Fukuda, T., Seedor, G. J., Hanks, M.C., Amling, M., Harada, S., Pinero, G. J., and Behringer, R.R.: Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling. J. Biol. Chem. 279:27560-27566, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15090551) Exit NIEHS
  7. Davis, S., Miura, S., Hill, C., Mishina, Y., and Klingensmith, J.: BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning.  Dev. Biol. 270: 47-63, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15136140) Exit NIEHS
  8. Stumpo, D. L., Phillips, R. S., Maronpot, R. R., Castranio, T., Byrd, N., Meyers, E. N., Mishina, Y., and Blackshear, P. J.: Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the tristetraprolin family. Mol. Cell. Biol. 24: 6445-6455, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15226444) Exit NIEHS
  9. Hu, J., Chen, Y.-X., Wang, D., Qi, X., Li, T.-G., Hao, J., Mishina, Y., Garbers, D. L., and Zhao, G.-Q.: Developmental expression and function of Bmp4 in spermatogenesis and in maintaining epididymal integrity. Dev. Biol. 276:158-171, 2004. (Published online September 16, 2004) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15531371) Exit NIEHS
  10. Kishigami, S., Yoshikawa, S., Castranio, T., Okazaki, K., Furuta Y., and Mishina, Y.: BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo. Dev. Biol. 276:185-193, 2004. (Published online September 18, 2004) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15531373) Exit NIEHS
  11. He, X., Zhang, J., Tong, W. G., Tawfik, O., Ross, J., Scoville, D. H., Tian Q., Zeng, X., He, X., Wiedemann, L. M., Mishina, Y., and Li, L.: BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat. Genet. 36:1117-1121, 2004.  (online September 19, 2004.) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15378062) Exit NIEHS
  12. Rountree, R.B., Schoor, M., Chen, Hao, Marks, M. E., Mishina, Y., and Kingsley, D. M.: BMP receptor signaling is required for postnatal maintenance of articular cartilage.  PLoS Biology.  2:e355, 2004. (Published online October 19, 2004) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15492776) Exit NIEHS
  13. Wine-Lee, L., Ahn, K. .J, Richardson, R. D., Mishina, Y., Lyons, K. M., and Crenshaw III, E. B. Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord. Development. 131:5393-5403, 2004.  (Published online Oct 6, 2004.) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15469980) Exit NIEHS
  14. Ye, L*, Mishina, Y.*, Chen, D., Huang, H., Dallas, S., Dallas, M., Kunieda, T., Tsutsui, T. W., Boskey, A. L., Bonewald L. F. and Feng, J. Q.:Dmp1-Deficient Mice Display Severe Defects in Cartilage Formation and a Chondrodysplasia-like Phenotype.  J. Biol. Chem. 280:6197-6203, 2005. (Published online Dec. 7, 2004.) *Equally contributed. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15590631) Exit NIEHS
  15. Murali, D., Yoshikawa, S., Corrigan, R., Plas, D. J., Crair, M. C., Oliver, G. C., Lyons, K. M., Mishina, Y., and Furuta, Y.: Distinct developmental programs that require differential levels of BMP signaling during mouse retinal development.  Development. 132:913-923, 2005. (Published online Jan. 26, 2005.) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15673568) Exit NIEHS
  16. Liu, W., Sun, X., Braut, X., Mishina, Y., Behringer, R. R., Mina, M., and Martin, J. F.: Distinct functions for BMP-signaling in lip and palate fusion in mice. Development. 132:1453-1461, 2005. (Published online Jan. 26, 2005.) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15716346) Exit NIEHS
  17. Yoon, B. S., Ovchinnikov, D. A., Yoshii, I., Mishina, Y., Behringer, R. R. and Lyons. K. M.: Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc. Natl. Acad. Sci. USA.  102:5062-5067, 2005. (Published online Mar. 21, 2005.) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15781876) Exit NIEHS
  18. Fukuda, T., Mishina, Y., Walker, P. M., and DiAugustine, R. P.: Conditional transgenic system for mouse Aurora A kinase: Degradation by the ubiquitin proteasome pathway controls level of the transgenic protein. Mol. Cell. Biol. 25:5270-5281, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15923640) Exit NIEHS
  19. Gaussin, V., Morley, G. E., Cox, L., Zwijsen, A., Vance, K. M., Emile, L., Tian, Y., Liu, J., Hong, C., Myers, D., Conway, S. J., Depre, C., Mishina, Y, Behringer, R. R., Hanks, M. C., Schneider, M. D., Huylebroeck, D., Fishman, G. I., Burch, J. B., and Vatner, S., F.: Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus.  Circulation Res. 97:219-226, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16037571) Exit NIEHS
  20. Kishigami, S., Komatsu, Y., Takeda, H., Nomura-Kitabayashi, A., Yamauchi, Y., Abe, K., Yamamura, K., and Mishina, Y.: Optimized beta-galactosidase staining method for simultaneous detection of endogenous gene expression in early mouse embryos.  Genesis 44:57-65, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16419090) Exit NIEHS
  21. Eblaghie, M. C., Reedy, M., Oliver, T., Mishina, Y., and Hogan, B. L. M. Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells.  Dev. Biol. 291:67-82, 2006. (Published online January 18, 2006) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16414041) Exit NIEHS
  22. Fukuda, T., Komatsu, Y., Scott, G., Araya, R., Kawano, M., Ray, M. R., Yamada, M., and Mishina, Y.: Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2. Genesis  44:159-167, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16604518) Exit NIEHS
  23. Israelsson, C., Lewén, A., Kylberg, A., Usoskin, D., Althini, S., Lindeberg, J., Deng, C-X., Fukuda, T., Wang, Y., Kaartinen, V., Mishina, Y., Hillered, L., and Ebendal, T. : Genetically modified Bone Morphogenetic Protein signalling alters traumatic brain injury-induced gene expression responses in the adult mouse.  J. Neruosci. Res. 84:47-57, 2006. (Published online March 31, 2006). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16583403) Exit NIEHS
  24. Ovchinnikov, D. A., Selever, J., Wang, Y., Chen, Y. T., Mishina, Y., Martin, J. F., Behringer, R.R.: BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning.  Dev. Biol. 295:103-115, 2006. (Published online Apr. 19, 2006) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16630606) Exit NIEHS
  25. Park, C., Mishina, Y., Lavine, K., Deng, C-X., Ornitz, D. M., and Choi K. Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development. 133:3473-3484, 2006. (Published online Aug. 3, 2006) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16887829) Exit NIEHS
  26. Miura, S., Davis, S., Klingensmith, J. and Mishina, Y.: BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development. 133:3767-3775, 2006. (Published online Aug. 30, 2006) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16943278) Exit NIEHS
  27. Baek, S. J., Okazaki, R., Martinez, J., Kim, J.-S., Lee, S.-H., Yamaguchi, K., Mishina, Y., Martin, W. D., Shoieb,A., McEntee, M. F., and Eling, T. E.: Nonsteroidal anti-inflammatory drug activated gene-1 over-expression in transgenic mice suppresses intestinal neoplasia. Gastroenterology.  131:1553-1560, 2006. (Published online Sep. 19, 2006) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17101328) Exit NIEHS
  28. Song, L., Faessler, R., Mishina, Y., Kai, J., Baldwin, H. S.: Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts. Dev. Biol. 301: 276-286, 2007. (Published online Aug. 9, 2006). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16959237) Exit NIEHS
  29. Zhang, J., He, X. C., Tong., W. G., Johnson, T., Wiedemann, L. M., Mishina, Y., Feng, J. Q., and Li, L.: Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion. Stem Cells 24:2826-2839, 2006. (Published online Sep. 7, 2006). [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16960130) Exit NIEHS
  30. Yoon, B. S., Pogue, R., Ovchinnikiv, D. A., Yoshii, I., Mishina, Y., Behringer, R. R., and Lyons, K. M.: BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways.  Development. 133:4667-4778, 2006. (Published online Oct. 25, 2006) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17065231) Exit NIEHS
  31. Komatsu, Y., Scott, G., Nagy, A., Kaartinen, V., and Mishina, Y.: BMP type I receptor ALK2 is essential for proper mesoderm patterning at late gastrulation during mouse embryogenesis. Dev. Dyn.236: 512-517, 2007. (Published online Nov. 20, 2006) [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17117439) Exit NIEHS
  32. Feng JQ, Scott G, Guo D, Jiang B, Harris M, Ward T, Ray M, Bonewald LF, Harris SE, Mishina Y. Generation of a conditional null allele for Dmp1 in mouse. Genesis (New York, N.Y. : 2000) 46(2):87-91, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18257058) Exit NIEHS
  33. Araya, R., Kudo, M., Kawano, M., Ishii, K., Hashikawa, T., Iwasato, T., Itohara, S., Terasaki, T., Oohira, A., Mishina, Y., and Yamada, M.: BMP signaling through BMPRIA in astroglia is essential for proper cerebral angiogenesis and formation of the blood-brain barrier. Nature neuroscience 38:417-430, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18501628) Exit NIEHS
  34. Singh, A.P., Castranio, T., Scott, G., Guo, D., Harris, M.A., Ray, M., Harris, S., Mishina, Y.: Influences of reduced expression of maternal bone morphogenetic protein 2 on embryonic development. Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2:134-141, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18769073 ) Exit NIEHS
  35. Inagaki M, Komatsu Y, Scott G, Yamada G, Ray M, Ninomiya-Tsuji J, Mishina Y. Generation of a conditional null allele for Tab1 in mouse. Genesis (New York, N.Y. : 2000) 46(8):431-439, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18693278) Exit NIEHS
  36. O'Bryan MK, Takada S, Kenneday CL, Scott G, Harada S, Ray MK, Dai Q, Wilhelm D, Kretser D, Eddy EM, Koopman P, Mishina Y. Sox8 is a critical regulator of adult Sertoli cell function and male fertility. Developmental biology 316(2):359-370, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18342849) Exit NIEHS
  37. Castranio T, Mishina Y. BMP2 is required for cephalic neural tube closure in the mouse. Development (Cambridge, England) 238(1):110-122, 2009. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19097048) Exit NIEHS

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Last Reviewed: January 14, 2009