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Research
Updated: 11/20/08


Funding Opportunities - Active Program Announcements

Program Announcements:

The Bernard Osher Foundation/NCCAM CAM Practitioner Research Career Development Award (K01)
PAR-07-003
Release Date: 10/5/2006
Expiration Date: 1/3/2010
The specific purpose of this research career development Award (K01) is to provide research training support for CAM Practitioners with clinical doctorates, who have had limited opportunities for research training, but a strong desire to pursue a career in CAM research. The long term goal is to encourage more CAM practitioners to enter research careers, thus enriching CAM research through their experience and knowledge of CAM practice. This award will provide support and “protected” time (three, four, or five years) for intensive, supervised career development research experience in the biomedical, behavioral, or clinical sciences related to CAM.

Exploratory/Developmental Grant for Complementary and Alternative Medicine (CAM) Studies of Humans (R21)
PAR-08-135
Release Date: 4/3/2008
Expiration Date: 5/8/2011
The primary purpose of this Funding Opportunity Announcement (FOA), issued by the National Center for Complementary and Alternative Medicine (NCCAM), the National Cancer Institute (NCI), the National Institute on Aging (NIA), and the Office of Dietary Supplements (ODS), National Institutes of Health (NIH), is to encourage the submission of high quality, preliminary research of humans that will advance the science of CAM.  Such studies will ultimately provide a solid foundation and justification for larger, subsequent clinical studies to determine definitively the efficacy and effectiveness of complementary and alternative medicine (CAM) approaches.

Exploratory/Developmental Grant for Complementary and Alternative Medicine (CAM) Studies using Cells, Tissues, and Animal Models of Disease (R21)
PA-08-185
Release Date: 6/26/2008
Expiration Date: 9/8/2011
This announcement invites applications for funding of basic, mechanistic, and/or preclinical research in all domains of CAM, in order to elucidate the underlying mechanisms of action of CAM therapies and to provide a stronger foundation for ongoing and planned clinical studies. This funding opportunity announcement (FOA) is for basic, mechanistic, and/or preclinical research using cells, cell lines, tissues, cadavers, and animal model systems.

Basic and Preclinical Research on Complementary and Alternative Medicine (R01)
PA-09-010
Release Date: 10/20/2008
Expiration Date: 1/8/2012
This announcement encourages complementary and alternative medicine (CAM) and conventional researchers to carry out basic and/or preclinical research on CAM areas of special interest with an aim to understand the mechanisms of action of a CAM modality. NCI solicits applications on basic, mechanistic, and preclinical research as it relates to the prevention, diagnosis, and treatment of cancer as well as management of cancer symptoms and side effects due to conventional cancer treatment. Areas of interest include interactions between conventional cancer treatment and CAM modalities.

Diet, Epigenetic Events, and Cancer Prevention (R01)
PA-07-175
Release Date: 12/15/2006
Expiration Date: 9/2/2009
The aim of this funding opportunity announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. This FOA will use the NIH research project grant (R01) award mechanism.

Pathogenesis and Treatment of Lymphedema and Lymphatic Diseases (R01)
PA-07-165
Release Date: 12/14/06
Expiration Date: 12/31/09
The purpose of this program announcement is to stimulate research on the biology of the lymphatic system, to characterize at the molecular, cellular, tissue, organ, and intact organism levels, the pathophysiologic mechanisms that cause the disease, to develop new methods for quantitating and imaging lymph flow, to discover new therapeutic interventions, and to determine the safety, efficacy and mechanisms of action of complementary and alternative therapies.

Prioritizing Molecular Targets for Cancer Prevention with Nutritional Combinations (R01)
PA-07-100
Release Date: 12/1/2006
Expiration Date: 11/2/2009
This announcement solicits innovative research project (R01) grant applications to enhance mechanistic understanding of the dynamic interrelationship between bioactive food components and/or food combinations and cancer prevention. Projects must focus on either multiple dietary bioactive components, intact foods, and/or multiple foods utilizing physiologically relevant concentrations of the bioactive agents.

Mechanisms, Models, Measurement, & Management in Pain Research (R21)
PA-06-542
Release Date: 8/30/2006
Expiration Date: 9/2/2009
This announcement utilizes the R21 grant mechanism. New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences. The purpose of this funding announcement is to inform the scientific community of the pain research interests of the various Institutes and Centers (ICs) at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic, clinical, and translational studies on pain as they relate to the missions of these ICs.

Mechanisms, Models, Measurement, & Management in Pain Research (R03)
PA-06-543
Release Date: 8/30/2006
Expiration Date: 9/2/2009
This announcement utilizes the R03 grant mechanism. New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences. The purpose of this funding announcement is to inform the scientific community of the pain research interests of the various Institutes and Centers (ICs) at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic, clinical, and translational studies on pain as they relate to the missions of these ICs.

Mechanisms, Models, Measurement, & Management in Pain Research (R01)
PA-07-282
Release Date: 1/8/2007
Expiration Date: 9/2/2009
This announcement utilizes the R01 grant mechanism. New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences. The purpose of this funding announcement is to inform the scientific community of the pain research interests of the various Institutes and Centers (ICs) at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic, clinical, and translational studies on pain as they relate to the missions of these ICs.

Diet, Epigenetic Events, and Cancer Prevention (R21)
PA-06-413
Release Date: 5/16/2006
Expiration Date: 9/2/2009
The aim of this funding opportunity announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. This FOA utilizes the NIH exploratory/developmental (R21) grant mechanism.

Diet, Epigenetic Events, and Cancer Prevention (R03)
PA-06-414
Release Date: 5/16/2006
Expiration Date: 9/2/2009
The aim of this funding opportunity announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. This FOA will use the NIH research project grant (R03) award mechanism.

Studies of Energy Balance and Cancer in Humans (R01)
PA-07-176
Release Date: 12/15/2006
Expiration Date: 5/8/2009
The National Cancer Institute (NCI) invites investigator-initiated research applications on energy balance in humans. These studies will focus on research to define factors affecting energy balance and to define mechanisms influencing cancer risk, prognosis, and quality of life. These studies may range from new analyses of existing datasets to additional collection of data and biological specimens in ongoing investigations. It is anticipated that the knowledge gained will provide additional information to better understand the relationships among energy balance, cancer risk, and cancer prognosis. Competitive supplement applications to existing NCI-funded grants as well as new R01 applications are invited.

Studies of Energy Balance and Cancer in Humans (R21)
PA-06-405
Release Date: 5/9/2006
Expiration Date: 5/9/2009
The National Cancer Institute (NCI) invites investigator-initiated research applications on energy balance in humans. These studies will focus on research to define factors affecting energy balance and to define mechanisms influencing cancer risk, prognosis, and quality of life. These studies may range from new analyses of existing datasets to additional collection of data and biological specimens in ongoing investigations. It is anticipated that the knowledge gained will provide additional information to better understand the relationships among energy balance, cancer risk, and cancer prognosis. Competitive supplement applications to existing NCI-funded grants as well as new R01 applications are invited. This FOA utilizes the NIH exploratory/developmental (R21) grant mechanism.

Exploratory Grants for Behavioral Research in Cancer Control (R21)
PA-06-351
Release Date: 04/12/2006
Expiration Date: 05/2/2009
NCI invites the submission of behavioral research applications in cancer control from investigators from a wide range of behavioral and social science disciplines who wish to focus their research on the behavioral aspects of the cancer control continuum from prevention to end of life care.

Diet-Induced Changes in Inflammation as Determinants of Colon Cancer (R21)
PA-08-211
Release Date: 7/18/2008
Expiration Date: 9/8/2011
This funding opportunity announcement (FOA) encourages the submission of grant applications that describe research projects focused on the identification and characterization of diet-induced changes in inflammation linked to colon cancer risks.  This FOA is designed to stimulate research efforts  that will lead to the identification and characterization of: a) diet-induced changes in anti- and pro-inflammatory mediators that modulate colon cancer risk; b) genetic polymorphisms that modify the responses to specific bioactive food components with regard to colon cancer inhibition; and c) the physiological effectiveness of dietary components in terms of concentration, activity, duration of exposure, degrees of stability, chemical forms, and receptor-binding affinity in inflammatory colonocytes.  This FOA will not support applications that propose epidemiological studies based on diet-related risks of colon cancer.

Quick-Trials for Novel Cancer Therapies and Prevention: Exploratory Grants (R21)
PAR-08-025
Release Date: 11/19/07
Expiration Date: 11/10/2010
This FOA is intended to promote translational research in new agent/modality development with timely exploitation of new cancer-relevant therapeutic and/or preventive strategies that involve defined molecular targets.  Applications are solicited for pilot clinical trials exploring individual anticancer agents/modalities and/or their combinations in the context of specific molecular targets.  Applicants may propose Phase 0, Phase I, Phase II, and/or other pilot cancer clinical trials.  In addition, patient monitoring and laboratory correlative studies related to clinical trials may be proposed.  Applications that explore complementary and alternative approaches for cancer prevention and/or treatment are also encouraged.  Clinical trials proposed may be oriented on AIDS-associated malignancies and cancer-related nutritional interventions. 

Methodology and Measurement in the Behavioral and Social Sciences (R01)
PAR -08-212
Release Date: 7/22/2008
Expiration Date: 9/8/2011
This initiative encourages applications addressing four general areas of methodology and measurement research in the social and behavioral sciences. The areas are research design, data collection techniques, measurement, and data analysis.

Methodology and Measurement in the Behavioral and Social Sciences (R03)
PAR-08-214
Release Date: 7/22/2008
Expiration Date: 9/8/2011
This initiative encourages applications addressing four general areas of methodology and measurement research in the social and behavioral sciences. The areas are research design, data collection techniques, measurement, and data analysis.

Methodology and Measurement in the Behavioral and Social Sciences (R21)
PAR-08-213
Release Date: 7/22/2008
Expiration Date: 9/8/2011
This initiative encourages applications addressing four general areas of methodology and measurement research in the social and behavioral sciences. The areas are research design, data collection techniques, measurement, and data analysis.

Developmental Projects in Complementary Approaches to Cancer Care (R21)
PA-06-400
Release Date: 05/9/2006
Expiration Date: 02/2/2009
NIH invites research grant applications from interested investigators to conduct innovative developmental pilot research investigating complementary approaches in cancer. The intent of this initiative is to encourage and support the development of basic and clinical complementary cancer research and to provide the basis for more extended research projects.

Clinical Cancer Therapy and Prevention Research (R01)
PA-07-356
Release Date: 04/16/2007
Expiration Date: 05/8/2010
The NCI is seeking R01 applications to conduct translational, clinical, therapeutic, and preventive studies/trials of neoplastic diseases in humans and encourages clinical researchers to collaborate with basic scientists to translate insights in cancer biology and the development of new anti-cancer agents into innovative cancer intervention studies/trials. The overall aims of this funding opportunity announcement are two-fold: (1) to stimulate the development of innovative cancer prevention and therapy clinical trials with or without laboratory correlative studies; and (2) to support innovative correlative laboratory studies retrospectively and prospectively linked to therapeutic/preventive clinical trials.


Research on Mind-Body Interactions and Health (R01)
PA-07-046
Release Date: 11/21/2006
Expiration Date: 01/3/2010
The purpose of this announcment is to invite applications in support of research on mind-body interactions and health. "Mind-body interactions and health" refers to the relationships among cognitions, emotions, personality, social relationships, and health. A central goal of this program is to encourage interdisciplinary collaboration and innovation towards understanding the processes underlying mind-body interactions and health as well as towards the application of such basic knowledge to interventions and clinical practice in the promotion of health and the prevention or treatment of disease and disabilities.

Outcomes, Cost-Effectiveness and the Decision Making Process to Use Complementary and Alternative Medicine (R01)
PAR-08-045
Release Date: 12/12/2007
Expiration Date: 5/20/2010
The primary purpose of this Funding Opportunity Announcement (FOA), is to encourage the submission of high quality observational studies evaluating the effectiveness and cost-effectiveness of complementary and alternative medicine (CAM) approaches as used in the community, and the decision processes employed by patients and providers in deciding to use CAM. 

Symptom Interactions in Cancer and Immune Disorders (R01)
PA-08-121
Release Date: 3/28/2008
Expiration Date: 5/8/2011
The primary purpose of this Funding Opportunity Announcement (FOA) is to solicit grant applications from applicant organizations that propose to (a) identify and assess biobehavioral interactions among two or more related and co-occurring symptoms; (b) characterize mechanisms and pathways underlying the symptom interactions; (c) elucidate the level of interaction necessary for categorization as a symptom cluster; and/or (d) design and test interventions targeted to interacting or clustered symptoms that are hypothesized to lead to beneficial patient outcomes

Omics and Variable Responses to CAM: Secondary Analysis of CAM Clinical Trials (R01)
PAR-07-377
Release Date: 6/6/2007
Expiration Date: 8/15/2009
This Funding Opportunity Announcement (FOA) encourages examination of differences in genomics, proteomics, and metabolomics and other omics that may be responsible for variations in individual responses to complementary and alternative medicine (CAM) (NCCAM) or bioactive food component (NCI) interventions using samples obtained from ongoing and completed clinical studies.

Omics and Variable Responses to CAM: Secondary Analysis of CAM Clinical Trials (R21)
PAR-07-378
Release Date: 6/6/2007
Expiration Date: 8/15/2009
This Funding Opportunity Announcement (FOA) encourages examination of differences in genomics, proteomics, and metabolomics and other omics that may be responsible for variations in individual responses to complementary and alternative medicine (CAM) (NCCAM) or bioactive food component (NCI) interventions using samples obtained from ongoing and completed clinical studies.

Diet Composition and Energy Balance (R01)
PAR-07-218
Release Date: 2/14/2007
Expiration Date: 3/6/2010
The goal of this funding opportunity announcement (FOA) is to invite Research Project Grant (R01) applications investigating the role of diet composition in energy balance, including studies in both animals and humans.  Both short and longer-term studies are encouraged, ranging from basic studies investigating the impact of micro-or macronutrient composition on appetite, metabolism, and energy expenditure through clinical studies evaluating the efficacy of diets differing in micro- or macronutrient composition, absorption, dietary variety, or energy density for weight loss or weight maintenance.