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Michelle J. Hooth, Ph.D.

Toxicology Branch

Michelle J. Hooth, Ph.D.
Michelle J. Hooth, Ph.D.

Tel (919) 316-4643
Fax (919) 541-4255
P.O. Box 12233
Mail Drop EC-35
Research Triangle Park, North Carolina 27709
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Michelle Hooth, Ph.D., is a toxicologist in the Toxicology Branch. Her primary responsibilities include designing animal studies to evaluate the toxicity and carcinogenicity of chemicals selected by the National Toxicology Program and the evaluation and interpretation of toxicity and carcinogenicity data for publication as NTP technical reports and papers in scientific journals. Hooth manages several chemicals including compounds that are used in consumer products and food, as chemical intermediates and that occur as environmental contaminants. She has a particular interest in drinking water contaminants.

Hooth received a B.S. in biological sciences from Michigan State University, East Lansing, Michigan and a Ph.D. in toxicology from the University of North Carolina at Chapel Hill. She completed postdoctoral work at the National Health and Environmental Effects Research Laboratory, U. S. Environmental Protection Agency, Research Triangle Park, North Carolina.

Selected Publications

  1. McDorman KS, Chandra S, Hooth MJ, Hester SD, Schoonhoven R, Wolf DC. Induction of transitional cell hyperplasia in the urinary bladder and aberrant crypt foci in the colon of rats treated with individual and a mixture of drinking water disinfection by-products. Toxicol Pathol. 2003 Mar-Apr;31(2):235-42. [Abstract] ( Exit NIEHS
  2. McDorman KS, Hooth MJ, Starr TB, Wolf DC. Analysis of preneoplastic and neoplastic renal lesions in Tsc2 mutant Long-Evans (Eker) rats following exposure to a mixture of drinking water disinfection by-products. Toxicology. 2003 May 1;187(1):1-12. [Abstract] ( Exit NIEHS
  3. Hooth MJ, McDorman KS, Hester SD, George MH, Brooks LR, Swank AE, Wolf DC. The carcinogenic response of Tsc2 mutant Long-Evans (Eker) rats to a mixture of drinking water disinfection by-products was less than additive. Toxicol Sci. 2002 Oct;69(2):322-31. [Abstract] ( Exit NIEHS
  4. Shiao YH, Kamata SI, Li LM, Hooth MJ, DeAngelo AB, Anderson LM, Wolf DC. Mutations in the VHL gene from potassium bromate-induced rat clear cell renal tumors. Cancer Lett. 2002 Dec 10;187(1-2):207-14. [Abstract] ( Exit NIEHS
  5. Hooth, M.J., DeAngelo, A.B., George, M.H., Wolf, D.C, and Boorman, G.A. Sodium chlorate treatment results in a dose-dependent increase in rat thyroid follicular cell hyperplasia after subchronic exposure in drinking water. In : Microbial Pathogens and Disinfection By-Products in Drinking Water: Health Effects and Management of Risks. Craun, G.F., Hauchman, F.S., and Robinson, D.E. (eds.) ILSI Press, Washington, DC p. 581-585, 2001.
  6. Hooth MJ, Deangelo AB, George MH, Gaillard ET, Travlos GS, Boorman GA, Wolf DC. Subchronic sodium chlorate exposure in drinking water results in a concentration-dependent increase in rat thyroid follicular cell hyperplasia. Toxicol Pathol. 2001 Mar-Apr;29(2):250-9. [Abstract] ( Exit NIEHS
  7. Golubovskaya VM, Filatov LV, Behe CI, Presnell SC, Hooth MJ, Smith GJ, Kaufmann WK. Telomere shortening, telomerase expression, and chromosome instability in rat hepatic epithelial stem-like cells. Mol Carcinog. 1999 Mar;24(3):209-17. [Abstract] ( Exit NIEHS
  8. Hooth, M.J., Coleman, W.B., Presnell, S.C., Borchert, K.M., Grisham, J.W., and Smith, G.J. Spontaneous neoplastic transformation of WB-F344 rat liver epithelial cells. The American Journal of Pathology, 153:1913-1921, 1998. [Abstract] ( Exit NIEHS
  9. Presnell, S.C., Hooth, M.J., Borchert, K.M., Coleman, W.B., Grisham, J.W., and Smith, G.J. Establishment of a functional hepatocyte growth factor/c-met autocrine loop in spontaneous transformants of WB-F344 rat liver stem-like cells. Hepatology, 28:1253-1259, 1998. [Abstract] ( Exit NIEHS
  10. Hooth, M.J., Vincent, J.L., Coleman, W.B., Presnell, S.C., Grisham, J.W., and Smith, G.J. Genomic fluidity is a necessary event preceding the acquisition of tumorigenicity during spontaneous neoplastic transformation of WB-F344 rat liver epithelial cells. Hepatology, 28:78-85, 1998. [Abstract] ( Exit NIEHS
  11. Golubovskaya, V.M., Presnell, S.C., Hooth, M.J., Smith, G.J., and Kaufmann, W.K. Expression of telomerase in normal and malignant rat hepatic epithelia. Oncogene 14: 1233-1240, 1997. [Abstract] ( Exit NIEHS

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