The FY 2003 Appropriation for NIA (including AIDS) is $993,598,000 (post rescission) an increase of 11.1 percent over the FY 2002 actual amount of $891,302,000. Funding for AIDS related research increases from $4,985,000 in FY 2002 to $5,344,000 in FY 2003 an increase of 7.2 percent.
The FY 2003 Appropriation for NIH (including AIDS) increases from $23,478,083,000 in FY 2002 to $27,171,000,000 in FY 2003, an increase of 15.7 percent.
One of NIH’s highest priorities is the funding of medical research through research project grants (RPGs). Support for RPGs allows NIH to sustain the scientific momentum of investigator-initiated research while providing new research opportunities. The FY 2003 NIA appropriation provides an average cost increase for competing RPGs at 4.0 percent.
Promises for advancement in medical research are dependent on a continuing supply of new investigators with new ideas. With the FY 2003 Appropriation, NIA will support 571 pre- and post-doctoral trainees in full-time training positions, the same number as in FY 2002.
The FY 2003 appropriation includes funding for 1,458 research project grants, compared to 1,315 in FY 2002. Of these 1,458 awards, 480 will be competing research project grants and 978 will be noncompeting awards. In addition, the appropriation includes funding for 73 SBIR/STTR grants.
Funding for the Centers mechanism increases by 5.2 percent over the FY 2002 level.
The FY 2003 Appropriation includes an increase of 4.5 percent over FY 2002 for Other Research.
Funding for Contracts in FY 2003 increases by 27 percent over FY 2002 due to the large Program Evaluation assessment in FY 2003.
The FY 2003 Appropriation includes an 11 percent increase above FY 2002 for Intramural Research and a 10 percent increase above FY 2002 for Research, Management, and Support (RMS).
(Contact: Mr. Kevin Laser, BO, Ph: 301.496.9147)
In Sec.3(f), NIH is directed to:
Four New Members Named to the NACA: Four new members were appointed to the National Advisory Council on Aging (NACA)
Dallas W. Anderson, Ph.D., joined the Dementias of Aging Branch, NNA, on June 1. Dr. Anderson serves as the program director for population studies of Alzheimer's disease and other age-related dementias. Previously, he was senior investigator and head of the Population Studies Unit, Division of Intramural Research, National Institute of Neurological Disorders and Stroke (NINDS).
Dr. Sidney Stahl, a Health Scientist Administrator in the Individual Behavioral Processes Branch (IBP), Behavioral and Social Research (BSR) Program, has been selected as the new Chief for that Branch. Dr. Stahl joined NIA's Behavioral and Social Research Program almost seven years ago, having served for many years as a professor of sociology at Purdue University. Dr. Stahl will continue to have responsibility for the Behavioral Medicine and Interventions section of the IBP Branch. That section's research contains NIA's Resource Centers for Minority Aging Research (RCMARs), informal and formal caregiving research including NIA's Alzheimer's disease caregiving portfolio, long-term care research, elder mistreatment, and end-of-life research among other central NIA research commitments.
The BSR Program welcomed Dr. Jeffrey Elias as a Health Scientist Administrator to its Individual and Behavioral Processes Branch on May 19. Dr. Elias, a psychologist with interdisciplinary interests, is directing BSR's section on Cognitive Aging. He is also actively involved in BSR's efforts to apply an integrative approach to the study of health, behavior, stress and coping, and well-being over the life course.
After 27 years on the faculty at Texas Tech and the University of Nevada, Dr. Elias joined NIH in July 2001 as the Scientific Review Administrator of the Adult Psychopathology and Aging Disorders review section in the Center for Scientific Review. Dr. Elias has conducted research in aging that spans the areas of developmental psychobiology, cognitive psychology, and neuropsychology. Dr. Elias was elected to Fellow status in the Gerontological Society of America, the American Psychological Association, and the American Psychological Society. He currently serves as the Editor-in-Chief of the journal Experimental Aging Research.
Dr. Julia Lane, an economist, joined the BSR Program, in the Population and Social Processes Branch on April 14. Dr. Lane is working with BSR on a part-time basis under the Intergovernmental Personnel Act (IPA) Mobility Program, which provides for the temporary assignment of personnel between the Federal Government and state and local governments, colleges and universities, Indian tribal governments, federally funded research and development centers, and other eligible organizations. Under the IPA, Dr. Lane is working on developing options for a focused BSR research agenda in Health Services Research. Dr. Lane is a Senior Research Fellow at the Census Bureau and Director of the Employment Dynamics Program at the Urban Institute. She has been working with wage record data for over a decade and with the Local Employment Dynamics Program at the U.S. Census Bureau for five years. She has published over 40 articles, and co-edited two books. She (together with John Abowd and John Haltiwanger) has received major grants from the National Science Foundation, the Alfred P. Sloan Foundation, the Rockefeller Foundation, the Russell Sage Foundation, as well as many government agencies. She has been a keynote speaker at a number of international conferences - most recently at the Conference of European Statisticians in Geneva.
Stanley Slater, M.D., of the Geriatrics and Clinical Gerontology Program's Geriatrics Branch, retired from the Public Health Service on August 1. Dr. Slater had been with NIA for 15 years, and was responsible for several areas of clinical research. He played a notable role in the development of the Pepper Centers program, and in the initiation of intervention studies of hormonal replacement in older persons. Prior to arriving at NIA, Dr. Slater served with NICHD and NCRR, where he made contributions to their Centers programs. He also collaborated with Dr. Trey Sunderland in intramural research on pharmacotherapy for Alzheimer's disease.
Dr. Charles Hollingsworth, who was Chief of the Geriatrics and Clinical Gerontology Program's Clinical Trial Branch, left NIA in August to become Scientific Review Administrator of the new Aging Systems and Geriatrics Study Section in the NIH Center for Scientific Review. Before coming to NIA in 2002, Dr. Hollingsworth had served in the scientific review branch at the National Center for Research Resources for several years.
Dr. Kathleen Koepke, who was a Social Science Analyst with the Individual and Behavioral Processes Branch in BSR, transferred to a new position as a Health Scientist Administrator at the National Institute on Nursing Research on July 14.
Ms. Lisa Vasquez, a Program Analyst, transferred to the Substance Abuse and Mental Health Administration for a mental health policy-oriented/program evaluation position.
Satellite Workshop on Immunology and Aging. An NIA-sponsored satellite workshop (exploratory) was conducted on May 7 during the annual American Association of Immunology (AAI) meeting in Denver, Colorado. The purpose of the workshop was to allow attendees at the national meeting the opportunity to become familiar with recent progress in research on aging-related defects in immunity and to allow an opportunity for researchers working in different areas of immunology to interact. Three speakers presented overviews of the current state of research into age-related defects in lymphopoiesis, T cell compartments, and B cell compartments, followed by a presentation by NIA program staff highlighting NIA interests and current funding opportunities. (Contact: Dr. Rebecca Fuldner, BAP, Ph: 301-496-6402)
Hutchinson-Gilford Progeria Syndrome Workshop. The Biology of Aging Program co-sponsored an advisory workshop on Hutchinson-Gilford Progeria syndrome (HGPS) with the National Human Genome Research Institute (NHGRI), the Office of Rare Diseases, and the Progeria Research Foundation on July 28-29, 2003. The workshop included four sessions: (1) Clinical and genetic aspects of HGPS, (2) Aging and the biochemistry of lamin A, (3) Molecular biology and physiology of HGPS, and (4) Treatment strategies for HGPS. The participants first discussed the genetic basis of HGPS and other laminopathies (mutations in the lamin A gene), and then discussed how the HGPS phenotypes might be informative about normal aging phenotypes. Of particular interest was the final session discussing possible therapeutic strategies for treating this syndrome; included in this discussion were presentations on stem cell therapy, gene therapy, leptin supplementation, manipulation of the processing of mutant pre-lamin A protein, use of interfering RNA, and random drug screening. By analogy with earlier work on osteogenesis imperfecta, the stem cell approach appears particularly promising. Transgenic mouse and transfected cell models of the various laminopathies are expected to be extremely useful for testing the above strategies, and for learning more about the molecular basis for development of adverse aging-related phenotypes in humans. (Contact: Dr. Huber Warner, BAP, Ph: 301-496-4996)
Genetics of Late Onset Alzheimer's Disease Case Control. An advisory workshop on the Genetics of Late Onset Alzheimer's Disease (LOAD) Case Control was held on May 5. The workshop was convened to determine the goals, study design, and inclusion/exclusion criteria for cases and controls for a national case-control study for the genetics of LOAD. Participants included Alzheimer's disease (AD) geneticists, genetic epidemiologists, epidemiologists, and NIH/DHHS staff from five institutes. Substantive interactions occurred during an open discussion of all participants on key issues. The workshop participants generated a set of suggestions for further research on the genetics of late onset AD. Participants concurred that the sample set could be comprised, in part, of a subset of representative cases already participating in the family-based sample series. It was recommended that controls could be provided by Alzheimer Disease Centers (ADCs) and could also be supplemented from existing epidemiology studies. A major consideration was the possible use of samples from properly informed and consented individuals already participating in other NIH funded studies. A minority sample could be collected from a subset of ADCs and/or epidemiology studies. (Contact: Dr. Marilyn M. Miller, NNA, Ph: 301-496-9350)
Workshop on Executive Functions. A trans-NIH workshop (advisory) on Executive Functions was held on June 15-17, 2003, in New York as a Satellite Meeting of the Organization for Human Brain Mapping 2003 Meeting. This workshop was co-sponsored by NINDS, NIMH, NIDA, NIAAA and the NIA Neuroscience and Neuropsychology of Aging Program as a follow-up on the NIA Workshop on Executive Functions held in January 2003. The goal of the June workshop was to bring together leaders of the larger cognitive neuroscience field to discuss new perspectives, research findings, and controversies in executive function; assess the state of knowledge regarding executive function in the healthy and injured/diseased states; and set a research agenda for future studies of executive function. The proceedings of the workshop will be published in a peer-review journal. Recommendations from the meeting on how to promote multi-disciplinary research in issues central to the study of executive function in neurological, mental, drug abuse, alcohol abuse and age related disorders are being prepared. (Contact: Dr. Elisabeth Koss, NNA, Ph: 301-496-9350)
Longitudinal Data on Aging (LDA) Working Group. The Geriatrics and Clinical Gerontology (GCG) Program convened the first exploratory meeting of the Longitudinal Data on Aging (LDA) Working Group, on July 28-29. The LDA working group consisted of epidemiologists, biostatisticians, basic researchers, and other scientists with relevant expertise and an interest in increasing knowledge about changes across the lifespan that affect health and functional status in old age. The presentations and discussions at the meeting focused on strategies to address these issues through analyses of existing longitudinal data sets, expansion or extension of existing studies, and/or development of new studies. Specific topics discussed at this meeting included (1) pathologic significance of aging changes from youth onwards, (2) exceptionally healthy aging, (3) variability in rates of aging changes and (4) opportunities for translation of insights from basic aging research on this issues, into clinical aging research. GCG envisions that the LDA Working Group will meet several times over the next few years. Information from these meetings could be used by members of the LDA Working Group in considering opportunities for additional research projects in their own study populations or collaborations with other studies, and by NIA in considering topics for new program initiatives and research project solicitations. (Contact: Dr. Chhanda Dutta, GCG, Ph: 301-496-6761)
Workshop on Cognitive/Brain Reserve and Aging. The Neuroscience and Neuropsychology of Aging Program (NNA) sponsored an exploratory workshop on August 26-27 on the concepts and research pertaining to cognitive and brain reserve. It has been repeatedly noted that there is no clear direct relationship between the degree of brain pathology and the clinical manifestations of a variety of central nervous system (CNS) insults, such as in stroke and Alzheimer's disease. The concept of a brain or cognitive reserve is being invoked to address these effects. A marker of brain reserve is the amount of damage that can be sustained before a threshold is reached for clinical expression, and reflects the physical properties of the brain such as brain size, synapse count, dendritic interactions, etc. Cognitive reserve refers to brain networks or cognitive functions that are less susceptible to disruption, and reflects the ability to sustain disruption and operate effectively, such as through the use of alternative networks or cognitive paradigms. The objectives of the workshop were to determine definitions of reserve, elucidate underlying mechanisms, develop potential human and animal studies, and formulate strategies for enhancing reserves. (Contacts: Drs. Andrew Monjan and Molly Wagster, NNA, Ph: 301-496-9350)
Innate Immunity and Aging. An NIA-sponsored satellite (exploratory) symposium on Innate Immunity and Aging is planned for October 2 to be held during the annual Society for Leukocyte Biology meeting in Philadelphia. The purpose of this meeting is to allow attendees at the national meeting the opportunity to become familiar with recent progress in research on age-associated changes in the innate immune system and to allow an opportunity for researchers working in this field to interact. The program will consist of six presentations followed by a poster session. In addition, the symposium will include a presentation by NIA program staff highlighting NIA interests and current funding opportunities. (Contact: Dr. Rebecca Fuldner, BAP, Ph: 301-496-6402)
Task Force on Comorbidity Research Issues. The Geriatrics and Clinical Gerontology (GCG) Program will convene the first exploratory meeting of an interdisciplinary Task Force on Comorbidity Research Issues in older persons on October 21-23. The NIA Task Force will bring together experts in geriatrics, other clinical specialties and health professions, pharmacology, epidemiology, pathophysiology, physical functioning, gerontology, and other disciplines to discuss specific knowledge gaps and methods that may be developed to improve evaluation of the older patient newly diagnosed with a major illness. The group will confer about ways to enhance the accuracy and improve prediction of the effectiveness of therapy of older persons in the presence of comorbid conditions that may compromise the patient. Major questions will include: How does the already health-compromised older person tolerate the additional physical and physiological stress of a major disease (e.g., heart disease, cancer, diabetes, and treatment for these conditions alone or in combination)? How do these age-related conditions interact and influence the treatment course and recovery of the index disease or health problem? The charge to the Task Force will be to identify specific important unanswered clinical questions and suggest research strategies on an array of health issues. The information generated in the Task Force will provide the foundation for new program initiatives. (Contact: Dr. Rosemary Yancik, GCG, Ph: 301-496-6761)
NIA Training of the Aging Mind Exploratory Meeting. The NIA Training of the Aging Mind exploratory meeting will be held in January 2004. The meeting will be attended by BSR-supported grantees who are studying training processes. The goal of the meeting is to develop an advisory document on this topic. There is a high degree of public and scientific interest in cognitive training for older adults. The concept of training and cognitive processes of aging would benefit from reliable information. This emphasis is particularly important within the context of the aging worker, advances in technology, and use of non-work time. NIA/BSR seeks to lead the effort to provide authoritative and scientifically based information and to maximize benefit from BSR's portfolio of funded research on the use of training to benefit cognitive processes of the elderly. A teleconference in September will map out topics for discussion and the variety of approaches to training that will be represented in the January 2004 meeting. (Contact: Dr. Jeffrey Elias, BSR, Ph: 301-594-5942)
Performance Measures/Vignettes in Large Scale Surveys. This exploratory workshop will be held in June 2004. BSR frequently funds demographic and epidemiological population-based studies that have historically relied on self-report measures of disability (e.g., traditional Activities of Daily Living [ADL] and Instrumental Activities of Daily Living [IADL] scales) to assess physical functioning. BSR is planning this workshop to develop a set of recommended performance tests that BSR Program staff might encourage researchers to use, when appropriate, in BSR-funded studies. (Contact: Ms. Angie Chon-Lee, BSR, 301-594-5943)
As described at the Council meeting in May 2003, The Center for Scientific Review has formed an integrated review group (IRG) focused on The Biology of Development and Aging (BDA). The BDA IRG will review research applications that are focused on Development and/or Aging and that employ approaches at a variety of levels from molecules to whole organisms. Development and Aging are inherently integrative research areas focusing on biological changes over time. Proposals in this IRG will frequently transcend the boundaries of single organs or systems.
The BDA Study Sections are:Development 1 (DEV1)Development 2 (DEV2)Cellular Mechanisms in Aging and Development (CMAD)Aging Systems and Geriatrics (ASG)
The Office of Communications and Public Liaison recently received several awards and honors including Gold Awards from the National Mature Media for Aging Under the Microscope: A Biological Quest; Alzheimer's Disease: Unraveling the Mystery; and the ADEAR website (www.alzheimers.org). The Age Page - Nutrition and Home Safety for People with Alzheimer's Disease were both MERIT awardees. The ADEAR website also was selected as a finalist for the 2003 Government Customer Service Awards. Home Safety for People with Alzheimer's Disease received a 2003 APEX Award in the category of most improved brochure, manuals, and reports. (Contact Jane E. Shure, OCPL, Ph: 301-496-1752)
Stahl, Sidney M. and Lisa Vasquez. (Forthcoming) "Approaches to improving recruitment and retention in minority elders participating in research: Examples from selected research groups, including the NIA's RCMARs." Journal of Aging and Health
Quadagno, Jill and Sidney M. Stahl. 2003. "Challenges in nursing home care: A research agenda." The Gerontologist 43(Special Issue II):4-6.
Quadagno, Jill, Sidney Stahl, Laurence G. Branch, eds. 2003. "Challenges in nursing home care." The Gerontologist 43(Special Issue II).
Pillemer, Karl, Sara Czaja, Richard Schulz, and Sidney M. Stahl. 2003. "Finding the best ways to help: Opportunities and challenges of intervention research on aging." The Gerontologist 43(Special Issue I):5-8.
Stahl, Sidney M. and Kimberly M. Firth. 2002. "National Institute on Aging." Vol. 3, pp 974-977 in Encyclopedia of Aging, edited by D.J. Ekerdt. New York: Macmillan.
Planned and Sponsored Special Issue of The Gerontologist, Vol. 42, October 2002, "End-of-Life Research: Focus on Older Populations."
Levy, Judith A., Marcia G. Ory, and Stephen Crystal, guest editors. "The Graying of the AIDS Epidemic: HIV/AIDS and People Age 50 and Older." JAIDS: Journal of Acquired Immune Deficiency Syndromes. Volume 33, Supplement 2. June 1, 2003. (This supplement was funded by the National Institute on Aging).
Pillemer, Karl, Sara J. Czaja, and Richard Schulz, guest editors. March 2003. "Challenges of Translational Research on Aging: The Experience of the Roybal Centers. The Gerontologist. Volume 43, Special Issue I. (In addition to funding the individual Roybal Centers, the NIA provided a supplemental grant to Cornell University for coordinated dissemination of Center findings. This funding made this issue possible).
Berch, D. B., and M. V Wagster. (In press) "Future directions in cognitive aging research: Perspectives from the National Institute on Aging." In New Frontiers in Cognitive Aging edited by R. A. Dixon, L. Backman, & L. Nilsson. New York: Oxford University Press.
National Research Council, Committee on National Statistics and Committee on Law and Justice, Division of Behavioral and Social Sciences and Education. (2003) Elder Mistreatment: Abuse, Neglect, and Exploitation in an Aging America. Edited by R.J. Bonnie and R.B. Wallace. Washington, DC: The National Academies Press. (This book is the product of a study supported by Contract/Grant No. N01-OD-4-2139 between NAS and the NIA/BSR).
The following publications were updated or reprinted:
(Contact Jane E. Shure, Communications Officer, OCPL, Ph: 301-496-1752)
NIA Deputy Director Judith Salerno, M.D., participated in the NIH Science in the Cinema program. At a screening of the film Iris, Dr. Salerno presented information about Alzheimer's disease and fielded audience questions along with Dr. Morrison-Bogorad, associate director of NIA's Neuroscience and Neuropsychology of Aging Program. At NIA's invitation, a representative of the local Alzheimer's Association answered questions after the film and presentation.
NIA and ADEAR health publications were distributed at a variety of meetings and exhibits including the American Geriatrics Society, the American Academy of Physician Assistants, the National Association of Area Agencies on Aging, the National Association of Hispanic Nurses, the National Black Nurses Association, the Alzheimer's Association National Capital Area Research Conference, the Alzheimer's Association Education Conference, and the Common Ground Powwow in LaPlata, MD. (Contact Jane E. Shure, Communications Officer, OCPL, Ph: 301-496-1752)
Over 10 news releases were distributed on research findings ranging from a study suggesting that anemia elevates the risk of physical decline in older people to announcing that rates of dementia increase among older women on combination hormone therapy. The most current NIA press releases can be found online at http://www.nia.nih.gov/NewsAndEvents/. (Contact Jane E. Shure, Communications Officer, OCPL, Ph: 301-496-1752)
From the NIH GUIDE - From September 5, 2002 – January 7, 2003Published since the last National Advisory Council on Aging Meeting.Also check our NIA website “Current Funding Opportunities”(Shown here are selected Notices relevant to NIA and selected Initiatives)
Notice of Correction - Centers on the Demography of Aging (RFA: AG-04-001)Release Date: August 19, 2003Notice: NOT-AG-03-005 (This notice is in reference to RFA: AG-04-001)http://grants1.nih.gov/grants/guide/notice-files/NOT-AG-03-005.htmlThis notice is intended to correct and clarify the page limitation information given in RFA: AG-04-001. The page limitation for Cores is 20 pages.
Requirement of Duns NumberRelease Date: August 14, 2003Notice: NOT-OD-03-055http://grants1.nih.gov/grants/guide/notice-files/NOT-OD-03-055.html.Effective October 1, 2003, use of the Dun and Bradstreet (D&B) Data Universal Numbering System (DUNS) number will be required when applying for Federal grants or cooperative agreements. See June 27, 2003 Office of Management and Budget Federal Register Notice http://a257.g.akamaitech.net/7/257/2422/14mar20010800/edocket. access.gpo.gov/2003/03-16356.htm. A DUNS number must be included in every application for a new or competing continuation grant or cooperative agreement. The identifier will be used for tracking purposes, and to validate address and point of contact information. The DUNS number will be required whether an applicant is submitting a paper application, or using the NIH Commons or Grants.gov to submit the application.
NIA Announces New DNA Microarray Facility for Aging ResearchRelease Date: August 14, 2003Notice: NOT-AG-03-004http://grants1.nih.gov/grants/guide/notice-files/NOT-AG-03-004.htmlThis Notice announces the establishment of the NIA DNA Microarray Facility, which will provide filter arrays of the 17K mouse cDNA clone set developed at the NIA Intramural Research Program Laboratory of Genetics, as described in Tanaka et al. (2000) Genome-wide expression profiling of mid-gestation placenta and embryo using 15k mouse developmental cDNA microarray. PNAS 97:9127-9132. The clones were derived from early embryonic cDNA libraries and a description of the clone set has been published [Kargul et al. (2001) Verification and initial annotation of the NIA mouse 15K cDNA clone set. Nature Genetics 28:17-18]. Information on the 15K clone set, including gene ID's, is also available from the Laboratory of Genetics website (http://lgsun.grc.nia.nih.gov/cDNA/cDNA.html).
Small Business Eligibility Requirements for Applicants to the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) ProgramsRelease Date: July 25, 2003Notice: NOT-OD-03-053http://grants1.nih.gov/grants/guide/notice-files/NOT-OD-03-053.htmlNational Institutes of Health (NIH)The purpose of this notice is to restate the eligibility requirements for a small business concern to participate in the NIH SBIR and STTR programs, and to express that NIH has not adopted any new policies concerning eligibility. Questions regarding eligibility requirements for the SBIR program, can be directed to the SBA Government Contracting Area Director that has cognizance over the state in which your firm is located. Please click on the following web link to find the appropriate SBA office: http://www.sba.gov/size/indexcontacts.html
Correction to the Centers on the Demography of Aging RFARelease Date: July 9, 2003Notice: NOT-AG-03-003 (this notice is in reference to RFA AG-04-001)http://grants1.nih.gov/grants/guide/notice-files/NOT-AG-03-003.htmlThe National Institute on Aging (NIA) wishes to correct an error in the RFA entitled "Centers on the Demography of Aging (P30)" which was originally published in the NIH Guide to Grants and Contracts at http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-04-001.html. The National Institute on Aging (NIA) wishes to inform applicants to the Centers on the Demography of Aging RFA that the section entitled "Submitting An Application /Supplemental Instructions" incorrectly instructed applicants to give examples of only two projects in the Program Development (Pilot) Core. Instructions under 'Research Objectives" in the section entitled "Description of a Center" under "Program Development Core (Mandatory)" are correct. This section instructs applicants to "describe the proposed use of program development funds for two, and only two, pilot projects in each of the first two years of the proposed center." The applicant, therefore, is instructed to describe a total of four pilot projects, two in the first year and two in the second year.
Inactivation of Program Announcement: Mechanisms in HIV Dementia and Other CNS Diseases (PAS-00-065)Release Date: May 19, 2003Notice: NOT-NS-03-018http://grants.nih.gov/grants/guide/notice-files/NOT-NS-03-018.htmlThe purpose of this notice is to alert the scientific community that effective with the June 1, 2003 receipt date, the program announcement "Mechanisms in HIV Dementia and Other CNS Disease," PAS-00-065 (http://grants.nih.gov/grants/guide/pa-files/PAS-00-065.html) is no longer active, and applications in response to PAS-00-065 will no longer be accepted. The sponsoring Institutes may release a new program announcement in the future if it is determined that there is continuing need to solicit applications in this area.
Biospecimen Resources for Aging ResearchRelease Date: May 8, 2003Notice: NOT-AG-03-002http://grants1.nih.gov/grants/guide/notice-files/NOT-AG-03-002.htmlThis initiative supports longitudinal studies of human aging, some of which have developed repositories of biospecimens available for sharing. To facilitate access to human biospecimens and foster collaborative research with ongoing studies, the NIA announces a new website, the NIA Virtual Repository (http://www.nia.nih.gov/ResearchInformation/ScientificResources/Repository.htm). This website provides a central portal from which investigators can access information about human biospecimen repositories associated with extramural and intramural studies supported by the NIA.
(Sorted by most recent release date)
Research on the Reduction and Prevention of Suicidality Release Date: August 7, 2003PA Number: PA-03-161http://grants1.nih.gov/grants/guide/pa-files/PA-03-161.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of this PAThis initiative invites grant applications for research that will reduce the burden of suicidality (deaths, attempts, and ideation). While NIMH has a long-standing commitment to studying the mental health-related factors contributing to suicide risk, NIDA, NIAAA, NCI, and NIA supported research in suicidality is growing and has provided a broader perspective on the range of risk and protective factors. For this PA, mental disorders, along with alcohol use disorders (AUDs) and substance use disorders (SUDs) and their respective trajectories, are of particular interest as they pertain to risk and protective factors and treatment efficacy and effectiveness for suicidality. The intent of the program announcement is to intensify investigator-initiated research on this topic, to attract new investigators to the field, and increase interdisciplinary approaches to developing effective strategies to reduce suicidality.Direct your questions about scientific/research issues to:Sidney M. Stahl, Ph.D.Behavioral and Social Research ProgramNational Institute on Aging7201 Wisconsin Avenue, Room 533,MSC 9205Bethesda, MD 20892-9205Telephone: (301) 402-4156FAX: (301) 402-0051Email: Sidney_Stahl@nih.gov
Insulin Signaling and Receptor Cross-Talk Release Date: July 28, 2003PA Number: PA-03-156http://grants1.nih.gov/grants/guide/pa-files/PA-03-156.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of this PAThis initiative invites investigator-initiated research grant applications that will investigate crosstalk in insulin responses at molecular, cellular, and physiological levels. The purpose of this initiative is to stimulate novel and innovative research into the fundamental mechanism(s) of action of the insulin receptor in target tissues in the context of other cellular receptors and signaling pathways, and to broaden our understanding of how insulin signals act to regulate coordinated responses between and among insulin responsive tissues. Of particular interest is how such signaling interactions may affect the development and/or progression of diabetes and its complications. This program announcement replaces PAS 99-112.Direct your questions about scientific/research issues to:Frank Bellino, Ph.D.Biology of Aging Program National Institute on Aging Gateway Building, Suite 2C231Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010Email: bellinof@nia.nih.gov
Research on Mind-Body Interactions and HealthRelease Date: July 14, 2003RFA: OD-03-008http://grants1.nih.gov/grants/guide/rfa-files/RFA-OD-03-008.htmlApplication Receipt Dates: December 17, 2003Purpose of this RFAThis initiative invites applications in support of research on mind-body interactions and health. "Mind-body interactions and health" refers to the relationships among cognitions, emotions, personality, social relationships, and health. Applicant institutions may request funds to conduct regular research projects (R01). A central goal of this program is to encourage interdisciplinary collaboration and innovation towards understanding the processes underlying mind-body interactions and health as well as towards the application of such basic knowledge into interventions and clinical practice in the promotion of health and the prevention or treatment of disease and disabilities.Direct inquiries regarding general issues to:Ronald P. Abeles, Ph.D.Office of Behavioral and Social ResearchOffice of the DirectorNational Institutes of HealthGateway Building, Room 2C234, MSC 92057201 Wisconsin AvenueBethesda, MD 20892-9205Phone: 301-496-7859E-mail: abeles@nih.gov Direct inquiries regarding research interests to:Jeffrey W. Elias, Ph.D.Individual Behavioral Processes BranchBehavioral & Social Research ProgramNational Institute on AgingGateway Bldg., Suite 533Bethesda, MD 20892Phone: 301-402-4156Fax: 301-402-0051Email: EliasJ@nia.nih.gov
Biobehavioral Pain Research Release Date: July 11, 2003PA Number: PA-03-152http://grants1.nih.gov/grants/guide/pa-files/PA-03-152.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of this PAThe purpose of this biobehavioral pain research program announcement (PA) is to inform the scientific community of the interests of the various institutes at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic and clinical studies on pain as they relate to the missions of these Institutes.Direct your questions about scientific/research issues to:Dr. Judith A. Finkelstein, Ph.D.Head, Office of NutritionDirector, Sensory/Motor Disorders of Aging ProgramNational Institute on AgingNeuroscience and Neuropsychology of AgingGateway Building, Suite 3507201 Wisconsin AvenueBethesda, MD 20892-9205Telephone: (301) 496-9350FAX: (301) 496-1494Email: jf119k@nih.gov
Genetic and Molecular Basis of LongevityRelease Date: July 10, 2003RFA: AG-04-003http://grants1.nih.gov/grants/guide/rfa-files/RFA-AG-04-003.htmlApplication Receipt Dates: October 22, 2003Purpose of this RFAThis initiative invites applications for new and competing renewal applications for research project grants (R01) to support basic research on the genetic and molecular basis of longevity. The goals of the "Genetic and Molecular Basis of Longevity" Request for Applications (RFA) are to identify and functionally characterize genes that play a role in determining and modulating longevity and health span and determine the molecular mechanism(s) of action of these Longevity Assurance Genes (LAGs). Longevity Assurance Genes are operationally defined as genes that: determine, modulate or promote longevity and extend health span; maintain cell, tissue and/or organ function; and regulate and/or maintain organismal homeostasis. Direct your questions about scientific/research issues to:Anna M. McCormick, Ph.D.Chief, Genetics and Cell Biology BranchGenetics Program DirectorBiology of Aging ProgramNational Institute on AgingGateway Building, Suite 2C231Bethesda, MD 20892-2292Telephone: (301) 496-6402FAX: (301) 402-0010Email: mccormia@nia.nih.gov
Age-Related Changes in Tissue Function: Underlying Biological MechanismsRelease Date: July 7, 2003PA Number: PA-03-147http://grants1.nih.gov/grants/guide/pa-files/PA-03-147.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of this PAThis program announcement is to solicit applications on biological mechanisms of aging in tissues and organs. Projects are encouraged that significantly advance basic biology research to understand how and why changes take place in tissues with age and how those changes relate to altered tissue and organ function. Projects that focus on molecular aspects, as well as cellular aspects of tissue aging, are encouraged. Projects that emphasize molecular and cellular changes that are common among tissues with aging are also encouraged, as are projects that compare mechanisms of aging change in different tissues. Projects must have a clear relevance to aging to be considered under this PA.Direct your questions about scientific/research issues to:Frank L. Bellino, Ph.D.Endocrinology and PhysiologyNational Institute on Aging, NIH, DHHS7201 Wisconsin Avenue, Suite 2C231 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010Email: bellinof@nia.nih.govJill L. Carrington, Ph.D.Chief, Systems Branch, Biology of Aging ProgramMusculoskeletal BiologyNational Institute on Aging, NIH, DHHS7201 Wisconsin Avenue, Suite 2C231 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010Email: carringtonj@nia.nih.govDavid B. Finkelstein, Ph.D.Cardiovascular BiologyNational Institute on Aging, NIH, DHHS7201 Wisconsin Avenue, Suite 2C231 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010Email: finkelsd@nia.nih.govRebecca A. Fuldner, Ph.D.ImmunologyNational Institute on Aging, NIH, DHHS7201 Wisconsin Avenue, Suite 2C231 MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010Email: fuldnerr@nia.nih.govStanley Slater, M.D.Geriatrics and Clinical Gerontology ProgramNational Institute on Aging, NIH, DHHS7201 Wisconsin Avenue, Suite 3E327Bethesda, MD 20892-9205Telephone: (301) 496-6761FAX: (301) 402-1784Email: slaters@nia.nih.govBradley C. Wise, Ph.D.Neuroscience and Neuropsychology of Aging ProgramNational Institute on Aging, NIH, DHHS7201 Wisconsin Avenue, Suite 350Bethesda, MD 20892-9205Telephone: (301) 496-9350FAX: (301) 496-1494Email: wiseb@nia.nih.gov
Ubiquitin and Ubiquitin-Like Modifications Regulating Disease Processes Release Date: July 1, 2003PA Number: PA-03-145http://grants1.nih.gov/grants/guide/pa-files/PA-03-145.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of this PAThis initiative invites investigator-initiated research projects (R01 and R21) focused on elucidating the various roles of ubiquitin and ubiquitin-like modifications in the development, normal physiology and/or disease progression in cells, organs, and tissues of interest to NIDDK, NCI, and NIA. The NIDDK supports research pertaining to diabetes, endocrine and metabolic diseases; nutritional disorders, obesity and digestive diseases; and kidney, urologic and hematologic diseases. The NIA supports research pertaining to the basic biology of aging and age-associated diseases in various models including, but not limited to, tissue culture models and other cell-based paradigms, and tissues such as heart, muscle, brain and prostate.Direct your questions about scientific/research issues to:Felipe Sierra, Ph.D.Program DirectorBiology of Aging ProgramNational Institute on AgingGateway Building, Room 2C231Bethesda, MD 20892Tel: (301) 496-6402FAX: (301) 402-0010E-mail: fs78n@nih.gov
Centers on the Demography of Aging Release Date: June 17, 2003 (see correction NOT-AG-03-003)RFA: AG-04-001http://grants1.nih.gov/grants/guide/rfa-files/RFA-AG-04-001.htmlApplication Receipt Dates: October 22, 2003Purpose of this RFAThis initiative invites both new teams of investigators and continuing centers (funded under RFA AG-99-001) to apply. The purpose of these center grants is to support: the infrastructure and pilot data necessary for research and program development in selected areas (described under Research Objectives); research projects in selected areas (described under Research Objectives); the development of innovative national and international networks of researchers; the recruitment of new researchers into the field; the development and enhanced sharing of specialized databases and the rapid application of research results from these databases; and the development of statistical data enclaves for the analysis of large-scale, often-longitudinal, databases with linked administrative data.Direct your questions about scientific/research issues to:Georgeanne E. PatmiosBehavioral and Social Research ProgramNational Institute on Aging7201 Wisconsin Avenue, Suite 533, MSC 9205Bethesda, MD 20892-9205Telephone: (301) 496-3138FAX: (301) 402-0051Email: PatmiosG@nia.nih.gov (e-mail correspondence is preferred)
Basic Research in the Bladder and Lower Urinary Tract Release Date: June 9, 2003PA Number: PA-03-136http://grants1.nih.gov/grants/guide/pa-files/PA-03-136.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of this PA This initiative invites applications for research studies which focus on basic cellular, molecular, genetic and developmental mechanisms of the normal and abnormal function of the bladder and lower urinary tract. An important goal of this initiative is to attract new and established investigators from a variety of basic science research areas to apply their knowledge, skills, and tools to studies of the bladder and lower urinary tract.Direct your questions about scientific/research issues to:Frank Bellino, Ph.D.Biology of Aging Program National Institute on Aging Gateway Building, Suite 2C231Bethesda, MD 20892-9205Telephone: (301) 496-6402FAX: (301) 402-0010Email: bellinof@nia.nih.gov
Genetics, Behavior, and Aging Release Date: May 23, 2003PA Number: PAS-03-128http://grants.nih.gov/grants/guide/pa-files/PAS-03-128.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of this PAThis program announcement (PA) solicits novel research integrating genetics, behavior and aging. Human and non-human studies are needed to advance our understanding of the genetic and environmental influences and processes affecting variability in behavior and its functional sequelae with age. Direct your questions about scientific/research issues with primary emphasis on behavioral and social research on aging to: Angie Chon-Lee, MPHBehavioral and Social Research Program National Institute on AgingGateway Building, Room 533Bethesda, MD 20892-9205Telephone: (301) 594 5943FAX: (301) 402-0051Email: Chon-LeA@nia.nih.govDirect your questions about scientific/research issues related to the nervous system as well as mechanisms underlying cognitive functioning to:Marilyn M. Miller, Ph.D.Neuroscience and Neuropsychology of Aging ProgramNational Institute on AgingGateway Building, Suite 3507201 Wisconsin AvenueBethesda, MD 20892-9205Telephone: (301) 496-9350FAX: (301) 496-1494Email: Millerm@nia.nih.gov
Global Health Research Initiative Program for New Foreign Investigators Release Date: May 16, 2003PA Number: PAR-03-118http://grants1.nih.gov/grants/guide/pa-files/PAR-03-118.htmlApplication Receipt Dates: August 25, 2003; August 25, 2004; August 25, 2005Purpose of this PAThis initiative intends to promote productive re-entry of NIH-trained foreign investigators from low-income countries into their home countries as part of a broader program to enhance the scientific research infrastructure in developing countries, to stimulate research on a wide variety of high priority health-related issues in these countries, and to advance NIH efforts to address health issues of global import. The specific goal of this initiative is to provide funding opportunities for the increasing pool of foreign biomedical and behavioral scientists, clinical investigators, nurses, and other health professionals with state-of-the-art knowledge of research methods to advance critical issues in global health upon their return to their home countries. After their term of research training, developing country participants supported by this PA are expected to continue independent and productive scientific careers, including expert training and consultation and/or research of biomedical issues within their home institutions.Direct your questions about scientific/research issues to:Marta L. Campbell, MPPChief, Office of International ActivitiesNational Institute on AgingNational Institutes of HealthBuilding 31, Room 5C059000 Rockville PikeBethesda, MD 20892Email: campbelm@nia.nih.gov
Frailty in Old Age: Pathophysiology and Interventions Release Date: May 13, 2003PA Number: PAS-03-122http://grants1.nih.gov/grants/guide/pa-files/PAS-03-122.htmlApplication Receipt Dates: Standard NIH Receipt Dateshttp://grants1.nih.gov/grants/funding/submissionschedule.htmPurpose of this PAThe aim of this program is to foster biomedical research that will enhance our understanding of the complex biology and pathophysiology underlying the geriatric syndrome of frailty. A second goal is to foster development and testing of novel interventions targeting pathways believed to play an important mechanistic role in the development and progression of frailty. This PA is intended to foster clinical research, including integrative biomedical research, some of which will incorporate the tools of molecular and cellular biology in the study of function and clinical outcome, and studies in appropriate animal models. A long-term goal is to provide the groundwork for the possible prevention of frailty in older persons.Direct your questions about scientific/research issues to:Andre J. Premen, Ph.D.Geriatrics & Clinical Gerontology Program National Institute on AgingGateway Building, Room 3C-307Bethesda, MD 20892-9205Telephone: (301) 496-6761FAX: (301) 402-1784Email: PremenA@nia.nih.gov
* As presented in the FY 2004 Congressional Justification.**Reflects FY 2003 Appropriation (post recission)Date: 08/05/03
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