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Jack Bishop, Ph.D.

Toxicology Branch

Jack Bishop, Ph.D.
Jack Bishop, Ph.D.

Tel (919) 541-1876
Fax (919) 316-4511
P.O. Box 12233
Mail Drop EC-01
Research Triangle Park, North Carolina 27709
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Jack Bishop, Ph.D., is a geneticist in the Toxicology Branch of the National Toxicology Program at the National Institute of Health’s National Institute of Environmental Health Sciences (NIH/NIEHS).  Bishop came to the NIEHS in 1985 from the U.S. Food and Drug Administration’s National Center for Toxicological Research in Jefferson, Arkansas where he spent 10 years investigating chemically induced mutagenesis in rodent germ cells.  Prior to that, Bishop was a Research Geneticist at the U.S. Department of Agriculture’s Honeybee Breeding and Stock Center Research Laboratory in Baton Rouge, Louisiana.

Bishop is the Project Officer for the multi-generation reproductive toxicology contract used to evaluate reproductive and developmental toxicity of chemicals of interest to the National Toxicology Program (NTP).  In addition to his duties as a Project Officer, he also conducts independent research studies of reproductive, developmental and genetic toxicity in rodent animal models as well as in human subjects.  He provides genetic toxicology support for the NTP and serves as a scientific resources for the TOB and the ETP developing research plans and protocols to meet Program objectives. 

Bishop has led the effort to develop biomarker assays for the NTP for the detection of genetic damage in rodent sperm, using fluorescence in situ hybridization (sperm-FISH) to identify and characterize mammalian germ cell mutagens.  He also serves as a Topic Manager for extramural Small Business Innovative Research Contracts and Grants.

Bishop has over 30 years expertise in germ cell mutagenesis and environmental toxicology, with emphasis in reproductive, developmental and genetic toxicology, and has published over 60 scholarly publications in these areas.  He has also given numerous invited presentations at national and international meetings.  He is currently Treasurer and Executive Board Member of the most prestigious scientific society in his field, the U.S. Environmental Mutagen Society (EMS), and Past President of the regional EMS, the Genotoxicity and Environmental Mutagen Society.

He received a B.A. in biology/chemistry from McMurry College, Abilene, Texas, in 1967, an M.S. in zoology from Louisiana State University, Baton Rouge, Louisiana in 1970 and a Ph.D. in genetics from Louisiana State University in1974.

Selected Publications

  1. Frias S, Van Hummelen P, Meistrich ML, Lowe XR, Hagemeister FB, Shelby MD, Bishop JB, Wyrobek AJ. (2003) NOVP chemotherapy for Hodgkin's disease transiently induces sperm aneuploidies associated with the major clinical aneuploidy syndromes involving chromosomes X, Y, 18, and 21.  Cancer Res. 63(1):44-51.
  2. Witt KL, Hughes LA, Burka LT, McFee AF, Mathews JM, Black SL, Bishop JB. (2003)  Mouse bone marrow micronucleus test results do not predict the germ cell mutagenicity of N-hydroxymethylacrylamide in the mouse dominant lethal assay.  Environ Mol Mutagen.41(2):111-20.
  3. Bishop JB. (2003) Female-specific reproductive toxicities following preconception exposure to xenobiotics.Adv Exp Med Biol. 2003;518:1-9.
  4. Hill FS, Marchetti F, Liechty M, Bishop J, Hozier J, Wyrobek AJ.(2003)   A new FISH assay to simultaneously detect structural and numerical chromosomal abnormalities in mouse sperm.  Mol Reprod Dev. 2003 Oct;66(2):172-80.
  5. Marchetti F, Bishop JB, Cosentino L, Moore II D, Wyrobek AJ (2003) Paternally transmitted chromosomal aberrations in mouse zygotes determine their embryonic fate.  Biol Reprod 70:616-624.
  6. Bishop JB, Witt KL, Tice RR, Wolfe GW (2004) Genetic damage detected in CD-1 mouse pups exposed perinatally to 3’-azido-3’-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage.  Environ Mol. Mutagen. 43(1):3-9.
  7. Bishop JB, Tani Y, Witt K, Johnson JA, Peddada S, Dunnick J, Nyska A (2004) Mitochondrial damage revealed by morphometric and semiquantitative analysis of mouse pup cardiomyocytes following in utero and postnatal exposure to zidovudine and lamivudine. Toxicol Sci 81:512-517.
  8. Witt KL, Tice RR, Wolfe GW, Bishop JB (2004) Genetic damage detected in CD-1 mouse pups exposed perinatally to 3’-azido-3’-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ Mol. Mutagen. 44:321-328.
  9. Zudova D, Wyrobek AJ, Bishop J, Marchetti F (2004) Impaired fertility in T-stock female mice after superovulation.  Reproduction 128:573-581.
  10. Ghanayem BI, Witt KL, El-Hadri L, Hoffler U, Kissling GE, Shelby MD, Bishop JB (2005) Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide:  evidence supporting a glycidamide-mediated effect. Biol Reprod 72:157-163.
  11. Marchetti F, Pearson FS, Bishop JB, Wyrobek AJ. (2006) Etoposide induces chromosomal abnormalities in mouse spermatocytes and stem cell spermatogonia.   Hum Reprod. 2006 Apr;21(4):888-95.
  12. Chan SS, Santos JH, Meyer JN, Mandavilli BS, Cook DL Jr, McCash CL, Kissling GE, Nyska A, Foley JF, van Houten B, Copeland WC, Walker VE, Witt KL, Bishop JB. (2006) Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.  Environ Mol Mutagen. 2006 Jan 4; [Epub ahead of print]PMID: 16395692 [PubMed - as supplied by publisher]

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