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Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Children
This study is currently recruiting participants.
Verified by National Institutes of Health Clinical Center (CC), December 2008
Sponsored by: National Institute of Mental Health (NIMH)
Information provided by: National Institutes of Health Clinical Center (CC) Identifier: NCT00001246

Magnetic Resonance Imaging (MRI) unlike X-rays and CT-scans does not use radiation to create a picture. MRI use as the name implies, magnetism to create pictures with excellent anatomical resolution. Functional MRIs are diagnostic tests that allow doctors to not only view anatomy, but physiology and function. It is for these reasons that MRIs are excellent methods for studying the brain.

In this study, researchers will use MRIs to assess brain anatomy and function in normal volunteers and patients with a variety of childhood onset psychiatric disorders. The disorders include attention deficit disorder, autism, congenital adrenal hyperplasia, childhood-onset schizophrenia, dyslexia, multidimensional impairment syndrome, obsessive compulsive disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection (PANDAS), stuttering, Sydenham's chorea, and Tourette's syndrome.

Results of the MRIs showing the anatomy of the brain and brain function will be compared across age, sex (gender), and diagnostic groups. Correlations between brain and behavioral measures will be examined for normal and clinical populations.

Autoimmune Disease
Congenital Adrenal Hyperplasia
Mental Disorder Diagnosed in Childhood
Neurologic Manifestations

Genetics Home Reference related topics: 21-hydroxylase deficiency chorea-acanthocytosis Klinefelter syndrome
MedlinePlus related topics: Anatomy Autoimmune Diseases Child Mental Health Endocrine Diseases MRI Scans Mental Health Obsessive-Compulsive Disorder Schizophrenia
Drug Information available for: Epinephrine Epinephrine bitartrate
U.S. FDA Resources
Study Type: Observational
Official Title: Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Controls

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 6000
Study Start Date: January 1989
Detailed Description:

Driven by the hypotheses that many of the most severe neuropsychiatric disorders of childhood onset are associated with deviations from the path of normal brain development, the neuroanatomical substrates of which can be detected by magnetic resonance imaging, we are acquiring brain images in healthy and neuropsychiatrically impaired subjects. To explore gene, brain, behavior relationships in health and illness we are also acquiring DNA along with clinical, behavioral, and cognitive data in singleton and twin populations. Controls and clinical populations are screened and characterized in behavioral, cognitive, and physical domains. Longitudinal brain MRI scans are acquired and analyzed using state-of-the-art image analysis techniques. Data from the project has resulted in seminal papers on Attention-Deficit/Hyperactivity Disorder, Childhood-Onset Schizophrenia, and normal pediatric brain development. The data from the normative project is unique in its longitudinal nature and sample size.


Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Clinical populations are included based on DSM-IV criteria.

Inclusion Requirements - Normal Volunteers

Healthy subjects consenting to participation in the study.


Exclusions - Normal Volunteers

Presence of any psychiatric disorders on structured psychiatric interview (DICA-IV).

Current or past use of psychiatric medication.

Special service needs in school.

Presence of known genetic conditions.

If under the age of 18, parent and teacher ratings greater than one SD of population means on ADHD/hyperactivity factors.

Presence or history of medical conditions known to affect cerebral anatomy.

Head injury with loss of consciousness.


Metal implants or other contraindications for MRI scanning.

Presence of metal objects, pregnancy, or inability to provide a specimen to rule out pregnancy in females over age 12.

  Contacts and Locations
Please refer to this study by its identifier: NCT00001246

Contact: Patient Recruitment and Public Liaison Office (800) 411-1222
Contact: TTY 1-866-411-1010

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
  More Information

NIH Clinical Center Detailed Web Page  This link exits the site

Study ID Numbers: 890006, 89-M-0006
Study First Received: November 3, 1999
Last Updated: December 10, 2008 Identifier: NCT00001246  
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Magnetic Resonance Imaging
Attention Deficit Hyperactivity Disorder
Childhood Onset Schizophrenia
Obsessive Compulsive Disorder
Sydenham's Chorea
Tourette's Disorder
Klinefelter's Syndrome
Congenital Adrenal Hyperplasia

Study placed in the following topic categories:
Gonadal Disorders
Adrenogenital Syndrome
Adrenal Gland Diseases
Adrenocortical Hyperfunction
Sex Differentiation Disorders
Metabolism, Inborn Errors
Signs and Symptoms
Adrenal hyperplasia
Attention Deficit Disorder with Hyperactivity
Mental Disorders
Autistic Disorder
Chorea minor
Klinefelter syndrome
Mental Disorders Diagnosed in Childhood
Adrenal Hyperplasia, Congenital
Obsessive-Compulsive Disorder
Autoimmune Diseases
Metabolic Diseases
Sydenham's chorea
Klinefelter Syndrome
Endocrine System Diseases
Tourette Syndrome
Genetic Diseases, Inborn

Additional relevant MeSH terms:
Pathologic Processes
Immune System Diseases
Nervous System Diseases
Steroid Metabolism, Inborn Errors processed this record on January 30, 2009