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Summaries & Associations of Study Results

TR-305 Chlorinated Paraffins: C23, 43% Chlorine

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http://ntp.niehs.nih.gov/go/9560

Target Organs and Levels of Evidence
NTP Technical Report Number 305

Produced from Chemtrack Database 09/19/01

CHEMICAL/ CAS NUMBER PEER REVIEW DATE PRIMARY USES ROUTE/EXPOSURE LEVELS STUDY LABORATORY
CHLORINATED PARAFFINS: C23, 43% CHLORINE
108171-27-3 		08/14/85 ADDITIVE IN EXTREME PRESSURE LUBRICANT; FLAME RETARDANT IN RUBBER, PLASTIC, AND PAINT Gavage FR: 0,100,300,900, MR: 0,1875,3750, M: 0,2500,5000 MG/KG/50 PER GROUP Southern Research Institute
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM):
MR: NO EVIDENCE
FR: EQUIVOCAL EVIDENCE ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 1/50 4/50 6/50 7/50
MM: CLEAR EVIDENCE HEMATOPOIETIC SYSTEM: LYMPHOMA 6/50 12/50 16/50
FM: EQUIVOCAL EVIDENCE LIVER: ADENOMA 3/50 2/49 7/50 OR CARCINOMA 1/50 1/49 6/50 COMBINED 4/50 3/49 10/50

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