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Selected Publications

Chromosome Stability Group

2002 - Present

  1. Jegga AG, Inga A, Menendez D., Aronow BJ, Resnick MA. Functional evolution of the p53 regulatory network through its target response elements. Proceedings of the National Academy of Sciences of the United States of America 2008 105(3):944-949. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18187580) Exit NIEHS
  2. Ma W , Resnick MA, Gordenin DA. Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis. Nucleic acids research 2008 36(6):1836-1846. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18267974) Exit NIEHS
  3. Storici, F., Bebenek, K., Kunkel, T. A., Gordenin, D., Resnick, M.A. RNA-templated DNA repair. Nature. 7142: 338-341, 2007. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17429354&query_hl=1&itool=pubmed_docsum Exit NIEHS Website
  4. Monti, P., Ciribilli, Y., Jodan, J., Menichini, P., Umbach, D., Resnick, M.A., Luzzato, L., Inga, A., Fronza, G. Transcriptional functionality of germline p53 Mutants influences cancer phenotype. Clinical Cancer Research 13: 3789-3795, 2007. [Abstract] http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17606709&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Exit NIEHS Website
  5. Menendez, D., Inga, A., Snipe, J., Krysiak, O., Schönfelder, G., Resnick, M.A. A single–nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1. Mol. Cell. Biol. 27: 2590-2560, 2007. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17242190&query_hl=16&itool=pubmed_docsum Exit NIEHS Website
  6. Menendez, D., Inga, A., Jordan, J., Resnick, M.A. Changing the p53 master regulatory network: ELEMENTary, my dear Mr. Watson. Oncogene 26: 2191-2201, 2007. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17401428&query_hl=20&itool=pubmed_docsum Exit NIEHS Website
  7. Storici, F., Snipe, J., Chan, G., Gordenin, D., Resnick, M.A. Conservative repair of a chromosomal double-strand break by single-strand DNA through two steps of annealing. Mol Cell Biol. 2006 Oct;26(20):7645-57. Epub 2006 Aug 14. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16908537&query_hl=8&itool=pubmed_docsum Exit NIEHS Website
  8. Menendez, D., Inga, A., Resnick, M.A. The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes. Mol. Cell Biol. 26: 2297-2308, 2006. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16508005&query_hl=20&itool=pubmed_docsum Exit NIEHS Website
  9. Menendez, D., Krysiak, O., Inga, A., Gehrandt, B., Resnick, M.A.*, Schönfelder, G.* *Equal contributors. A SNP in the FLT1 promoter integrates the VEGF system into the p53 transcriptional network. Proc. Nat. Acad. Sci. 103: 1406-1411, 2006. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16432214&query_hl=16&itool=pubmed_docsum Exit NIEHS Website
  10. Lewis, K., Karthikeyan, G., Cassiano, J., Resnick, M.A. Reduction in nucleosome assembly during new DNA synthesis impairs both major pathways of double-strand break repair. Nucleic Acid Res. 33: 4928-4939, 2005. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16141196&query_hl=34&itool=pubmed_docsum Exit NIEHS Website
  11. Inga, A., Raemon-Buettner, S.M., Borlak, J., Resnick, M.A. Functional dissection of sequence-specific NKX2.5 DNA binding domain mutations associated with human heart septation defects using a yeast-based system. Human Molecular Genetics 14: 1965-1975, 2005. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15917268&query_hl=38&itool=pubmed_docsum Exit NIEHS Website
  12. Tomso, D. J., Inga, A., Menendez, D., Pittman, G., Campbell, M., Bell, D. A., and Resnick, M. A. Identification of functionally distinct polymorphic sequences that are targets for p53 transactivation. Proc. Natl. Acad. Sci. USA, in press. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15843459&query_hl=42&itool=pubmed_docsum Exit NIEHS Website
  13. Jin, Y.H., Garg, P., Stith, C.M.W., Al-Refai, H., Sterling J. F., Murray, L. J. W., Kunkel, T.A., Resnick, M. A., Burgers, P. M., and Gordenin, D. A. The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains. Mol. Cell. Biol. :461-471, 2005. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15601866&query_hl=15&itool=pubmed_docsum Exit NIEHS Website
  14. Lobachev, K., Vitriol, E., Stemple, J., Resnick, M. A., and Bloom, K. Chromosome fragmentation after induction of a double-strand break is an active process prevented by the RMX repair complex. Curr. Biol. 14: 2107-2112, 2004. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15589152&query_hl=13&itool=pubmed_docsum Exit NIEHS Website
  15. Lewis, L. K., Storici, F., Van Komen, S., Calero, S., Sung, P., and Resnick, M. A. Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells. Genetics 166; 1701-1713, 2004. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15126391&query_hl=16&itool=pubmed_docsum Exit NIEHS Website
  16. Karthikeyan, G., K., Santos, J., Graseiwcz, M., van Houten, B., Copeland, Isaya, G., and Resnick, M.A. Reduction in frataxin causes progressive accumulation of mitochondrial damage. Human Mol. Genet. 12: 3331-3342, 2003. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14570713&query_hl=19&itool=pubmed_docsum Exit NIEHS Website
  17. Jin, Y. H., Clark, A. B., Slebos, R. J. C., Al-Refai, H., Taylor, J. A., Kunkel, T. A., Resnick, M. A., and Gordenin, D. A. Cadmium is a mutagen that acts by inhibiting mismatch repair. Nature Genet. 34: 326-329, 2003. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12796780&query_hl=21&itool=pubmed_docsum Exit NIEHS Website
  18. Resnick, M. A., and Inga, A. Functional mutations in the sequence-specific transcription factor p53 and implications for master genes of diversity. Proc. Nat. Acad. Sci. USA 100: 9934-9939, 2003. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12909720&query_hl=23&itool=pubmed_docsum Exit NIEHS Website
  19. Storici, F., Durham, C. L., Gordenin, D., and Resnick, M.A. Chromosomal site-specific double strand breaks are efficiently targeted for repair by oligonucleotides in yeast. Proc. Nat. Acad. Sci. USA, 100: 14994-14999, 2003. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14630945&query_hl=25&itool=pubmed_docsum Exit NIEHS Website
  20. Lobachev, K., Gordenin, G., and Resnick, M.A. The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell 108: 183-193, 2002. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11832209&query_hl=28&itool=pubmed_docsum Exit NIEHS Website
  21. Storici, F., Henneke, G., Gordenin, A., Hubscher, U., and Resnick, M.A. The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair. EMBO J. 21: 5930-5942, 2002. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12411510&query_hl=30&itool=pubmed_docsum Exit NIEHS Website
  22. Inga, A., Nahari, D., Velasco-Miguel, S. Friedberg, E.C., Resnick, M. A. A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions. Oncogene. 2002 Aug 22;21(37):5704-15. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12173040&query_hl=37&itool=pubmed_docsum Exit NIEHS Website
  23. Inga, A., Storici, F., Darden, T.A., Resnick, M.A. Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. Mol. Cell. Biol. 22: 8612-86125, 2002. [Abstract] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12446780&query_hl=39&itool=pubmed_docsum Exit NIEHS Website

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Last Reviewed: April 08, 2008