| Agent Name |
p-Dichlorobenzene |
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| Alternative Name |
1,4-Dichlorobenzene |
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| CAS Number |
106-46-7 |
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| Formula |
C6-H4-Cl2 |
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| Major Category |
Pesticides |
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| Synonyms |
p-DCB; para-Dichlorobenzene; Dichlorocide; 1,4-Dichlorobenzene; [NIOSH] |
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| Category |
Fumigants |
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| Description |
Colorless or white crystalline solid with a mothball-like odor. [insecticide]; [NIOSH] |
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| Sources/Uses |
Used as an insecticide and fumigant; [ACGIH] Used as a deodorizer for toilets and garbage cans; Also used as a moth repellent and chemical intermediate; [CHEMINFO] |
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| Comments |
After daily doses of 500 mg/kg, rats develop focal hepatic necrosis. TLV Basis: eye irritation and kidney damage; Humans report eye irritation at 17 ppm and higher. Renal toxicity is observed in animal experiments at 25 ppm and higher. Hemolytic anemia and jaundice have been reported after ingestion. [ACGIH] Experimental animals suffer CNS depression and liver and kidney damage after high-dose inhalation studies. [CHEMINFO] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
10 ppm |
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| PEL (OSHA) |
75 ppm |
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| IDLH (NIOSH) |
150 ppm |
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| Excerpts from Documentation for IDLHs |
No adverse effects were noted in a workplace averaging 105 ppm (range 50 to 170 ppm), but painful irritation of the eyes and nose was found at 80 to 160 ppm, and breathing was difficult at concentrations greater than 160 ppm [Hollingsworth et al. 1956]. |
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| Vapor Pressure |
1.3 mm Hg |
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| Odor Threshold Low |
0.12 ppm |
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| Odor Threshold High |
15 ppm |
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| Explanatory Notes |
Detection odor threshold from AIHA (mean = 0.12 ppm); Melting point = 53 deg C; [CHEMINFO] |
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| Reference Link |
ATSDR - ToxFAQs - 1,4-Dichlorobenzene |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Neurotoxin |
Other CNS Neurotoxin |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Nephrotoxin |
Yes |
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| IARC Carcinogen |
Possible Carcinogen |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: 1,4-DICHLOROBENZENE
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