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Sponsored by: |
National Institute of Mental Health (NIMH) |
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Information provided by: | National Institute of Mental Health (NIMH) |
ClinicalTrials.gov Identifier: | NCT00260182 |
This study will identify specific genes that may cause a predisposition to depression in some families.
Condition |
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Depression |
Study Type: | Observational |
Study Design: | Cohort, Retrospective |
Official Title: | Genetics of Recurrent Early Onset Major Depression |
Blood samples with DNA
Estimated Enrollment: | 1500 |
Study Start Date: | October 2005 |
Estimated Study Completion Date: | June 2009 |
Estimated Primary Completion Date: | June 2009 (Final data collection date for primary outcome measure) |
Depression is a serious medical illness that is often difficult to diagnose and treat. Studies on patterns of depression within families suggest that inherited genes may cause a predisposition to the disorder. People with early onset depression often have more relatives with depression than people whose depression does not begin until later in life. It is likely that several interacting genes cause this tendency towards the disorder, rather than one specific gene. This study will serve to identify particular genes that may cause a susceptibility to depression in order to better understand the brain mechanisms involved with severe depression. In turn, this may aid in the development of new treatments for depression.
Participation in this observational study will entail one interview and one blood test. Participants will be interviewed, either in person or by telephone, about their personal and family psychiatric history. The blood sample will be collected at a time and location that is convenient for the participant. Participants may also be asked to invite other family members to participate in the study.
Ages Eligible for Study: | 21 Years to 70 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
The study will include participants with a family history of depression.
Inclusion Criteria:
Exclusion Criteria:
Contact: GenRED Study | 650-723-3258 | genredstudy@stanford.edu |
Contact: Alex Zvinyatskovskiy, BA | 650-736-0481 | alexzv@stanford.edu |
United States, California | |
Stanford University | Recruiting |
Palo Alto, California, United States, 94304 | |
Contact: GenRED Study 650-723-3258 genredstudy@stanford.edu | |
Contact: Alex Zvinyatskovskiy, BA 650-736-0481 alexzv@stanford.edu | |
Principal Investigator: Douglas F. Levinson, MD | |
United States, District of Columbia | |
Howard University | Recruiting |
Washington, District of Columbia, United States, 20060 | |
Contact: Oreisa O'Neil, MPH 202-806-7642 ooneil04@yahoo.com | |
Contact: Eva Nwulia, MD | |
Principal Investigator: William Lawson, MD | |
United States, Illinois | |
Rush University Medical Center | Recruiting |
Chicago, Illinois, United States, 60612 | |
Contact: Karen Neimanas 888-820-3395 karen_neimanas@rush.edu | |
Principal Investigator: William A. Scheftner, MD | |
United States, Iowa | |
University of Iowa | Recruiting |
Iowa City, Iowa, United States, 52242 | |
Contact: Carol Moss 888-850-8531 carol-moss@uiowa.edu | |
Principal Investigator: William Coryell, MD | |
United States, Maryland | |
Johns Hopkins University | Recruiting |
Baltimore, Maryland, United States, 21287 | |
Contact: Meredith Goodell 410-614-1767 mgoodell@jhem.jhmi.edu | |
Principal Investigator: J. Raymond DePaulo, MD | |
United States, New York | |
Columbia University/New York State Psychiatric Institute | Recruiting |
New York, New York, United States, 10032 | |
Contact: Sadia Chaudhury 212-543-6731 chaudhus@childpsych.columbia.edu | |
Principal Investigator: Myrna W. Weissman, PhD |
Principal Investigator: | Douglas F. Levinson, MD | Stanford University |
Principal Investigator: | Myrna M. Weissman, PhD | Columbia University/New York State Psychiatric Institute |
Principal Investigator: | J. Raymond DePaulo, MD | Johns Hopkins University |
Principal Investigator: | William A. Scheftner, MD | Rush University Medical Center |
Principal Investigator: | William Coryell, MD | University of Iowa |
Principal Investigator: | William Lawson, MD | Howard University |
Responsible Party: | Stanford University ( GenRED Study ) |
Study ID Numbers: | R01 MH61686-05, R01 MH059542, R01 MH059552, R01 MH075131, R01 MH059541, R01 MH060912, DNBBS 7G-GRR |
Study First Received: | November 28, 2005 |
Last Updated: | November 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00260182 |
Health Authority: | United States: Federal Government |
Depressive Disorder Family Genetics |
Depression Mental Disorders Mood Disorders Depressive Disorder, Major |
Depressive Disorder Recurrence Behavioral Symptoms |