Cognitive Behavioral Therapy Plus Motivational Interviewing for Treatment of Obsessive-Compulsive Disorder - Full Text View

Sponsored by:	National Institute of Mental Health (NIMH)
Information provided by:	National Institute of Mental Health (NIMH)
ClinicalTrials.gov Identifier:	NCT00316316

Purpose

This study will determine the effectiveness of adding motivational interviewing to cognitive behavioral therapy, consisting of exposure and ritual prevention, in improving treatment outcomes in people with obsessive-compulsive disorder.

Condition	Intervention	Phase
Obsessive-Compulsive Disorder	Behavioral: Motivational interviewing plus exposure and response prevention (MI plus EX/RP) Behavioral: Exposure and response prevention (EX/RP)	Phase I

MedlinePlus related topics: Obsessive-Compulsive Disorder

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Single Blind (Outcomes Assessor), Active Control, Parallel Assignment, Efficacy Study
Official Title:	Cognitive Behavioral Therapy Plus Motivational Interviewing for Obsessive Compulsive Disorder

Further study details as provided by National Institute of Mental Health (NIMH):

Primary Outcome Measures:

Obsessive-compulsive symptoms [ Time Frame: Measured at Months 2 and 8 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Adherence, depression, insight, and quality of life [ Time Frame: Measured at Months 2 and 8 ] [ Designated as safety issue: No ]

Estimated Enrollment:	34
Study Start Date:	March 2006
Estimated Study Completion Date:	March 2009
Estimated Primary Completion Date:	March 2009 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: Active Comparator Participants will receive motivational interviewing plus exposure and response prevention	Behavioral: Motivational interviewing plus exposure and response prevention (MI plus EX/RP) Participants will receive 18 sessions of MI plus EX/RP.
2: Active Comparator Participants will receive exposure and response prevention only	Behavioral: Exposure and response prevention (EX/RP) Participants will receive 18 sessions of EX/RP.

Detailed Description:

Obsessive Compulsive Disorder (OCD) is a chronic and debilitating anxiety disorder. People with OCD often experience recurrent unwanted thoughts, or obsessions. Some examples of obsessions include the following: repetitive fears of causing harm or being harmed; fears of contamination and illness; fears of making mistakes; intrusive distressing sexual or religious imagery; and fears of losing things. In an effort to relieve anxiety about these obsessions, people with OCD develop repetitive behaviors called compulsions. Some examples of compulsions include the following: repetitive washing and cleaning; excessive checking; excessive ordering and arranging; and extreme hoarding and saving. These thoughts and behaviors interfere with everyday life to a great extent. Cognitive behavior therapy (CBT) with exposure and ritual prevention (EX/RP) is a standard treatment for OCD. EX/RP involves both imaginary and real exposure to situations or settings that may stimulate OCD behavior, and it requires that patients refrain from ritualizing. Motivational interviewing (MI) may help to enhance an individual's motivation to change by exploring and resolving ambivalence. This study will determine the effectiveness of adding MI to CBT that consists of EX/RP in improving treatment outcome in people with OCD.

Participants in this single-blind study will be randomly assigned to receive either standard CBT with EX/RP or CBT with EX/RP plus MI. All participants will report to the study site twice weekly for both therapy and assessments for a total of 2 months. Assessments will include interviews and self-rating forms. No medication will be administered during this study. However, participants will continue on any medication that they are taking at the time of study entry. All participants will be assessed for outcomes upon study completion. Participants who respond to therapy will be assessed again 6 months following study completion.

Eligibility

Ages Eligible for Study:	18 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Primary diagnosis of OCD

Exclusion Criteria:

Any additional medical or psychiatric conditions that could make participation in the study medically inadvisable
Currently receiving psychotherapy at another clinic

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00316316

Contacts

Contact: Jose Hernandez	212-543-5367
Contact: Jessica McCarthy	212-543-5380

Locations

United States, New York
New York State Psychiatric Institute	Recruiting
New York, New York, United States, 10032

Sponsors and Collaborators

National Institute of Mental Health (NIMH)

Investigators

Principal Investigator:

Helen Blair Simpson, MD, PhD

New York State Psychiatric Institute

More Information

Click here for the Obsessive-Compulsive Disorder Research Clinic website. This link exits the ClinicalTrials.gov site

Responsible Party:	New York State Psychiatric Institute ( Helen Blair Simpson, MD, PhD / Study Principal Investigator )
Study ID Numbers:	R34 MH71570, DAHBR 96-BHA
Study First Received:	April 18, 2006
Last Updated:	February 29, 2008
ClinicalTrials.gov Identifier:	NCT00316316
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Mental Health (NIMH):

OCD

Study placed in the following topic categories:

Anxiety Disorders
Mental Disorders
Obsessive-Compulsive Disorder

Additional relevant MeSH terms:

Pathologic Processes
Disease

ClinicalTrials.gov processed this record on January 30, 2009