Volume 4, Number 2 - June 2008

Challenges in Using Opioids to Treat Pain in Persons With Substance Use Disorders
[PDF - 740K]
Seddon R. Savage, M.D., M.S., Kenneth L. Kirsh, Ph.D., and Steven D. Passik, Ph.D.

Acosta, M., and Haller, D.L., 2006. Psychiatric and substance abuse comorbidity influences treatment outcomes in opioid-abusing patients. Paper presented at the College on Problems of Drug Dependency annual meeting, Scottsdale, AZ.

Adams, N.J., et al., 2001. Opioids and the treatment of chronic pain in a primary care sample. Journal of Pain and Symptom Management 22(3):791-796. Abstract Available

Akbik, H., et al., 2006. Validation and clinical application of the Screener and Opioid Assessment for Patients with Pain (SOAPP). Journal of Pain and Symptom Management 32(3):287-293. Abstract Available

Amabile, C.M., and Bowman, B.J., 2006. Overview of oral modified-release opioid products for the management of chronic pain. The Annals of Pharmacotherapy 40(7-8):1327-1335. Full Text Available

American Psychiatric Association, 2000. Diagnostic and Statistical Manual of Mental Disorders (4th ed., Text Revision; DSM-IV-TR). Washington, DC: American Psychiatric Association.

American Society of Addiction Medicine (ASAM), 2001. Definitions related to the use of opioids for the treatment of pain: A consensus document from the American Academy of Pain Medicine, the American Pain Society, and the American Society of Addiction Medicine. Glenview, IL: American Academy of Pain Medicine.

Angst, M.S., and Clark, J.D., 2006. Opioid-induced hyperalgesia: A qualitative systematic review. Anesthesiology 104(3):570-587. Full Text Available

Atluri, S., et al., 2003. Guidelines for the use of controlled substances in the management of chronic pain. Pain Physician 6(3):233-257. Full Text Available

Ballantyne, J.C., 2007. Opioid analgesia: Perspectives on right use and utility. Pain Physician 10(3):479-491. Full Text Available

Baron, M.J., and McDonald, P.W., 2006. Significant pain reduction in chronic pain patients after detoxification from high-dose opioids. Journal of Opioid Management 2(5):277-282. Abstract Available

Brems, C., et al., 2002. Rates and sequelae of the coexistence of substance use and other psychiatric disorders. International Journal of Circumpolar Health 61(3):224-244.

Brown, R.L., and Rounds, L.A., 1995. Conjoint screening questionnaires for alcohol and other drug abuse: Criterion validity in a primary care practice. Wisconsin Medical Journal 94(3):135-140.

Burton, A.W.; Bruehl, S.; and Harden, R.N., 2005. Current diagnosis and therapy of complex regional pain syndrome: Refining diagnostic criteria and therapeutic options. Expert Review of Neurotherapeutics 5(5):643-651. Abstract Available

Butler, S.F., et al., 2006. Development and validation of an Opioid Attractiveness Scale: A novel measure of the attractiveness of opioid products to potential abusers. Harm Reduction Journal 3:5. Full Text Available

Chang, G.; Chen, L.; and Mao, J., 2007. Opioid tolerance and hyperalgesia. The Medical Clinics of North America 91(2):199-211.

Cheatle, M.D., and Gallagher, R.M., 2006. Chronic pain and comorbid mood and substance use disorders: A biopsychosocial treatment approach. Current Psychiatry Reports 8(5):371-376.

Cohen, M.J., et al., 2002. Ethical perspectives: Opioid treatment of chronic pain in the context of addiction. The Clinical Journal of Pain 2002 18(4 Suppl.):S99-S107. Abstract Available

Collins, J.J., et al., 2005. The assessment of chronic health conditions on work performance, absence, and total economic impact for employers. Journal of Occupational and Environmental Medicine 47(6):547-557.

Curatolo, M., et al., 2006. Central hypersensitivity in chronic pain: Mechanisms and clinical implications. Physical Medicine and Rehabilitation Clinics of North America 17(2):287-302.

Devulder, J.; Richarz, U.; and Nataraja, S.H., 2005. Impact of long-term use of opioids on quality of life in patients with chronic, non-malignant pain. Current Medical Research and Opinion 21(10):1555-1568. Abstract Available

Drug Abuse Warning Network, 2002, Emergency Department Trends From the Drug Abuse Warning Network, Preliminary Estimates January-June 2002. Report No. D-22. Rockville, MD: Substance Abuse and Mental Health Services Administration.

Dunbar, S.A., and Katz, N.P., 1996. Chronic opioid therapy for nonmalignant pain in patients with a history of substance abuse: Report of 20 cases. Journal of Pain and Symptom Management 11(3):163-171. Abstract Available

Friedman, R.; Li, V.; and Mehrotra, D., 2003. Treating pain patients at risk: Evaluation of a screening tool in opioid-treated pain patients with and without addiction. Pain Medicine 4(2):182-185. Abstract Available

Furlan, A.D., et al., 2006. Opioids for chronic noncancer pain: A meta-analysis of effectiveness and side effects. Canadian Medical Association Journal 174(11):1589-1594. Full Text Available

Gaertner, J., et al., 2006. Assessing cognition and psychomotor function under long-term treatment with controlled release oxycodone in non-cancer pain patients. Acta Anaesthesiologica Scandinavica 50(6):664-672. Abstract Available

Gourlay, D.L.; Heit, H.A.; and Almahrezi, A., 2005. Universal precautions in pain medicine: A rational approach to the treatment of chronic pain. Pain Medicine 6(2):107-112. Abstract Available

Haythornthwaite, J.A., et al., 1998. Outcome of chronic opioid therapy for non-cancer pain. Journal of Pain and Symptom Management 15(3):185-194. Abstract Available

Heinemann, A.W., et al., 1988. Alcohol use by persons with recent spinal cord injury. Archives of Physical Medicine and Rehabilitation 69(8):619-624.

Hojsted, J., et al., 2006. Breakthrough pain in opioid-treated chronic non-malignant pain patients referred to a multidisciplinary pain centre: A preliminary study. Acta Anaesthesiologica Scandinavica 50(10):1290-1296. Abstract Available

Hughes, A.A.; Bogdan, G.M.; and Dart, R.C., 2007. Active surveillance of abused and misused prescription opioids using poison center data: A pilot study and descriptive comparison. Clinical Toxicology (Philadelphia, Pa.) 45(2):144-151. Abstract Available

Hurd, Y.L., 2006. Perspectives on current directions in the neurobiology of addiction disorders relevant to genetic risk factors. CNS Spectrums 11(11):855-862.

IASP Task Force on Taxonomy, 1994. Part III: Pain terms, a current list with definitions and notes on usage. In: H. Merskey and N. Bogduk (Eds.), Classification of Chronic Pain (2nd ed.). Seattle, WA: IASP Press, pp. 209-214.

Inturrisi, C.E., 2002. Clinical pharmacology of opioids for pain. The Clinical Journal of Pain 18(4 Suppl.):S3-S13. Abstract Available

Inturrisi, C.E., 2005. Pharmacology of methadone and its isomers. Minerva Anestesiologica 71(7-8):435-437. Abstract Available

Ives, T.J., et al., 2006. Predictors of opioid misuse in patients with chronic pain: A prospective cohort study. BMC Health Services Research 6:46.

Jensen, T.S., and Lenz, F.A., 1995. Central post-stroke pain: A challenge for the scientist and the clinician. Pain 61(2):161-164.

Joranson, D.E., and Gilson, A.M., 2005. Drug crime is a source of abused pain medications in the United States. Journal of Pain and Symptom Management 30(4):299-301. Full Text Available

Kahan, M., et al., 2006. Misuse of and dependence on opioids: Study of chronic pain patients. Canadian Family Physician 52(9):1081-1087. Abstract Available

Kalso, E., et al., 2004. Opioids in chronic non-cancer pain: Systematic review of efficacy and safety. Pain 112(3):372-380. Abstract Available

Katz, N., and Fanciullo, G.J., 2002. Role of urine toxicology testing in the management of chronic opioid therapy. The Clinical Journal of Pain 18(4 Suppl.):S76-S82. Abstract Available

Kim, H., et al., 2004. Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament. Pain 109(3):488-496.

Kreek, M.J., 1973. Medical safety and side effects of methadone in tolerant individuals. The Journal of the American Medical Association 223(6):665-668.

Lanas, A., et al., 2005. A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use. The American Journal of Gastroenterology 100(8):1685-1693. Abstract Available

Mackey, S.C., and Maeda, F., 2004. Functional imaging and the neural systems of chronic pain. Neurosurgery Clinics of North America 15(3):269-288.

Manchikanti, L., et al., 2005. Evaluation of abuse of prescription and illicit drugs in chronic pain patients receiving short-acting (hydrocodone) or long-acting (methadone) opioids. Pain Physician 8(3):257-261. Full Text Available

Marsch, L.A., et al., 2001. Effects of infusion rate of intravenously administered morphine on physiological, psychomotor, and self-reported measures in humans. The Journal of Pharmacology and Experimental Therapeutics 299(3):1056-1065. Abstract Available

Martell, B.A., et al., 2007. Systematic review: Opioid treatment for chronic back pain: Prevalence, efficacy, and association with addiction. Annals of Internal Medicine 146(2):116-127. Full Text Available

McCarberg, B.H., and Billington, R., 2006. Consequences of neuropathic pain: Quality-of-life issues and associated costs. American Journal of Managed Care 12(9 Suppl.):S263- S268.

Mease, P., 2005. Fibromyalgia syndrome: Review of clinical presentation, pathogenesis, outcome measures, and treatment. The Journal of Rheumatology. Supplement 75:6-21. Full Text Available

Mercadante, S., 1999. Opioid rotation for cancer pain: Rationale and clinical aspects. Cancer 86(9):1856-1866. Full Text Available

Merskey, H., and Bogduk, N., 2004. Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms (2d ed.). Seattle, WA: IASP Press.

Michna, E., et al., 2007. Urine toxicology screening among chronic pain patients on opioid therapy: Frequency and predictability of abnormal findings. The Clinical Journal of Pain 23(2):173-179. Abstract Available

Moore, R.D., 1989. Prevalence, detection, and treatment of alcoholism in hospitalized patients. The Journal of the American Medical Association 261(3):403-407. Abstract Available

National Institute on Alcohol Abuse and Alcoholism, 1998. Drinking in the United States: Main Findings From the 1992 National Longitudinal Alcohol Epidemiologic Survey (NLAES) NIH Publication No. 99-3519. Rockville, MD: National Institute on Alcohol Abuse and Alcoholism.

Noble, M., et al., 2008. Long-term opioid therapy for chronic noncancer pain: A systematic review and meta-analysis of efficacy and safety. Journal of Pain Management 35(2):214- 228. Abstract Available

Norman, S.B., et al., 2007. Do trauma history and PTSD symptoms influence addiction relapse context? Drug and Alcohol Dependence 90(1):89-96. Abstract Available

Nourjah, P., et al., 2006. Estimates of acetaminophen (Paracetomal)-associated overdoses in the United States. Pharmacoepidemiology and Drug Safety 15(6):398-405. Abstract Available

Passik, S.D., et al., 2005. Monitoring outcomes during long-term opioid therapy for noncancer pain: Results with the Pain Assessment and Documentation Tool. Journal of Opioid Management 1(5):257-266. Abstract Available

Passik, S.D., et al., 2006a. Psychiatric and pain characteristics of prescription drug abusers entering drug rehabilitation. Journal of Pain and Palliative Care Pharmacotherapy 20(2):5-13. Abstract Available

Passik, S.D., et al., 2006b. Pain and aberrant drug-related behaviors in medically ill patients with and without histories of substance abuse. The Clinical Journal of Pain 22(2):173-181. Abstract Available

Pasternak, G.W., 2005. Molecular biology of opioid analgesia. Journal of Pain and Symptom Management 29(5 Suppl.):S2-S9. Abstract Available

Peles, E., et al., 2007. Corrected-QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients: A cross-sectional study. Addiction 102(2):289-300. Abstract Available

Portenoy, R.K., et al., 2007. Long-term use of controlled-release oxycodone for noncancer pain: Results of a 3-year registry study. The Clinical Journal of Pain 23(4):287-299. Abstract Available

Portenoy, R.K., and Foley, K.M., 1986. Chronic use of opioid analgesics in non-malignant pain: Report of 38 cases. Pain 25(2):171-186. Abstract Available

Pud, D., et al., 2006. Opioids and abnormal pain perception: New evidence from a study of chronic opioid addicts and healthy subjects. Drug and Alcohol Dependence 82(3):218-223. Abstract Available

Rosenblum, A., et al., 2003. Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. The Journal of the American Medical Association 289(18):2370-2378. Abstract Available

Rupp, T., and Delaney, K.A., 2004. Inadequate analgesia in emergency medicine. Annals of Emergency Medicine 43(4):494-503. Abstract Available

Savage, S.R., 1993. Addiction in the treatment of pain: Significance, recognition, and management. Journal of Pain and Symptom Management 8(5):265-278. Abstract Available

Scimeca, M.M., et al., 2000. Treatment of pain in methadone-maintained patients. The Mount Sinai Journal of Medicine 67(5-6):412-422. Full Text Available

Sees, K.L., and Clark, H.W., 1993. Opioid use in the treatment of chronic pain: Assessment of addiction. Journal of Pain and Symptom Management 8(5):257-264. Abstract Available

Substance Abuse and Mental Health Services Administration (SAMHSA), 2007. Results from the 2006 National Survey on Drug Use and Health: National Findings. DHHS Publication No. SMA 05-4062. Rockville, MD: Substance Abuse and Mental Health Services Administration, Office of Applied Studies.

Sullivan, M.D., et al., 2005. Regular use of prescribed opioids: Association with common psychiatric disorders. Pain 119(1-3):95-103. Abstract Available

Thomsen, A.B.; Becker, N.; and Eriksen, J., 1999. Opioid rotation in chronic non-malignant pain patients: A retrospective study. Acta Anaesthesiologica Scandinavica 43(9):918-923. Abstract Available

Turner, J.A.; Holtzman, S.; and Mancl, L., 2007. Mediators, moderators, and predictors of therapeutic change in cognitive-behavioral therapy for chronic pain. Pain 127(3):276-286. Abstract Available

Vadivelu, N., and Hines, R.L., 2007. Buprenorphine: A unique opioid with broad clinical applications. Journal of Opioid Management 3(1):49-58. Abstract Available

Wasan, A.D., et al., 2006. Iatrogenic addiction in patients treated for acute or subacute pain: A systematic review. Journal of Opioid Management 2(1):16-22. Abstract Available

Webster, L.R., and Webster, R.M., 2005. Predicting aberrant behaviors in opioid-treated patients: Preliminary validation of the Opioid Risk Tool. Pain Medicine 6(6):432-442. Abstract Available

Weissman, D.E., and Haddox, J.D., 1989. Opioid pseudoaddiction--An iatrogenic syndrome. Pain 36(3):363-366. Abstract Available

Wiedemer, N.L., et al., 2007. The opioid renewal clinic: A primary care, managed approach to opioid therapy in chronic pain patients at risk for substance abuse. Pain Medicine 8(7): 573-584. Abstract Available

Wu, S.M., et al., 2006. The Addiction Behaviors Checklist: Validation of a new clinician-based measure of inappropriate opioid use in chronic pain. Journal of Pain and Symptom Management 32(4):342-351. Abstract Available

Young Casey, C., et al., 2008. Transition from acute to chronic pain and disability: A model including cognitive, affective, and trauma factors. Pain 134(1-2):69-79. Abstract Available

Zacny, J.P., 1996. Should people taking opioids for medical reasons be allowed to work and drive? Addiction 91(11):1581-1584.

Zacny, J.P., et al., 1996. The effects of a cold-water immersion stressor on the reinforcing and subjective effects of fentanyl in healthy volunteers. Drug and Alcohol Dependence 42(2):133-142. Abstract Available

RESPONSE: PROVIDING RELIEF, AVOIDING EUPHORIA
[PDF - 104K]

Savage, S.R.; Kirsh, K.L.; and Passik, S.D., 2008. Challenges in using opioids to treat pain in persons with substance use disorders. Addiction Science & Clinical Practice 4(2):4-25.

The Search for Medications to Treat Stimulant Dependence
[PDF - 108K]
Kyle M. Kampman, M.D.

Alterman, A.I., et al., 1996. Prediction of attrition from day hospital treatment in lower socioeconomic cocaine-dependent men. Drug and Alcohol Dependence 40(3):227-233. Abstract Available

Baker, D.A., et al., 2003. Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nature Neuroscience 6(7):743-749. Abstract Available

Brodie, J.D., et al., 2005. Safety and efficacy of gamma-vinyl GABA (GVG) for the treatment of methamphetamine and/or cocaine addiction. Synapse 55(2):122-125. Abstract Available

Brodie, J.D.; Figuero, E.; and Dewey, S.L., 2003. Treating cocaine addiction: From preclinical to clinical trial experience with gamma-vinyl GABA. Synapse 50(3):261-265. Full Text Available

Carroll, K.M., et al., 1998. Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram. Addiction 93(5):713-727. Abstract Available

Carroll, K.M., et al., 2004. Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: A randomized placebo-controlled trial. Archives of General Psychiatry 61(3):264-272. Full Text Available

Cornish, J.L., and Kalivas, P.W., 2000. Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. Journal of Neuroscience 20(RC89):1-5. Full Text Available

Dackis, C.A., 2007. Modafinil for cocaine dependence. Paper presented at the American Society of Addiction Medicine, Medical-Scientific Conference, Miami, FL.

Dackis, C.A., et al., 2003. Modafinil and cocaine: A double-blind, placebo-controlled drug interaction study. Drug and Alcohol Dependence 70(1):29-37. Abstract Available

Dackis, C.A, et al., 2005. A double-blind, placebo-controlled trial of modafinil for cocaine dependence. Neuropsychopharmacology 30(1):205-211. Full Text Available

Dackis, C.A., and O'Brien, C., 2003. Glutamatergic agents for cocaine dependence. Annals of the New York Academy of Sciences 1003:328-345. Abstract Available

Dewey, S.L., et al., 1997. GABAergic attenuation of cocaine-induced dopamine release and locomotor activity. Synapse 25(4):393-398. Abstract Available

Elkashef, A.M., et al., 2008. Bupropion for the treatment of methamphetamine dependence. Neuropsychopharmacology, 33(5):1162-1170.

Fechtner, R.D., et al., 2006. Short-term treatment of cocaine and/or methamphetamine abuse with vigabatrin: Ocular safety pilot results. Archives of Ophthalmology 124(9):1257-1262. Full Text Available

George, T.P., et al., 2000. Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: A preliminary trial. Biological Psychiatry 47(12):1080-1086. Abstract Available

Gerasimov, M.R., et al., 1999. Gamma-vinyl GABA inhibits methamphetamine, heroin, or ethanol-induced increases in nucleus accumbens dopamine. Synapse 34(1):11-19. Abstract Available

Gibbs, J.W., et al., 2000. Cellular actions of topiramate: Blockade of kainate-evoked inward currents in cultured hippocampal neurons. Epilepsia 41(Suppl. 1):S10-S16. Abstract Available

Gonzalez, G., et al., 2003. Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: Results of a randomized pilot study. Addiction 98(11):1625-1632. Abstract Available

Hart, C.L., et al., 2008. Smoked cocaine self-administration is decreased by modafinil. Neuropsychopharmacology 33(4):761-768. Abstract Available

Higgins, S.T., et al., 1994. Incentives improve outcome in outpatient behavioral treatment of cocaine dependence. Archives of General Psychiatry 51(7):568-576. Abstract Available

Kampman, K.M., et al., 1999. Open trials as a method of prioritizing medications for inclusion in controlled trials for cocaine dependence. Addictive Behaviors 24(2):287-291. Abstract Available

Kampman, K.M., et al., 2001. Cocaine withdrawal symptoms and initial urine toxicology results predict treatment attrition in outpatient cocaine dependence treatment. Psychology of Addictive Behaviors 15(1):52-59. Abstract Available

Kampman, K.M., et al., 2004. A pilot trial of topiramate for the treatment of cocaine dependence. Drug and Alcohol Dependence 75(3):233-240. Abstract Available

Kampman, K.M., et al., 2006. A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms. Drug and Alcohol Dependence 85(2):129-137. Abstract Available

Kantak, K.M., et al., 2000. Evaluation of anti-cocaine antibodies and a cocaine vaccine in a rat self-administration model. Psychopharmacology (Berlin) 148(3):251-262. Abstract Available

Kosten, T., et al., 2002. Human therapeutic cocaine vaccine: Safety and immunogenicity. Vaccine 20(7-8):1196-1204. Abstract Available

Kosten, T., et al., 2003. Desipramine and contingency management for cocaine and opiate dependence in buprenorphine-maintained patients. Drug and Alcohol Dependence 70(3):315- 325. Abstract Available

Kushner, S.A.; Dewey, S.L.; and Kornetsky, C., 1999. The irreversible gamma-aminobutyric acid (GABA) transaminase inhibitor gamma-vinyl-GABA blocks cocaine self-administration in rats. Journal of Pharmacology and Experimental Therapeutics 290(2):797-802. Full Text Available

Kuzniecky, R., et al., 1998. Topiramate increases cerebral GABA in healthy humans. Neurology 51(2):627-629. Abstract Available

Malcolm, R., et al., 2006. Modafinil and cocaine interactions. American Journal of Drug and Alcohol Abuse 32(4):577-587. Abstract Available

Martell, B.A., et al., 2005. Vaccine pharmacotherapy for the treatment of cocaine dependence. Biological Psychiatry 58(2):158-164. Abstract Available

McCance-Katz, E.; Kosten, T.R.; and Jatlow, P., 1998. Disulfiram effects on acute cocaine administration. Drug and Alcohol Dependence 52(1):27-39. Abstract Available

McDougle, C.J., et al., 1994. Noradrenergic dysregulation during discontinuation of cocaine use in addicts. Archives of General Psychiatry 51(9):713-719. Abstract Available

Moeller, F.G., et al., 2007. Citalopram combined with behavioral treatment reduces cocaine use: A double-blind, placebo-controlled trial. American Journal on Drug and Alcohol Abuse 33(3):367-378. Abstract Available

Petrakis, I.L., et al., 2000. Disulfiram treatment for cocaine dependence in methadone-maintained opioid addicts. Addiction 95(2):219-228. Abstract Available

Poling, J., et al., 2006. Six-month trial of bupropion with contingency management for cocaine dependence in a methadone-maintained population. Archives of General Psychiatry 63(2):219-228. Full Text Available

Schmitz, B., et al., 2002. Visual field constriction in epilepsy patients treated with vigabatrin and other antiepileptic drugs: A prospective study. Journal of Neurology 249(4):469-475. Abstract Available

Sofuoglu, M., et al., 2000. Carvedilol affects the physiological and behavioral response to smoked cocaine in humans. Drug and Alcohol Dependence 60(1):69-76. Abstract Available

Sofuoglu, M., et al., 2003. Association of cocaine withdrawal symptoms with more severe dependence and enhanced subjective response to cocaine. Drug and Alcohol Dependence 69(3):273-282. Abstract Available

Substance Abuse and Mental Health Services Administration, Office of Applied Studies, 2006. Treatment Episode Data Set (TEDS): 1994-2004. National Admissions to Substance Abuse Treatment Services, DASIS Series: S-33, DHHS Publication No. (SMA) 06-4180, Rockville, MD: Substance Abuse and Mental Health Services Administration.

RESPONSE: ANTICIPATING NEW MEDICATIONS
[PDF - 100K]

Anton, R.F., et al., 2008. An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: Results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Archives of General Psychiatry 65(2):135-144.

Kampman, K.M., 2008. The search for medications to treat stimulant dependence. Addiction Science & Clinical Practice 4(2):28-35.

Dialectical Behavior Therapy for Substance Abusers
[PDF - 232K]
Linda A. Dimeff and Marsha M. Linehan

Alcoholics Anonymous, 2006. "Twelve Steps" (electronic version), http://www.alcoholics-anonymous.org/en_information_aa.cfm?PageID=17&SubPage=68. See also A.A. Fact File: http://www.alcoholics-anonymous.org/en_pdfs/m-24_aafactfile.pdf.

American Psychiatric Association, 1998. Gold Award: Integrating dialectical behavior therapy into a community mental health program. Psychiatric Services 49(10):1338-1340. Full Text Available

Beautrais, A.L.; Joyce, P.R.; and Mulder, R.T., 1999. Cannabis abuse and serious suicide attempts. Addiction 94(8):1155-1164. Abstract Available

Cacciola, J.S., et al., 1995. Treatment response of antisocial substance abusers. Journal of Nervous and Mental Disease 183(3):166-171. Abstract Available

Cacciola, J.S., et al., 2001. The relationship of psychiatric comorbidity to treatment outcomes in methadone maintained patients. Drug and Alcohol Dependence 61(3):271-280. Abstract Available

Darke, S., et al., 2004. Borderline personality disorder, antisocial personality disorder and risk-taking among heroin users: Findings from the Australian Treatment Outcome Study (ATOS). Drug and Alcohol Dependence 74(1):77-83. Abstract Available

Dulit, R.A., et al., 1990. Substance use in borderline personality disorder. American Journal of Psychiatry 147(8):1002-1007. Abstract Available

Frances, A.; Fyer, M.R.; and Clarkin, J.F., 1986. Personality and suicide. In: J.J. Mann and M. Stanley (Eds.), Psychobiology of Suicidal Behavior (Vol. 487). New York: Annals of the New York Academy of Sciences, pp. 281-293.

Koons, C.R., et al., 2001. Efficacy of dialectical behavior therapy in women veterans with borderline personality disorder. Behavior Therapy 32(2):371-390. Abstract Available

Kosten, T.A.; Kosten, T.R.; and Rounsaville, B.J., 1989. Personality disorders in opiate addicts show prognostic specificity. Journal of Substance Abuse and Treatment 6(3):163-168. Abstract Available

Linehan, M.M., 1987. Dialectical behavior therapy: A cognitive behavioral approach to parasuicide. Journal of Personality Disorders 1:328-333.

Linehan, M.M., 1993a. Cognitive-Behavioral Treatment of Borderline Personality Disorder. New York: Guilford Press.

Linehan, M.M., 1993b. Skills Training Manual for Treating Borderline Personality Disorder. New York: Guilford Press.

Linehan, M.M., in press. Skills Training Manual for Disordered Emotion Regulation. New York: Guilford Press.

Linehan, M.M., et al., 1991. Cognitive-behavioral treatment of chronically parasuicidal borderline patients. Archives of General Psychiatry 48(12):1060-1064. Abstract Available

Linehan, M.M., et al., 1999. Dialectical behavior therapy for patients with borderline personality disorder and drug-dependence. American Journal on Addictions 8(4):279-292. Abstract Available

Linehan, M.M., et al., 2002. Dialectical behavior therapy versus comprehensive validation therapy plus 12-step for the treatment of opioid dependent women meeting criteria for borderline personality disorder. Drug and Alcohol Dependence 67(1):13-26. Abstract Available

Linehan, M.M., et al., 2006. Two-year randomized controlled trial and follow-up of dialectical behavior therapy vs therapy by experts for suicidal behaviors and borderline personality disorder. Archives of General Psychiatry 63(7):757-766. Full Text Available

Linehan, M.M.; Dimeff, L.A.; and Sayrs, J.H.R., in press. Dialectical Behavior Therapy for Substance Use Disorder. New York: Guilford Press.

Linehan, M.M., and Heard, H.L., 1999. Borderline personality disorder: Costs, course, and treatment outcomes. In: N. Miller and K. Magruder (Eds.), The Cost Effectiveness of Psychotherapy: A Guide for Practitioners. New York: Oxford University Press, pp. 291-305.

Linehan, M.M.; Heard, H.L.; and Armstrong, H.E., 1993. Naturalistic follow-up of a behavioral treatment for chronically parasuicidal borderline patients. Archives of General Psychiatry 50(12):971-974. Abstract Available

Links, P.S., et al., 1995. Borderline personality disorder and substance abuse: Consequences of comorbidity. Canadian Journal of Psychiatry 40(1):9-14. Abstract Available

Lynch, T.R., et al., 2003. Dialectical behavior therapy for depressed older adults: A randomized pilot study. American Journal of Geriatric Psychiatry 11(1):33-45. Full Text Available

Marlatt, G.A., and Donovan, D.M., 2005. Relapse Prevention: Maintenance Strategies in the Treatment of Relapse Prevention. New York: Guilford Press.

McKay, J.R., et al., 2000. Prognostic significance of antisocial personality disorder in cocaine-dependent patients entering continuing care. Journal of Nervous and Mental Disease 188(5):287-296. Abstract Available

Nace, E.P.; Davis, C.W.; and Gaspari, J.P., 1991. Axis II comorbidity in substance abusers. American Journal of Psychiatry 148(1):118-120. Abstract Available

Rossow, I., and Lauritzen, G., 1999. Balancing on the edge of death: Suicide attempts and life-threatening overdoses among drug addicts. Addiction 94(2):209-219. Abstract Available

Rutherford, M.J.; Cacciola, J.S.; and Alterman, A.I., 1994. Relationships of personality disorders with problem severity in methadone patients. Drug and Alcohol Dependence 35(1):69-76. Abstract Available

Safer, D.L.; Telch, C.F.; and Agras, W.S., 2001. Dialectical behavior therapy for bulimia nervosa. American Journal of Psychiatry 158(4):632-634. Abstract Available

Stone, M.H.; Hurt, S.W.; and Stone, D.K., 1987. The PI 500: Long-term follow-up of borderline inpatients meeting DSM-III criteria. I: Global Outcome. Journal of Personality Disorders 1:291-298.

Telch, C.F.; Agras, W.S.; and Linehan, M.M., 2001. Dialectical behavior therapy for binge eating disorder. Journal of Consulting and Clinical Psychology 69(6):1061-1065. Abstract Available

Trull, T.J., et al., 2000. Borderline personality disorder and substance use disorders: A review and integration. Clinical Psychology Review 20(2):235-253. Abstract Available

van den Bosch, L.M., et al, 2005. Sustained efficacy of dialectical behaviour therapy for borderline personality disorder. Behaviour Research and Therapy 43(9):1231-1241. Abstract Available

Verheul, R., et al., 2003. Dialectical behaviour therapy for women with borderline personality disorder: 12-month, randomised clinical trial in The Netherlands. British Journal of Psychiatry 182:135-140. Full Text Available

Zanarini, M.C., et al., 2004. Axis I comorbidity in patients with borderline personality disorder: 6-year follow-up and prediction of time to remission. American Journal of Psychiatry 161(11):2108-2114. Full Text Available

RESPONSE: INNOVATIONS AND IMPLEMENTATION
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Budney, A.J., and Higgins, S.T., 1998. A Community Reinforcement Plus Vouchers Approach: Treating Cocaine Addiction. NIDA Therapy Manuals for Drug Addiction, Manual 2. NIH Publication No. 98-4309. Rockville, MD: National Institute on Drug Abuse.

Dimeff, L.A., and Linehan, M.M., 2008. Dialectical behavior therapy for substance abusers. Addiction Science & Clinical Practice 4(2):39-47. Addiction Science & Clinical Practice 4(2):28-35.