Summaries & Associations of Study Results
TR-248 4,4'-Methylenedianiline dihydrochloride
Target Organs and Levels of Evidence
NTP Technical Report Number 248
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| 4,4'-METHYLENEDIANILINE DIHYDROCHLORIDE 13552-44-8 |
06/16/82 | INTERMEDIATE FOR ISOCYANATES AND POLYISOCYANATES | Dosed-Water 0,150,300 PPM/50 PER GROUP | T.S.I. Mason Laboratories, Inc. |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: POSITIVE | THYROID GLAND FOLLICULAR CELL: CARCINOMA 0/49 0/47 7/48 | |||
| LIVER: NEOPLASTIC NODULE 1/50 12/50 25/50 | ||||
| FR: POSITIVE | THYROID GLAND C-CELL: ADENOMA 0/47 3/47 6/48 | |||
| THYROID GLAND FOLLICULAR CELL: ADENOMA 0/47 2/47 17/48 | ||||
| MM: POSITIVE | THYROID GLAND FOLLICULAR CELL: ADENOMA 0/47 3/49 16/49 | |||
| LIVER: CARCINOMA 10/49 33/50 29/50 | ||||
| ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 2/48 12/49 14/49 | ||||
| FM: POSITIVE | THYROID GLAND FOLLICULAR CELL: ADENOMA 0/50 1/47 13/50 | |||
| LIVER: ADENOMA 3/50 9/50 12/50 | ||||
| HEMATOPOIETIC SYSTEM: LYMPHOMA 13/50 28/50 29/50 | ||||
Web page last updated on February 10, 2006
