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High-End Instrumentation Grants - June 12, 2007ON THIS PAGE:
SEE ALSO: NCRR's High-End Instrumentation (HEI) grant program supports the purchase of research equipment that costs more than $750,000. Instruments in this price range include structural and functional imaging systems, macromolecular NMR spectrometers, high-resolution mass spectrometers, electron microscopes, and supercomputers. Brigham and Women's HospitalBoston, MA
Award: $2,000,000 An intra-operative 3-Tesla magnetic resonance imaging scanner will enable multi-modality navigation techniques for image-guidance during open surgeries, minimally invasive percutaneous therapies, vascular interventions, and thermal ablation of tumors.
Burnham Institute for Medical ResearchLa Jolla, CA Award: $1,444,784 Nuclear magnetic resonance spectroscopy instrumentation, which plays an important role in the study and characterization of interactions between small organic molecules and macromolecular targets, will be particularly useful in lead identification and optimization processes.
Johns Hopkins UniversityBaltimore, MD Award: $928,365 A hybrid linear ion trap-Fourier transform mass spectrometer—equipped with an electrospray ionization source, infrared multiphoton dissociation, and electron capture dissociation—will benefit researchers investigating ischemia and hypoxia, networks and pathways of lysine modifications, and the structural analysis of carbohydrates.
Nathan S. Kline Institute for Psychiatric ResearchOrangeburg, NY Award: $2,000,000 A 3-Tesla magnetic resonance imaging system with parallel imaging technology and spectroscopic imaging capabilities will facilitate investigations into micro-structural and gross structural deficits in the brain, as well as the functional consequences of schizophrenia, Alzheimer's disease, dementia, substance abuse, and child psychiatric disorders.
University of ArizonaTucson, AZ Award: $924,995 A hybrid quadrupole (or linear ion trap) Fourier transform ion cyclotron resonance mass spectrometer with high-throughput, high-resolution, and high-mass accuracy and equipped with electron capture dissociation and infrared multiphoton dissociation will help investigators solve problems that require detailed structural studies of proteins and protein complexes, post-translational protein modifications such as phosphorylation, Valley Fever vaccine candidates, polyamines important in colorectal cancer, and organic tholins of the type produced on Titan, a moon of Saturn.
University of California, San DiegoLa Jolla, CA Award: $2,000,000 A high-performance, intermediate voltage transmission electron microscope will replace an outdated instrument at the NCRR-funded National Microscopy and Imaging Research Resource, enabling 3-D imaging of sections of cells and biological tissues.
University of Colorado at Denver and Health Sciences CenterDenver, CO Award: $1,067,480 A high-performance linear ion trap-Fourier transform ion cyclotron resonance mass spectrometer—providing enhanced sensitivity, electron capture dissociation, and "top down" mass measurements of intact proteins—will be housed in the cancer center and mass spectrometry/proteomics facility to ensure optimal performance and research productivity.
University of Connecticut School of Medicine and DentistryFarmington, CT Award: $2,000,000 An 800 megahertz nuclear magnetic resonance spectrometer will facilitate field-dependent studies of relaxation used to probe molecular dynamics, supporting investigations of proteins that participate in repair at the sites of DNA damage, proteins that function as tumor suppressors and their mutants, and enzymes involved in antibiotic resistance, among others.
University of Maryland Biotechnology InstituteBaltimore, MD Award: $737,850 A high-speed system for confocal fluorescence imaging, subcellular photolysis, and patch clamp control of single cells will allow scientists to continue studies of calcium signaling at high temporal and spatial resolution in living cells, as well as investigations involving neuronal and brain slice imaging.
University of Texas Health Science CenterSan Antonio, TX Award: $1,950,000 A small-bore, 9.4-Tesla magnetic resonance imaging scanner will make possible non-invasive studies of a wide variety of animal species from transgenic mice to non-human primates, spanning multiple disciplines including oncology, orthopedics, cardiology, organ transplantation, brain development and aging, and will be used to model treatments for cancer, heart disease, osteoarthritis, neurological and psychiatric disorders.
University of WashingtonSeattle, WA Award: $1,040,735 A pulsed electron paramagnetic resonance/X-band electron nuclear double resonance spectrometer will be used to study the function of enzymes, structural proteins and proteins at DNA and RNA interfaces.
University of Wisconsin School of Medicine and Public HealthMadison, WI Award: $1,499,745 A cyclotron and related devices for positron emission tomography tracer development and production will enable molecular level physiological functional imaging to facilitate research involving cancer, neuroscience, cardiovascular, and regenerative medicine.
Vanderbilt UniversityNashville, TN Award: $2,000,000 A 7-Tesla human magnetic resonance imaging and spectroscopy system will facilitate research in a number of areas including: the development of advanced imaging and spectroscopic methods; studies of brain structure and function in humans as well as non-human primates; investigations of biochemistry and metabolism in vivo; and studies of cancer and the response of tumors to novel treatments.
Yale UniversityNew Haven, CT Award: $1,054,868 New, cutting-edge DNA sequencing/genotyping technologies, which can sequence DNA more quickly and economically than current instruments and will facilitate genome research on several important diseases including epilepsy, psychiatric disorders, autism, cardiovascular disorders, and cancer. Contact InformationDr. Marjorie A. Tingle |
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