| Topic: | Kidney and Urologic Diseases (KU) |
| Title: | Spectrum of Renal Diseases Associated with Extreme Forms of Insulin Resistance. |
| Author: | Musso, C., et al. |
| Source: | Clinical Journal of the American Society of Nephrology. 1(4): 616-622. July 2006. |
| Abstract: | This review article considers the spectrum of renal diseases associated with extreme forms of insulin resistance. In patients with syndromes of extreme insulin resistance, the proteinuric forms of renal disease are common, but the authors note that the renal pathology usually is not diabetic nephropathy. For example, in the lipodystrophy syndromes, membranoproliferative glomerulonephritis type 1 and type 2, focal segmental glomerulosclerosis, and also diabetic nephropathy are seen. In the syndromes of autoantibodies to the insulin receptor, the various forms of lupus glomerulonephritis are seen. Even in patients with type 2 diabetes, the renal pathology may not be diabetic nephropathy. The authors conclude that this means that renal biopsy has an important role in defining the pathology that leads to proteinuric nephropathy; this leads to a more successful therapeutic approach. 4 figures. 4 tables. 40 references. |
| Format: | Journal Article |
| Language: | English. |
| Major Keywords: | Kidney Diseases. Pathology. Insulin Resistance. Pathogenesis. Proteinuria. Diagnosis. |
| Minor Keywords: | Diabetic Nephropathy. Type 2 Diabetes. Glomerulosclerosis. Immune System. Diagnostic Tests. Biopsy. |
| Publication Number: | KUJA11508. |
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