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| Topic: |
Kidney and Urologic Diseases (KU) |
| Title: |
Recurrent Lupus Nephritis in Renal Transplant Recipients Revisited: It Is Not Rare. |
| Author: |
Goral, S., et al. |
| Source: |
Transplantation. 75(5): 651-656. March 2003. |
| Abstract: |
Although recurrent lupus nephritis (RLN) after kidney transplantation is reported to be rare (1 to 4 percent), recent studies suggest a higher incidence. This article reports on a study undertaken to determine the incidence of RLN in a large cohort of renal transplant recipients with systemic lupus erythematosus (SLE). The authors reviewed the records of 54 renal (kidney) transplant recipients with SLE. Thirty-one patients underwent biopsy because of worsening renal function and proteinuria (protein in the urine). Among the 50 patients with at least 3 months of followup, RLN was present in 15 (52 percent of patients who underwent biopsy, 30 percent of total patients). One patient had graft loss because of RLN at 10.5 years. The duration of dialysis before transplantation was not different between patients with RLN compared to patients without RLN. Overall patient survival was 96 percent at 1 year and 82 percent at 5 years. The authors conclude that RLN is more common than previously reported, but in this series, graft loss because of RLN was rare. Aggressive use of allograft biopsies and morphologic evaluation are important factors in the diagnosis of RLN. 2 figures. 2 tables. 29 references. |
| Format: |
Journal Article |
| Language: |
English. |
| Major Keywords: |
Kidney Diseases. Transplantation. Systemic Lupus Erythematosus. Nephritis. Morbidity. Mortality. Recurrence. |
| Minor Keywords: |
Risk Factors. Biopsy. Diagnosis. Symptoms. Kidney Glomerulus. Patient Care Management. |
| Publication Number: |
KUJA10910 |
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