National Cancer Institute Center for Bioinformatics (NCICB) projects build on our core infrastructure, tools, and services to fulfill the needs of specific research communities. Within each project, participants collaborate in developing and/or adopting informatics components that provide innovative ways to integrate data and share new findings. These components can be used by others working in the given research area, and many have broader utility to researchers outside the cancer community. Specific tools may be found in the Tools and Downloads sections of this Web site.

caAdapter    caAdapter is an open source tool set that provides model mapping services in support of caCORE components and facilitates data mapping and transformation among different kinds of data sources including HL7 v2 messages, HL7 v3 messages, and Regulatory Data Sets. caAdapter has a component-based architecture to support message development and reporting using standard data formats. It also integrates with other clinical trials applications such as caXchange. caAdapter provides web service access and APIs for easy application integration. caBIG™    The cancer Biomedical Informatics Grid? or caBIG? is a voluntary network or grid connecting individuals and institutions to enable the sharing of data and tools, creating a World Wide Web of cancer research. Activities cover clinical trials management systems, tissue banks and pathology tools, integrated cancer research, architecture, vocabularies and common data elements, data sharing and intellectual capital. The infrastructure and tools created by caBIG?also have broad utility outside the cancer community. Currently, 50 NCI-designated cancer centers and 30 other organizations—over 600 individuals in all—are engaged in caBIG? under the leadership of the National Cancer Institute's Center for Bioinformatics. Cancer Gene Data Curation Project   The Cancer Gene Data Curation Project is an attempt to create a database of associations between genes and diseases and genes and drug compounds derived from the biomedical literature. The project involves a mixture of automatic text mining, semi-automatic verification, and manual validation/scoring of results. A pilot study involving 1000 genese was completed in March 2005 by the NCICB, ScenPro, and Biomax Solutions, Inc. The next phase of this study began on 20-Sep-2005, and will involve the curation of 1500 additional genes by early 2006. National Cancer Imaging Archive (NCIA)    The in vivo image repository provides the cancer research community, industry, and academia with access to image archives that can be used for many purposes including the potential to assist in the development and validation of analytical software tools supporting: lesion detection and classification software, accelerated diagnostic imaging decision, and quantitative imaging assessment of drug response. The repository provides access to imaging resources that will improve the use of imaging in today's cancer research and practice by: increasing the efficiency and reproducibility of imaging cancer detection and diagnosis, leveraging imaging to provide an objective assessment of therapeutic response, and ultimately enabling the development of imaging resources that will lead to improved clinical decision support. I-SPY    The I-SPY project is a national study that uses imaging and molecular analysis to predict treatment response to breast cancer therapy. The I-SPY team is collecting, analyzing, and sharing diverse genomic and clinical data across organizations. The goal of this project is to identify and integrate treatment response biomarkers for analysis in support of translational research. Mouse Models    The NCI Mouse Models of Human Cancers Consortium (MMHCC) is a collaborative program to derive, characterize, and validate mouse models of human cancers and to make these models available to researchers who engage in basic, translational, clinical, or epidemiological investigations using mice. REMBRANDT    The purpose of the REpository of Molecular BRAin Neoplasia DaTa (REMBRANDT) project is to provide an open and accessible portal for a national molecular, genetic, and clinical database of several thousand primary brain tumors (including gliomas). REMBRANDT is a bioinformatics knowledgebase that uses data warehousing technology to host and integrate molecular research and clinical trials data related to brain cancers. This comprehensive information repository provides researchers the ability to perform ad hoc querying and reporting across multiple data domains, including gene expression, chromosomal aberrations, and clinical data. SpiderWeb    SpiderWeb is a network for sharing clinical and molecular information across enterprises. It provides a standard method for linking multiple databases by using common vocabulary, standards, technology, and infrastructure—while at the same time maintaining the security and confidentiality of patient information. SpiderWeb gives researchers the ability to compare genomic and clinical information across trials in order to diagnose genetic predisposition, sub-classify diseases, select optimal therapies, and design better diagnostics and therapeutics.