Sponsored by
The National Institute of Child Health and Human Development
The National Institute of Diabetes and Digestive and Kidney Diseases
The Office of Rare Diseases
The Office of Research on Women's Health
National Institutes of Health
Department of Health and Human Services


Hyatt Regency Bethesda
One Bethesda Metro
Bethesda, Maryland 20814

November 10-11, 2005

Organizers

Jon Levine
Department of Neurobiology and Physiology
Northwestern University

Emilie Rissman
Department of Biochemistry and Molecular Genetics
University of Virginia

Louis DePaolo
Reproductive Sciences Branch
Center for Population Research
NICHD, NIH, DHHS

AGENDA

Thursday, November 10th

	8:00 am	OPENING REMARKS Louis DePaolo, Reproductive Sciences Branch, CPR, NICHD Giovanna Spinella, Office of Rare Diseases, OD, NIH, DHHS
	8:10	KEYNOTE ADDRESS GnRH Research Through the Looking Glass Margaret Wierman, University of Colorado Health Science Center
Session I.		DEVELOPMENT OF GNRH NEURONS Chair: Ei Terasawa, University of Wisconsin
	9:00	Linking Function, Origin, and Genetic Pathways in the Development of Gonadotropin-Releasing Hormone Cells Kathleen Whitlock, Cornell University
	9:30	Migration and Maturation of GnRH-1 Neurons Susan Wray, NINDS, NIH, DHHS
	10:00	Break
	10:15	GnRH Neuron Migration: A Long and Winding Road Stuart Tobet, Colorado State University
	10:45	FGF Signaling Regulates GnRH Neuron Genesis, Migration and Axon Targeting Pei-San Tsai, University of Colorado at Boulder
Session II.		PUBERTY Chair: Tony Plant, University of Pittsburgh
	11:15	The Discovery of New Genes Involved in the Neuroendocrine Control of Puberty Sergio Ojeda, Oregon Health & Science University
	11:45	Anatomical and Functional Characteristics of the GnRH Neuronal System: Relationship to Puberty Cheryl Sisk, Michigan State University
	12:15 pm	Integration of Afferent Signals to GnRH Neurons by Two Distinct Populations of Kisspeptin Neurons in the Forebrain Robert Steiner, University of Washington
	12:45	Lunch
Session III.		CELLULAR BASIS OF PULSATILITY Chair: Richard Weiner, University of California at San Francisco
	2:00	Regulation of GnRH Secretion Kevin Catt, NICHD, NIH, DHHS
	2:30	The Clockworks in Reproduction: The Role of the Circadian Clock in GnRH Secretion Pat Chappell, University of California, San Diego
	3:15	Intrinsic Properties of GnRH Neurons that may Contribute to Pulse Generation Suzanne Moenter, University of Virginia
	3:45	Break
Session IV.		STEROID ACTIONS Chair: Judith Turgeon, University of California at Davis
	4:00	Unravelling Estrogen Feedback to GnRH Neurons with Transgenics Alan Herbison, University of Otago, New Zealand
	4:30	Expression of Ion Channels in GnRH Neurons; Role in Burst Firing Oline Ronnekleiv, Oregon Health & Science University
	5:00	Progesterone Receptors Mediating Negative Feedback: New and Fast, or Old or Slow? Jon Levine, Northwestern University
	5:30	Adjourn

Friday, November 11th

Session V.		Metabolic and Stress Regulation Chair: Sally Radovick, Johns Hopkins Medical Institutes
	8:00 am	Interaction Between Energy Balance and the Regulation of GnRH Neurons: Lactation as a Model M. Susan Smith, Oregon Health & Science University
	8:30	Role and Actions of Cortisol in Mediating Stress-Induced Reproductive Suppression Fred Karsch, University of Michigan
	9:00	Regulation of GnRH by Stress and Energy Availability in Humans Anne Loucks, Ohio University
	9:30	Break
Session VI.		Environment and Behavior Chair: Emilie Rissman, University of Virginia
	9:45	GnRH Influence on Reproductive Behavior and Central Chemosensory Processing in Male Golden Hamster Michael Meredith, Florida State University
	10:15	The Role of Mammalian GnRH-II in the Coordination of Energy Balance and Reproduction Alexander Kauffman, University of Virginia
	10:45	From Genes to Behavior and from Birds to Humans: Conserved Properties of GnIH George Bentley, University of California at Berkeley
	11:15	Break
Session VII.		GNRH RECEPTORS AND SIGNALING Chair: Ursula Kaiser, Brigham & Women's Hospital
	11:30	Cell Signaling and the GnRH Receptor: Membrane Compartments, Signaling Complexes and Target Genes Marc Roberson, Cornell University
	12:00 pm	Systems Biology and the Single Gonadotrope Stuart Sealfon, Mount Sinai School of Medicine
	12:30	Regulation of Trafficking of the GnRH Receptor P. Michael Conn, Oregon Health & Science University
	1:00	Lunch
Session VIII.		PHYLOGENY Chair: Gloria Hoffman, University of Maryland
	2:00	Ligand-Induced Selective-Signaling (LiSS) at the GnRH Receptor Robert Millar, MRC Human Reproductive Science, Edinburgh
	2:30	New Insights into the GnRH Neuronal System of Primates Henrik Urbanski, Oregon Health & Science University
Session IX.		CLINICAL APPLICATIONS Chair: Janet Hall, Massachusetts General Hospital
	3:00	Multi-faceted role of GnRH-I and GnRH-II in Reproduction Peter Leung, University of Vancouver, British Columbia
	3:30	Upstream Determinants of GnRH Secretion : Evidence from Human Investigation William Crowley, Massachusetts General Hospital
	4:00	Testosterone, GnRH Frequency and the Evolution of PCOS John Marshall, University of Virginia
	4:30	Adjourn