Inclusion Criteria:

• Postmenopausal female, in good health (at least 5 years since last menses)
• Age ≥45 and ≤70
• Weight + or - 20% of the Metropolitan Life weight table
• Plasma CTx-1 ≥ 0.25 ng/mL
• Total Ca++, P, and Mg++ within normal range
• Willing and able to comply with all study requirements
• Willing and able to sign written informed consent
• Negative urine pregnancy test at screening
• Negative Screen for Hepatitis B and C, HIV and drugs of abuse

Exclusion Criteria:

• History of parathyroid, thyroid, pituitary or adrenal diseases
• History of musculoskeletal disease
• History of gastro-esophageal reflux disease (GERD) or other significant gastrointestinal disorders
• History of cancer within 5 years of enrollment other than basal cell carcinoma
• History of regular use of NSAID
• History of surgery within 60 days of enrollment
• History of hypersensitivity or allergies (other than seasonal allergies) within 5 years of enrollment including known sensitivity to the active ingredients or the excipients in the study medications
• Use of concomitant medications other than acetaminophen within 7 days of enrollment or anticipated need to use such concomitant medications during the study
• Use of bisphosphonates within 6 months, SERMS, estrogen or estrogen-like drugs 2 months, or calcitonin 1 month
• Presence of any clinically significant illness
• Unwilling or unable to comply with all study requirements
• Unwilling or unable to sign written, informed consent
• History of drug or alcohol abuse
• Participation in any clinical study of an investigational drug within 60 days of enrollment
• Plasma CTx-1 less than 0.25 ng/mL