CounterACT Website |
---|
|
CounterACT Publications
Neurotoxic Organophosphorus Poisons (e.g. anti-convulsants, anti-seizures, neuroprotectants, cholinesterase reactivators, nerve agent bioscavengers)
Aroniadou-Anderjaska V, Fritsch B, Qashu F, and Braga MF. (2008) Pathology and pathophysiology of the amygdala in epileptogenesis and epilepsy. Epilepsy Res. 78(2-3): 102-16. Abstract
Beck JM, Hadad CM. (2008) Hydrolysis of nerve agents by model nucleophiles: A computational study. Chem Biol Interact. 175(1-3): 200-3. Abstract
Boado RJ, Zhang Y, Zhang Y, Wang Y, Pardridge WM. (2008) IgG-Paraoxonase-1 fusion protein for targeted drug delivery across the human blood-brain barrier. Mol Pharm. [Epub ahead of print] Abstract
Carter DS, Harrison AJ, Falenski KW, Blair RE, DeLorenzo RJ. (2008) Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus. Epilepsy Res. 79(2-3): 213-23. Abstract
Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, Attkisson E, Delorenzo RJ. (2008) Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: Role of NMDA receptor activation and NMDA dependent calcium entry. Eur J Pharmacol. 583(1): 77-83. Abstract
Deshpande LS, Nagarkatti N, Sombati S, Delorenzo RJ. (2008) The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons. Epilepsy Res 79(2-3): 158-65. Abstract
Deshpande LS, Sun DA, Sombati S, Baranova A, Wilson MS, Attkisson E, Hamm RJ, Delorenzo RJ. (2008) Alterations in neuronal calcium levels are associated with cognitive deficits after traumatic brain injury. Neurosci Lett 441(1): 115-9. Abstract
Ding SJ, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F, Asojo O, Thompson CM, Hinrichs SH, Masson P, Lockridge O. (2008) Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin. Chem Res Toxicol. 21(9): 1787-94. Abstract
Geyer BC, Woods RR, Mor TS. (2008) Increased organophosphate scavenging in a butyrylcholinesterase mutant. Chem Biol Interact 175(1-3): 376-9. Abstract
Goodkin HP, Joshi S, Mtchedlishvili Z, Brar J, and Kapur J. (2008) Subunit-specific trafficking of GABAa receptors during status epilepticus. J Neurosci. 28(10): 2527-38. Abstract
Li H, Ricordel I, Tong L, Schopfer LM, Baud F, Megarbane B, Maury E, Masson P, Lockridge O. (2008) Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum. J Appl Toxicol. [Epub ahead of print] Abstract
Li H, Tong L, Schopfer LM, Masson P, Lockridge O. (2008) Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase. Chem Biol Interact 175(1-3): 68-72. Abstract
Lockridge O, Xue W, Gaydess A, Grigoryan H, Ding SJ, Schopfer LM, Hinrichs SH, Masson P. (2008) Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including residue 59 lysines. J Biol Chem 283(33): 22582-90. Abstract
Nagarkatti N, Deshpande LS, Delorenzo RJ. (2008) Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture. Neurosci Lett. 436(3): 289-93. Abstract
Radic Z, Manetsch R, Fournier D, Sharpless KB, Taylor P. (2008) Probing gorge dimensions of cholinesterases by freeze-frame click chemistry. Chem Biol Interact. 175(1-3): 161-5. Abstract
Reeves TE, Wales ME, Grimsley JK, Li P, Cerasoli DM, Wild JR. (2008) Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities. Protein Engineering, Design & Selection 21(6): 405-412. Abstract
Sun DA, Despande LS, Sombati S, Baranova A, Wilson MS, Hamm RJ, Delorenzo RJ. (2008) Traumatic brain injury causes a long-lasting calcium (Ca(2+))-plateau of elevated intracellular Ca levels and altered Ca(2+) homeostatic mechanisms in hippocamplal neurons surviving brain injury. Eur J Neurosci 27(7): 1659-72. Abstract
Talley TT, Harel M, Hibbs Re, Radic Z, Tomizawa M, Casida JE, Taylor P. (2008) Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore. Proc Natl Acad Sci USA 105(21): 7606-11. Abstract
Tomizawa M, Maltby D, Talley TT, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, Casida JE. (2008) Atypical nicotinic agonist bound conformations conferring subtype selectivity. Proc Natl Acad Sci USA 105(5): 1728-32. Abstract
Wang H, Cheng X, Taylor P, McCammon JA, Sine SM. (2008) Control of cation permeation through the nicotinic receptor channel. PLoS Comput. Biol. 4(2): e41. Abstract
Wetherington J, Serrano G, Dingledine R. (2008) Astrocytes in the epileptic brain. Neuron 58(2): 168-78. Abstract
Woods RR, Geyer BC, Mor TS. (2008) Hairy-root organ cultures for the production of human acetylcholinesterase. BMC Biotechnol. 8(1): 95. Abstract
Yeung DT, Smith JR, Sweeney, RE, Lenz DE, and Cerasoli DM. (2008). A gas chromatography-mass spectrometry approach to examine stereoselective interaction of human plasma proteins with soman. J. Anal. Toxicol. 32(1): 86-91. Abstract
Vesicating Agents (e.g. sulfur mustard)
Black AT, Gray JP, Shakarjian MP, Laskin DL, Heck DE, Laskin JD. (2008) Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to paraquat. Toxicol Appl Pharmacol 231(3): 384-92. Abstract
Black AT, Gray JP, Shakarjian MP, Mishin V, Laskin DL, Heck DE, Laskin JD. (2008) UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes. Toxicol Appl Pharmacol 232(1): 14-24. Abstract
Conlon P, Yang CJ, Wu Y, Chen Y, Martinez K, Kim Y, Stevens N, Marti AA, Jockusch S, Turro NJ, Tan W. (2008) Pyrene excimer signaling molecular beacons for probing nucleic acids. J Am Chem Soc 130(1): 336-42. Abstract
Day BJ. (2008) Antioxidants as potential therapeutics for lung fibrosis. Antioxid Redox Signal. 10(2): 355-70. Abstract
Gould N, White CW, Day BJ. (2008) A role for mitochondrial oxidative stress in sulfur mustard analog CEES-induced lung cell injury and antioxidant protection. J Pharmacol Exp Ther [Epub ahead of print] Abstract
Kim Y, Cao Z, Tan W. (2008) Molecular assembly for high-performance bivalent nucleic acid inhibitor. Proc Natl Acad Sci USA 105(15): 5664-9. Abstract
Mallikaratchy P, Tang Z, Tan W. (2008) Cell specific aptamer-photosensitizer conjugates as a molecular tool in photodynamic therapy. ChemMedChem 3(3): 425-8. Abstract
Price JA, Rogers JV, McDougal JN, Shaw MQ, Reid FM, Kiser RC, Graham JS. (2008) Gene expression analysis of bromine-induced burns in porcine skin. Toxicol Lett 182(1-3): 69-78. Abstract
O'Neill HC, Rancourt RC, White CW. (2008) Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH. Antioxidants & Redox Signaling 10(2): 277-85. Abstract
Shangguan D, Meng L, Cao ZC, Xiao Z, Fang X, Li Y, Cardonna D, Witek RP, Liu C, Tan W. (2008) Identification of liver cancer-specific aptamers using whole live cells. Anal Chem. 80(3): 721-8. Abstract
Svoboda KK, Fischman DA, Gordon MK. (2008) Embryonic chick corneal epithelium: A model system for exploring cell-matrix interactions. Dev Dyn. 237(10): 2667-75. Abstract
Tewari-Singh N, Rana S, Gu M, Pal A, Orlicky DJ, White CW, Agarwal R. (2008) Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide (CEES)-induced skin injury in SKH-1 hairless mice. Toxicol Sci. [Epub ahead of print] Abstract
Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD. (2008) Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med 44(6): 1169-79. Abstract
Xiao Z, Shangguan D, Cao Z, Fang X, Tan W. (2008) Cell-specific internalization study of an aptamer from whole cell selection. Chemistry 14(6): 1769-75. Abstract
Pulmonary Agents (e.g. chlorine, bromine, etc.)
Bessac BF, Jordt SE. (2008) Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda). 23:360-70. Abstract
Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE. (2008) TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest. 118(5): 1899-910. Abstract
Bessac BF, Sivula M, von Hehn CA, Caceres AI, Escalera J, Jordt SE. (2008) Transient receptor potential ankyrin 1 antagonist block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J. [Epub ahead of print] Abstract
Che MM, Conti M, Boylan M, Sciuto AM, Gordon RK, Nambiar MP. (2008) Blood and bronchoalveolar lavage fluid acetylcholinesterase levels following microinstillation inhalation exposure to sarin in guinea pigs. Inhal Toxiocl. 20(9): 821-8. Abstract
Chen L, Song W, Davis IC, Shrestha K, Schwiebert E, Sullender WM, Matalon S. (2008) Inhibition of Na+ transport in lung epithelial cells by respiratory syncytial virus infection. Am J Respir Cell Mol Biol. [Epub ahead of print] Abstract
Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. (2008) EGFR-tyrosine kinase inhibitors diminish transforming growth factor-alpha induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 294(6): L1217-25. Abstract
Janciauskiene S, Nita I, Subramaniyam D, Li Q, Lancaster JR, Matalon S. (2008) Alpha1-antitrypsin inhibits the activity of the matriptase catalytic domain in vitro. Am J Respir Cell Mol Biol. 39(6):631-7. Abstract
Ji HL, Song W, Gao Z, Su XF, Nie HG, Jiang Y, Peng JB, He YX, Liao Y, Zhou YJ, Tousson A, Matalon S. (2008) SARS-CoV proteins decrease levels and activity of human ENaC via activation of distinct PKC isoforms. Am J Physiol Lung Cell Mol Physiol. [Epub ahead of print] Abstract
Leustik M, Doran S, Bracher A, Williams S, Squadrito GL, Schoeb TR, Postlethwait EM, Matalon S. (2008) Mitigation of chlorine induced lung injury by low molecular weight antioxidants. Am J Physiol Lung Cell Mol Physiol. 295(5): L733-43. Abstract
Mongan M, Tan Z, Chen L, Peng Z, Dietsch M, Su B, Leikauf G, Xia Y. (2008) Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury. Toxicol Sci 104(2): 405-11. Abstract
Panayiotidis MI, Stabler SP, Allen RH, Papa A, White CW. (2008) Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells. Mutat Res [Epub ahead of print] Abstract
Tian X, Tao H, Brisolara J, Chen J, Rando RJ, Hoyle GW. (2008) Acute lung injury induced by chlorine inhalation in C57BL/6 and FVB/N mice. Inhal Toxicol. 20(9): 783-93. Abstract
Metabolic/Cellular Toxins (e.g. cyanide)
Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, Sharma VS, Pilz RB, Bigby TD, Boss GR. (2008) Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J. Infect. Dis. 197(3): 457-64. Abstract
Paralytic Neurotoxins (e.g. scorpion toxins)
Cohen L, Lipstein N, Karbat I, Ilan N, Gilles N, Kahn R, Gordon D, Gurevitz M. (2008) Miniaturization of scorpion beta-toxins uncovers a putative ancestral surface of interaction with voltage-gated Na-channels. J. Biol. Chem. 283(22): 15169-76. Abstract
Schnur E, Turkov M, Kahn R, Gordon D, Gurevitz M, Anglister J. (2008) NMR analysis of interaction of Lqh-alphaIT scorpion toxin with a peptide corresponding to the D4/S3-S4 loop of insect para voltage-gated sodium channel. Biochemistry 47(3): 911-21. Abstract
Sokolov S, Kraus RL, Scheuer T, Catterall WA. (2008) Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II. Mol Pharmacol. 73(3): 1020-8. Abstract
Diagnostics (e.g. EEG devices, OP detectors/biosensors)
Lee A, Liu G, Heng C, Tan S, Lim T, Lin Y . (2008) Sensitive electrochemical detection of horseradish peroxidase at disposable screen-printed carbon electrode. Electroanalysis 20(18): 2040-6. Abstract
Lin YY, Liu G, Wai CM, Lin Y. (2008) Bioelectrochemical immunoassay of polychlorinated biphenyl. Anal Chim Acta 612(1): 23-8. Abstract
Liu G, Wang J, Barry R, Petersen C, Timchalk C, Gassman PL, Lin Y. (2008) Nanoparticle-based electrochemical immunosensor for detection of phosphorylated acetylcholinesterase: An exposure biomarker of organophosphate pesticides and nerve agents. Chemistry - A European Journal 14(32): 9951-9. Abstract
Wang H, Wang J, Choi D, Tang Z, Wu H, Lin Y. (2008) EQCM immunoassay for phosphorylated acetylcholinesterase as a biomarker for organophosphate exposures based on selective zirconia adsorption and enzyme-catalytic precipitation. Biosens Bioelectron [Epub ahead of print] Abstract
Wang H, Wang J, Timchalk C, Lin Y. (2008) Magnetic electrochemical immunoassays with quantum dot labels for sensitive detection of phosphorylated acetylcholinesterase in plasma. Anal. Chem. 80(22): 8477-84. Abstract
Wang J, Lin Y. (2008) Functionalized carbon nanotubes and nanofibers for biosensing applications. Trends Anal.Chem. 27(7): 619-26. Abstract
Wang J, Liu G, Wu H, Lin Y. (2008) Quantum-dot-based electrochemical immunoassay for high-throughput screening of the prostate-specific antigen. Small 4(1): 82-6 Abstract
Wang J, Liu G, Timchalk C, Lin Y. (2008) Carbon nanotube-based electrochemical sensor for assay of salivary cholinesterase enzyme activity: an exposure biomarker of organophosphate pesticides and nerve agents. Environ. Sci. Technol. 42(7): 2688-2693. Abstract
Wu H, Huo Q, Varnum S, Wang J, Liu G, Nie Z, Liu J, Lin Y. (2008) Dye-doped silica nanoparticle labels/protein microarray for detection of protein biomarkers. Analyst 133: 1550-5. Abstract
Wu H, Wang J, Wang Z, Fisher DR, Lin Y. (2008) Apoferritin-templated yttrium phosphate nanoparticle conjugates for radioimmunotherapey of cancers. J Nanosci Nanotechnol. 8(5): 2316-22. Abstract
(63 Total 2008 Publications)
Last updated January 30, 2009