Fluorine-18-α-Methyltyrosine Positron Emission Tomography (18F-FMT PET) for Therapy Response in Lung Cancer

This study has been completed.

First Received: January 20, 2009 No Changes Posted

Sponsors and Collaborators:	Gunma University J-Pharma
Information provided by:	Gunma University
ClinicalTrials.gov Identifier:	NCT00826033

Purpose

L-[3-18F]-α-methyltyrosine (18F-FMT) is an amino-acid tracer for positron emission tomography (PET). The investigators evaluated the value of 18F-FMT PET for the assessment of therapy response in patients with lung cancer as compared with that of 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) PET.

The patients with lung cancer underwent PET studies with 18F-FDG and 18F-FMT before and after radio-/chemotherapy. The investigators used the ratio of the SUVmax of the mediastinal (N2) lymph node to the SUVmax of the primary tumor (N/P ratio ). All patients were divided into two groups of N/P ratio<1 and N/P ratio≥1, and the survival time was estimated by Kaplan-Meier method.

Condition
Non-Small Cell Lung Cancer

MedlinePlus related topics: Cancer Lung Cancer

Drug Information available for: Fluoride Sodium fluoride Stannous fluoride

U.S. FDA Resources

Study Type:	Observational
Study Design:	Prospective
Official Title:	Fluorine-18-α-Methyltyrosine Positron Emission Tomography to Measure Therapy

Further study details as provided by Gunma University:

Groups/Cohorts
Therapy monitoring

Eligibility

Ages Eligible for Study:	20 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

This study was conducted at the Gunma University Hospital.

Criteria

Inclusion Criteria:

primary lung cancer All patients received first-line chemotherapy

Exclusion Criteria:

Patients with diabetus mellitus

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00826033

Locations

Japan
Gunma University Graduate School of Medicine
Gunma, Japan, 371-8511

Sponsors and Collaborators

Gunma University

J-Pharma

More Information

No publications provided

Study ID Numbers:	Mol Imaing 1
Study First Received:	January 20, 2009
Last Updated:	January 20, 2009
ClinicalTrials.gov Identifier:	NCT00826033 History of Changes
Health Authority:	Japan: Ministry of Health, Labor and Welfare

Keywords provided by Gunma University:

Fluorine-18-α-methyltyrosine
Positron emission tomography
Lung cancer
chemotherapy
monitoring

Study placed in the following topic categories:

Thoracic Neoplasms
Respiratory Tract Diseases
Lung Neoplasms
Lung Diseases
Non-small Cell Lung Cancer

Fluorides
Carcinoma, Non-Small-Cell Lung
Neoplasms, Glandular and Epithelial
Carcinoma

Additional relevant MeSH terms:

Thoracic Neoplasms
Respiratory Tract Neoplasms
Neoplasms
Neoplasms by Site
Neoplasms by Histologic Type
Respiratory Tract Diseases

Lung Neoplasms
Lung Diseases
Carcinoma, Non-Small-Cell Lung
Neoplasms, Glandular and Epithelial
Carcinoma

ClinicalTrials.gov processed this record on May 06, 2009